Financial review for the three months to 30 September 1999 Lundbeck's turnover and earnings remained buoyant in the third quarter; turnover increased by 22% over the level in the third quarter of 1998 to DKK 1, 036 million. This increase is attributable to continued strong sales growth for Cipramil and CelexaTM. Third-quarter sales of Cipramil outside the USA increased to DKK 608 million, a 29% increase as compared with the same period last year. Sales of Cipramil improved in all of Lundbeck's markets, with particularly strong growth in the large European markets, France, Germany, the United Kingdom, Italy and Spain, where, as previously stated, Lundbeck increased its sales and marketing efforts significantly, which led to an expected growth in sales. Revenue from sales of CelexaTM in the USA, which includes partly royalties from sales in the United States and partly bulk deliveries, increased from DKK 40 million in the third quarter of 1998 to DKK 192 million in the third quarter of 1999. By the end of the third quarter of 1999, CelexaTM had been on the US market for 12 months, during which period the product has achieved market shares of 9.8% of new SSRI prescriptions and 8.3% of all SSRI prescriptions. With a market share of close to 10% over a period of just one year, CelexaTM is the most successful SSRI introduction ever on the US market, and the product has outperformed even the most optimistic expectations. Lundbeck's total costs, excluding tax and financial items, increased by 13% during the period.The sharp increase in turnover and a moderate increase in costs resulted in a significant increase in earnings during the third quarter of 1999. Profit before tax and profit after tax and minority shareholders increased by 42% to DKK 331 million and 44% to DKK 229 million, respectively. Financial review for the nine months to 30 September 1999 Turnover for the first three quarters of the year increased by 25% over the same period last year and totalled DKK 3.0 billion. Adjusted for products not marketed in 1999, turnover increased by 33%. These products are Serdolect, the antipsychotic, which Lundbeck voluntarily and temporarily suspended from its marketing programme, and non-CNS products returned on 1 January 1999 to Byk Gulden, our partner on the German market, in accordance with the contract provisions. As for the third quarter, the growth is attributable to significant increases in sales of Cipramil on all European markets and an extremely positive sales development of CelexaTM in the USA, Release No. 9, 12 November 1999 Interim report for the third quarter of 1999 Page 3 of 8.
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Daniel Vasella, MD Chairman & CEO . 916, 667 Urs Brlocher, JD a Head, Legal & General Affairs . 660, 000 Raymund Breu, PhD Chief Financial Officer 900, 000 Paul Choffat, JD Head, Consumer Health . 750, 000 Thomas Ebeling, Head, Pharmaceuticals . 1, 000, 000 1, 100, 000 Norman Walker, Head, Corporate Human Resources . 600, 000.
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Leep disturbances, including insomnia, excessive sleeping, and changes in sleep patterns, are frequent in patients with schizophrenia and many other psychiatric disorders. The actual process of sleep is also different in patients with schizophrenia compared with that in individuals with no psychiatric disorders. In addition, medications commonly given for psychosis can worsen excessive sleeping by sedating patients. Selecting a less sedating antipsychotic for patients with excessive sleeping and managing sleep disturbances carefully can improve outcome for antipsychotic-treated patients. SLEEP DISTURBANCES IN ANTIPSYCHOTIC-TREATED PATIENTS Sleep disturbances in schizophrenia have been well studied. Tandon et al.1 examined sleep disturbances in 40 patients with schizophrenia and found they had a longer sleep latency, a higher number of arousals during sleep, and increased periods of wakefulness after sleep onset compared with those in a nonpsychiatric control group, resulting in a lower sleep efficiency rating for the patients with schizophrenia. The control group had a 95% sleep efficiency, while drug-nave schizophrenic patients had a and clonazepam.
