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590 CROSS-REACTIVITY OF ANTIBODIES TO ANTIGENS OF WOLBACHIA FROM FILARIAL NEMATODES WITH FILARIAL ANTIGENS OR WITH WOLBACHIA-ANTIGENS FROM ARTHROPOD PARASITES. Fischer, P, Jolodar, A, Bonow, I, Bandi, C, Brattig, N, Buttner, DW. Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany; Dipartimento di Patologia Animale, Igiene e Sanita Pubblica Veteruinaria, Universita di Milano, Italy. Alpha proteobacteria of the genus Wolbachia infect a large number of filarial parasites and a broad range of arthropods. In filarial parasites they live in a mutualistic relationship and have been shown as a target for chemotherapy. Furthermore, they have been suggested to contribute to pathogenesis of filariasis. Therefore, the specificity of selected Wolbachiaantigens was studied. An aspartate aminotransferase of the Wolbachiaof Onchocerca volvulus was identified and expressed as recombinant protein. Using a polyclonal rabbit antiserum the protein was localized in the endobacteria. Although, the protein has only 13% homology to the corresponding enzyme of the filarial host, a cross-reactivity between the filarial and the Wolbachia protein was found. A similar phenomenon was observed by analyzing the localization of a putative HtrA serine protease of the Wolbachia of O. volvulus using a polyclonal rabbit antiserum. Both antisera did also recognize antigens in filarial parasites shown to be not infected by Wolbachia such as Loa loa, O. flexuosa and Acanthocheilonema vitae. Antisera against the Wolbachia surface protein WSP-1 ; stained exclusively the endobacteria, indicating the absence of cross-reacting homologs in the filarial host. However, antiserum against the WSP of Wolbachia from the filarial worm Dirofilaria immitis detected also Wolbachia of the human arthropod parasite Tunga penetrans. These results show that both, Wolbachia and filarial antigens, can be detected by the same polyclonal antibodies, while antisera against the WSP did not stain filarial structures. Antisera against WSP label both Wolbachia of filarial as well as of arthropod parasites. ACMCIP abstract, because desyrel manufacturer.
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Rate that eligible members diagnosed with ADHD were referred for a social intervention or received a social intervention. Source: PCP medical records Parent Satisfaction Survey A survey instrument was developed by the State to assess parent satisfaction with treatment and improvement in the child's functioning. HMOs were instructed to survey the families of any child with an ADHD encounter during the study period. HMOs were directed to achieve a 30% response rate. Survey methodology was left to the HMO's discretion. The next three variables are derived from the survey. 1 ; Rate that the parents of eligible members diagnosed with ADHD were satisfied with their children's treatment. Source: administrative data 2 ; Rate that the parents of eligible members diagnosed with ADHD perceived improvement in their children's behavioral functioning after receiving services. Source: administrative data 3 ; Overall rate that parents of eligible members with ADHD were satisfied with treatment; and perceived improvement in their children's behavioral functioning after receiving services. Source: administrative data Demographic Variables By Member Race--White, African-American, Hispanic, American Indian, Asian, and other By SDA--Travis, Bexar, Lubbock, Tarrant, and Harris By HMO within SDA By service county within SDA see Table 1 below and mesterolone!
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MEDI 285 [1, 4]Diazepine[7, 8, 1-hi]indole derivatives as antipsychotic and antiobesity agents Hong Gao1, Gary Stack2, Boyd L. Harrison1, Hossein Mazandarani3, Jean Zhang3, Sachin Kalgonkar3, Sharon Rosenzweig-Lipson3, John Dunlop3, Terry Andree3, and Lee Schechter3. 1 ; Chemical and Screening Sciences, Wyeth Research, CN 8000, Princeton, NJ 08543, Fax: 732-274-4505, gaoh1 wyeth , 2 ; Medicinal Chemistry, Chemical and Screening Sciences, Wyeth Research, Princeton, NJ 08543, 3 ; Wyeth Neuroscience, Princeton, NJ 08543 5-HT2C agonists and partial agonists represent a novel therapeutic approach toward the treatment of schizophrenia. At present, the most widespread treatments for schizophrenia are the `atypical' antipsychotics, which combine dopamine D2 ; receptor antagonism with serotonin 5-HT2A ; receptor antagonism. Despite the reported advances in efficacy and side-effect liability of atypical antipsychotics over typical antipsychotics, these compounds do not adequately treat all of the symptoms of schizophrenia and are accompanied by problematic side effects including weight gain. Novel antipsychotics which are effective in treating the symptoms in schizophrenia without producing weight gain would represent a significant advance in the treatment of schizophrenia. A series of benzodiazocinoindoles I ; were investigated and several analogs found to be potent and selective 5-HT2C agonists and partial agonists with affinities in the 10 nM range. Herein we report the synthesis and SAR of these novel benzodiazocinoindoles and naprosyn and desyrel, because cesyrel font.
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Background: IVC filters are used to prevent pulmonary embolism PE ; . International guidelines1 suggest; absolute, relative and prophylactic indications for IVC filters in 311% of all patients with venous thromboembolism VTE ; . IVC filters should be removed once the risk of PE has passed. We wished to audit our institutions use of IVC filters. Firstly the indications and management of IVC filters, and secondly who is recommending treatment and managing these patients. Methods: IVC filter placement was assessed at a regional vascular centre, where over 600 new cases of VTE are see each year. All patients who underwent IVC placement were reviewed. Indication for IVC filter, concurrent management and duration of placement were assessed. Secondly consultants and registrars in acute medicine and surgery were assessed by a questionnaire on indications and management of IVC filter use. Results: In five years 36 IVC filters were placed, significantly lower than the anticipated 90330. The majority were for absolute indications; contraindication to anticoagulation 12 ; and recurrent VTE 6 ; . Relative indications 8 ; were mostly iliac or IVC thrombus. Ten were prophylactic for patients with trauma or about to undergo surgery. Seven different specialities managed follow up. Most cases could have undergone later IVC filter removal. Only 12 filters 30% ; were removed from patients; following prophylactic indication 7 ; , once risk of PE had reduced 2 ; or anticoagulation could be started 3 ; . Questionnaire results showed confusion over indications and management of IVC filters. Conclusion: IVC filters are inserted in line with international guidelines however they are probably under-used in PE prevention. Recommendation, management and follow-up, in particular IVC filter removal, should be coordinated by one speciality and nexium.
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Objectives: Streptococcus pneumoniae Pnc ; causes a substantial burden of disease in infants and adults in Europe. With the imminent licensing of new Pnc conjugate vaccines, it is imperative to establish the pre-vaccination epidemiology of Pnc infection to enable policy makers to implement the most appropriate vaccination strategy. We propose to collect data with standardised methodology to determine the actual incidence of Pnc carriage and Pnc invasive disease in a range of European countries and the risk factors for Pnc invasive disease. We will also develop new laboratory methodology to measure serological correlates of natural and vaccine induced immunity. Utilising this data in tailored mathematical models, we will predict the impact of a variety of vaccination strategies on Pnc infection and disease and undertake an economic evaluation of these alternative interventions to enable the design of an optimal vaccination strategy. Project Co-ordinator: Terhi Kilpi Kansanterveyslaitos, Department of Vaccines Helsinki, Finland Tel: + 358-9 47448678 Fax: + 358-9 47448675 E-mail: Terh.Kilpi ktl.fi and famvir.
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