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VII. PERIODICALS. There are many specialized tax journals in Spain. The libraries of several Spanish universities have undertaken a common project in order to offer an online service of research journals summaries not only law journals, but other fields as well ; . They also offer free e-mail service of new arrivals of summary of the journals previously earmarked by the researcher. This joint project is named "dialnet", and it is available at: : dialnet rioja These are some of the Spanish tax law journals: Revista Espaola de Derecho Financiero REDF ; , Civitas-Thomson, Madrid orientation: research ; : civitas Crnica Tributaria CrT ; , Instituto de Estudios Fiscales, Madrid orientation: research; some articles are freely available online ; : ief : ief Publicaciones Revistas Cronica%20Tributaria CronicaTributaria Tribuna Fiscal TF ; , CISS-Praxis, Valencia orientation: professionals-research ; : ciss Quincena Fiscal QF ; , Aranzadi-Thomson orientation: professionals-research ; : aranzadi Jurisprudencia Tributaria JT ; , Aranzadi-Thomson orientation: research-professionals; court rulings on tax matters, some with commentary ; : aranzadi Revista de Tributacin, Centro de Estudios Financieros CEF orientation: researchprofessionals ; : cef Nueva Fiscalidad orientation: research ; : premium.vlex Revista Tcnica Tributaria RTT ; orientation: professionals-research ; : aedaf Carta Tributaria CT ; orientation: professionals-research; repertoire jurisprudence, administrative doctrine ; Impuestos orientation: professionals ; : publicaciones.laley Prepared by Santiago Ibez Marsilla, Profesor Titular de Universidad, Universidad de Valencia SPAIN ; . : uv ibanezs english index and fosamax.
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ACTION BY 22. APOLOGIES AND WELCOME Apologies for absence were intimated on behalf of Dr T Beattie, Dr F Elliot, Dr C Forrest, Dr J Fox, Mr A Hunter, Mrs A Lee, Mrs M A Mackie, Dr C McKean and Dr G Smith. The Chairman welcomed Ms Jann Davison, Chief Pharmacist, Stirling Royal Infirmary who was attending as an observer for Forth Valley Health Board ; to her first meeting of the Committee and glucophage.
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Be a role for assessing intratumoral DPD activity, since high enzyme activity suggests poorer outcomes with 5-FU. The increasing availability of DPD inhibitors may make assessment of metabolizer status redundant. Overall, there are too many unknowns for screening for DPD to be recommended routinely in the clinic. Formal pharmacoeconomic analyses need to be performed to see whether prospective genotype testing is worthwhile. E. Uridine Diphosphate Glucuronosyltransferase 1A1 Uridine diphosphate glucuronosyltransferase 1A1 UGT1A1 ; belongs to the uridine diphosphate glucuronosyltransferase superfamily and gained recognition recently as the first pharmacogenetic test to achieve FDA approval for use in conjunction with a specific drug irinotecan ; : fda.gov bbs topics NEWS 2005 NEW01220 ; : twt company pressreleases 2005 Aug 22 2005 ; . Variants in UGT1A1 have been associated with greater exposure to the active cytotoxic metabolite of irinotecan Sai et al., 2004 ; and elevated risk of the major dose-limiting toxicities of diarrhea and myelosuppression Ando et al., 2000 ; . Irinotecan is widely used, particularly in the treatment of colorectal and lung cancers. It is a prodrug that is metabolized by carboxylesterases to the active topoisomerase inhibitor 7-ethyl-10-hydroxycamptothecin SN-38 ; and by CYP3A4 to inactive metabolites. Thereafter, SN-38 is glucuronidated by UGT1A1 Iyer et al., 1998 ; with the resultant SN-38 glucuronide excreted into the intestine via bile. Enteric bacterial -glucuronidase regenerates SN-38, which can be reabsorbed into the systemic circulation. Liberation of SN-38 within the gut may cause local tissue damage and diarrhea. The activity of UGT1A1 varies widely, with an in vitro study demonstrating a 17-fold variation in SN-38 glucuronidation Iyer et al., 1999 ; . UGT1A1 * 28 is the variant most frequently implicated in defective SN-38 glucuronidation and involves an extra thymine-adenine TA ; repeat in the TATA section of the UGT1A1 promoter [i.e., TA ; 7TAA instead of TA ; 6TAA in the wild type]. It is also the primary cause of Gilbert's syndrome Bosma et al., 1995 ; consistent with the role of UGT1A1 as the principle enzyme responsible for bilirubin glucuronidation Bosma et al., 1994 ; . This variant occurs commonly, with the homozygous genotype found in 5 to 15% of Europeans, 10 to 25% of Africans and South Asians, and 1 to 5% of Southeast Asians and Pacific Islanders Premawardhena et al., 2003 ; . Initial case reports documented severe neutropenia in patients with Gilbert's syndrome receiving standard doses of irinotecan Wasserman et al., 1997 ; . Subsequently, studies reported an increased risk of toxicity in homozygotes for UGT1A1 * 28 compared with homozygotes for UGT1A1 * 1 individuals heterozygous for these alleles were sometimes included in the latter comparator group ; . These included a 5-fold higher risk of severe neutropenia and diarrhea Ando et al., 2000 ; , 3-fold and hydrochlorothiazide.