The Centers for Disease Control and Prevention CDC ; recommended that health care providers and parents postpone use of the rotavirus vaccine for infants until November 1999. Preliminary data show an increased incidence of intussusceptions in children receiving the vaccine. Rotavirus is the most common cause of severe diarrhea for children aged 335 months in the United States. Virtually all children have one or more rotavirus infections in the first five years of life. Rotavirus is responsible for approximately 500, 000 physician visits and 50, 000 hospitalizations annually. It is a seasonal disease in the US with the vast majority of the disease occurring in the winter and spring. The CDC will soon be collecting additional data to indicate whether the rotavirus vaccine increases the risk of intussusception. M-CARE encourages parents and caretakers of infants to contact their health care provider if the child develops symptoms of intussusception persistent vomiting, bloody stools, black stools, abdominal bloating or severe colic pain ; . Health care providers should be aware of the possible increased risk and consider this diagnosis among children with these symptoms. All cases of intussusception which occur following administration of the tetravalent rotavirus vaccine RRV-TV ; should be reported to the US Food and Drug Administration's FDA's ; Vaccine Adverse Event Reporting System VAERS ; by calling 800 ; 822-7967 or by visiting their website at fda.gov cber vaers report, for instance, citalopram 10mg.
And four is downright confusing. The USP Practitioners' Reporting NetworkSM USP PRN ; is receiving numerous reports concerning potential and actual errors involving the products Cerebyx, Celebrex, and Celexa. The similarity of the look, sound, and spelling of these names is confusing for physicians, pharmacists, nurses, and other health care professionals. Reports include confusion between combinations of two of the drugs or, in some cases, confusion among all three. Since this problem was initially reported in October 1998, nearly 10% of all incoming reports to USP PRN have involved the similar names of these products. To make matters more complex, USP received a report expressing concern that a dietary supplement, CerebraTM, could potentially be confused with the prescription products Cerebyx, Celebrex, and or Ccelexa and clonidine.
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1. Denton FT, Gafni A, Spencer BG. Requirements for physicians in 2030: Why population aging matters less than you may think [editorial]. CMAJ 2003; 168 12 ; : 1545-7. Laucius J. MD shortage to ease: report. Declining population means fewer doctors will be needed. Ottawa Citizen 2003 Jun 10; Sect A: 3. Dawes R, Willett J, Lofsky S, McNestry G, Gould M, Tepper J, et al. OMA position paper on physician workforce policy and planning. Ont Med Rev 2002; 69 4 ; : 17-28. Chochinov A, Adams O. Getting there from here! Prospects for a sustainable physician workforce [appendix to reports to General Council]. Canadian Medical Association 136th annual meeting; 2003 Aug 18-20; Winnipeg.
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Although research indicates that actuarial methods of risk assessment are superior to clinical methods in predicting violence Rice et al, 2002 ; , and although members of the court's clinical team have been trained in the use of the HCR-20 Violence Risk Assessment Scheme, the court opted not to administer any actuarial risk assessment instruments in its evaluations of offenders. One simple reason is time: completing an actuarial risk assessment would considerably lengthen the time required to complete a psychiatric evaluation and psychosocial assessment. But a more important factor was the court's determination that any potential decrease in the court's ability to predict violence would be more than compensated by the numerous and complex mechanisms in place for managing risks presented by individual offenders, which are discussed in detail in this section. 5 During the planning process, defense attorneys expressed concern that information disclosed during the evaluation process could be used against a defendant who opted out of or was excluded from the Brooklyn Mental Health Court. They feared that a defendant might make statements about the instant offense that could be used by the prosecutor at trial; they also feared that a judge might use a mental health professional's assessment of a defendant's potential risk of violence, or even the mere fact of a defendant's mental illness, to impose a more severe sentence. Representatives of the District Attorney's office sought to assure defense attorneys that they had not used comparable information in the prosecution of cases against defendants considered for participation in the Drug Treatment Alternative to Prison program or Treatment Alternatives for Dually Diagnosed Defendants program and that they intended to maintain that practice for the Brooklyn Mental Health Court. In drafting consents for the release of confidential information about psychiatric treatment, the planning team agreed to language permitting the Brooklyn Mental Health Court staff to redisclose such information to the defense attorney and the District Attorney's Office solely for purposes of establishing the defendant's eligibility for participation in the court and preparing a court-mandated treatment plan, thus limiting the prosecutor's ability to use any information obtained during the evaluation of a defendant in any proceeding outside of the Brooklyn Mental Health Court.
A doctor took a patient's verbal history and noted in the chart that the patient took "Cerebex" which was spelled wrong ; . The patient stated he was taking Cerebex, however, he actually took Celebrex. A pharmacist verified the order to be Celebrex. Although Cerebyx is an injectable product and the dosing may be different from Ceoexa and Celebrex, these medications may be confused when relying on a verbal patient history.
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Abstract 1766 IMPROVING QUALITY OF LIFE: THE EVOLUTION OF FIBROMYALGIA PROGRAM - COMPARISON OF 1-DAY BLITZ AND WEEKLY FORMATS Janet Jeffrey, Nadine Bellman, Lorna Bain, Marie Chambers, Pattrick Clifford, Ieva Fraser, Carter Thorne, Department of Nursing, York University TAP, York County Hospital ; , Toronto, ON, Canada People with fibromyalgia are faced with the unknown and limited effective treatment. The Fibromyalgia Program developed by The Arthritis Program at York County Hospital has evolved over 9 years. The purpose of this program evaluation was to compare outcomes Fibomyalgia Program participants and to determine whether the 1-day Blitz and weekly formats oncea-week 2-hour meetings until 1999 then 9 week format Blitz stopped ; of the program have similar outcomes. The data from over 100 women were evaluated. The sample was well educated, one third were working, average time since diagnosis was 2 years. Data were collected at the 1-day Blitz, and or at first and last sessions of the weekly format, and 6-12 months post program. Some participants attended the Blitz and the weekly format several months later. Despite the limitations of a retrospective chart review and changes in the timing and nature of outcome measures over time, the program participants who completed questionnaires prior to and following attending the Fibromyalgia Program reported that the program was effective. One caveate to consider is that those who completed follow-up data approximately one third of program participants ; may have been those for whom the program was most successful. The primary outcome measures were fitness distance walked stairs climbed, heart rate ; , self efficacy for pain and symptom control Self-Efficacy Scales ; , disease impact Fibromyalgia Impact Questionnaire ; , and health-related quality of life SF36 ; . Self efficacy improved slightly over the weekly program and was maintained at follow-up for those who attended the weekly group program. Impact of disease was slightly reduced over the length of the program and at follow-up. Quality of life also improved slightly over time and was maintained at follow-up for all scales: physical function, body pain, general health, vitality, social and mental health and cephalexin.
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DR WILLIAM F. MIELER. Addressing Dr Gil Grand's comments, we certainly share the concern of utilizing moxifloxacin as a single agent. With respect to the concerns of both Drs David Wilson and Travis Meredith regarding resistance, we would most likely recommend employing this antibiotic in combination with another antibiotic, most likely vancomycin. Of course there also are potentially adverse reactions related to these antibiotics inside the eye and we do not have combination data at the present time to answer these concerns. The resistance question is a difficult one to fully address. A manuscript recently published by Mino de Kaspar and colleagues looking at pre-operative conjunctival cultures showed only a 2% resistance of coagulase-negative staphylococci to the fourth generation fluoroquinolones Mino de Kaspar H, Koss MJ, He L, et al. Antibiotic susceptibility of preoperative normal conjunctival bacteria. J Ophthalmol 2005: 123: 39-44 ; . Dr Harry Flynn's unpublished data presented at the 2005 annual ARVO meeting, indicated that among 35 isolates, only 3 4ths of coagulase-negative Staphylococcal organisms were sensitive to the fourth generation fluoroquinolones. Why there is such a discrepancy between these two studies is not known. Concerning Dr David Wilson's comments regarding how drug resistance is reported, MIC90 levels versus just sensitive or resistant, I do not have the answer for that. Certainly more work is needed to ensure that moxifloxacin is a safe and effective combination therapy before it's employed intravitreally on a regular basis in humans.
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PRODUCT 19.4% 9.8% 9.4% LIPITOR 10MG PREVACID 30MG PRILOSEC 20MG CLARITIN 10MG LIPITOR 20MG ZITHROMAX 250MG PREMARIN 0.625MG ORTHO TRI-CYCLEN PREMPRO 0.625-2.5MG CELEBREX 200MG VIOXX 25MG ZYRTEC 10MG NORVASC 5MG FLONASE 50MCG GLUCOPHAGE 500MG PAXIL 20MG ALLEGRA 180MG ZOLOFT 100MG TOPROL XL 50MG NORVASC 10MG ZOLOFT 50MG ZESTRIL 10MG PROZAC 20MG CELEXA 20MG WELLBUTRIN SR 150MG FOSAMAX 70MG AMBIEN 10MG ZESTRIL 20MG PREMARIN 0.625MG ALLEGRA 60MG PRAVACHOL 20MG NASONEX 50MCG ZOCOR 20MG LIPITOR 40MG SYNTHROID 100MCG CLARITIN-D 24 HOUR 240-10MG LEVAQUIN 500MG CIPRO 500MG AUGMENTIN 875-125MG PRAVACHOL 40MG DIFLUCAN 150MG ALLEGRA-D 120-60MG PREMARIN 1.25MG CLARITIN-D 12 HOUR 120-5MG SYNTHROID 50MCG TOPROL XL 100MG SEREVENT 21MCG SYNTHROID 125MCG GLUCOPHAGE 1000MG FLOMAX 0.4MG.
If yes, approximate coverage or % of doctors who dispense: Are there pharmacies or medicine outlets in health facilities? Yes.
I. Bosgelmez, G. Guvendik. Department of Toxicology, Faculty of Pharmacy, Ankara University, Tandogan, 06100, Ankara-Turkey Chromium VI ; compounds, which have extensive industrial uses, have serious toxic, carcinogenic and mutagenic effects in human and animals. It has been suggested that reactive intermediates and free radicals generated during the reduction of Cr VI ; may be responsible for Cr VI ; toxicity. In this study, the effects of pre- or post-treatment of Taurine TAU ; on Cr VI ; -induced oxidative stress in the kidney tissue of Swiss Albino mice were investigated. It was observed that single intraperitoneal treatment with K2 Cr2 O7 20 mg Cr kg ; , as Cr compound, produced significant oxidative stress in this tissue. The level of thiobarbituric acid reactive substances TBARS ; was significantly elevated as compared to the control group p 0.001 ; . Non-protein thiols NPSH ; level and Cu, Zn-superoxide dismutase SOD1 ; and catalase CAT ; enzyme activities were reduced in the exposed group as compared to the control group p 0.01, p 0.05, p 0.001 respectively ; . TAU administration 1000 mg kg ; before or after Cr VI ; exposure resulted in a significant reduction in the TBARS levels p 0.001 ; . While NPSH level and CAT enzyme activity were restored only by TAU pre-treatment p 0.001, p 0.05 respectively ; . On the other hand, administration of the antioxidant before or after K2 Cr2 O7 caused a significant improvement in the SOD1 enzyme activity p 0.01 ; . In conclusion, TAU seems to exert both protective and antidotal effects and it can be suggested that TAU treatment might be beneficial in protecting against Cr VI ; -induced oxidative stress in mice kidney tissue. 426.
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Ues for the rest of your life. One hundred years ago some women associated menopause with the end of life. The average life expectancy for a woman born in 1900 was 50.7 years. Indeed, throughout history many women did not live long enough to go through menopause. It's easy to see why they connected menopause with death. However, advances in medicine and disease prevention have greatly increased life expectancy. A girl born in 1990 can expect to live nearly 79 years. This means that she will probably live a third of her life after menopause!
Mrs Rachel Webb MRPharmS, Dip Clin Pharm Mrs Webb has been a pharmaceutical adviser since 1991 in a number of FHSAs and HAs. Her main research interest, in which she has just completed an MSc, is the training and development needs of pharmacists to provide prescribing support to GPs.
From ulcerations caused by intraoral herpes simplex virus infection are outlined in Table 1. RAS is a multifactorial process, with the development of oral lesions influenced by trauma, smoking, stress, hormonal state, family history, food hypersensitivity, and infectious or immunologic factors.2 Fortunately, most cases of RAS can be managed palliatively with topical agents. A variety of over-the-counter preparations containing one or more active ingredients, including anesthetics, antimicrobials, wound cleansers, coating agents, and occlusive dressings, is widely available. Although many of these products reduce the pain and or shorten the duration of the disease, benefits are modest and attained typically in patients with RAS whose ulcers are shallow, relatively painless, and short in duration. A significant number of patients with RAS develop painful ulcerations that result in difficulty when speaking, eating, drinking, and performing routine oral hygiene Figure, A and B ; . Overthe-counter preparations are relatively ineffective for these patients; however, multiple topical and!
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