Medication cost is a significant predictor of noncompliance. Part D prescription coverage may improve adherence among patients who were noncompliant for financial reasons prior to benefit implementation; however, noncompliance may reemerge during the coverage gap. Plans should actively monitor for lapses in adherence during the coverage gap, and continue the processes put in place to encourage adherence and persistence during this period.
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After decades of illegal activity, it appears as though the Department of Justice is finally attempting to curb the off-label promotion of prescription drugs by pharmaceutical companies. "Off-label" promoting is the term used to describe the practice of promoting or recommending a FDA-approved product outside of its approved indications. Recently, the government announced two settlements that seem to show a shift in attitude toward offlabel promoting and that the Department is attempting to alter the way companies will promote and market their pharmaceutical products in the future. The most recent settlements involve drug manufacturer Eli Lilly and Co. and a Swiss biotech company called Serono S.A. In December 2005, Eli Lilly agreed to plead guilty to a single misdemeanor count related to the marketing of Evista. Evists has been approved by the FDA for the treatment of osteoporosis in post-menopausal women. In addition to pleading guilty, Eli Lilly also agreed to pay $36 million to settle both criminal and civil charges stemming from the company's marketing of Evista. In October 2005, Serono agreed to plead.
40 Tangkanakul C, Counsell C, Warlow C. Local versus general anaesthesia for carotid endarterectomy Cochrane Review ; . In: The Cochrane Library, 4. Oxford: Update Software, 2000. 41 Counsell C, Salinas R, Warlow C, Naylor R. Patch angioplasty versus primary closure for carotid endarterectomy Cochrane Review ; . In: The Cochrane Library, 4. Oxford: Update Software, 2000. 42 Counsell C, Warlow C, Naylor R. Patches of different types for carotid patch angioplasty Cochrane Review ; . In: The Cochrane Library, 4. Oxford: Update Software, 2000. 43 Crawley F, Brown MM. Percutaneous transluminal angioplasty and stenting for vertebral artery stenosis Cochrane Review ; . In: The Cochrane Library, 4. Oxford: Update Software, 2000. 44 Crawley F, Brown MM. Percutaneous transluminal angioplasty and stenting for carotid artery stenosis Cochrane Review ; . In: The Cochrane Library, 4. Oxford: Update Software, 2000. 45 Counsell C, Salinas R, Naylor R, Warlow C. Routine or selective carotid artery shunting for carotid endarterectomy and different methods of monitoring in selective shunting ; Cochrane Review ; . In: The Cochrane Library, 4. Oxford: Update Software, 2000. 46 Stroke Unit Trialists' Collaboration. Organised inpatient stroke unit ; care for stroke Cochrane Review ; . In: The Cochrane Library, 4. Oxford: Update Software, 2000. 47 Langhorne P, Dennis MS , Kalra L, Shepperd S, Wade DT, Wolfe CDA. Services for helping acute stroke patients avoid hospital admission Cochrane Review ; . In: The Cochrane Library, 4. Oxford: Update Software, 2000. 48 Early Supported Discharge Trialists. Services for reducing duration of hospital care for acute stroke patients Cochrane Review ; . In: The Cochrane Library, 4. Oxford: Update Software, 2000. 49 Lincoln NB, Majid MJ, Weyman N. Cognitive rehabilitation for attention deficits following stroke Cochrane Review ; . In: The Cochrane Library, 4. Oxford: Update Software, 2000. 50 Majid MJ, Lincoln NB, Weyman N. Cognitive rehabilitation for memory deficits following stroke Cochrane Review ; . In: The Cochrane Library, 4. Oxford: Update Software, 2000. 51 Price CIM, Pandyan AD. Electrical stimulation for preventing and treating post-stroke shoulder pain Cochrane Review ; . In: The Cochrane Library, 4. Oxford: Update Software, 2000. 52 Forster A, Smith J, Young J, Knapp P, House A, Wright A. Information provision for stroke patients and their caregivers Cochrane Review ; . In: The Cochrane Library, 4. Oxford: Update Software, 2000. 53 Greener J, Enderby P, Whurr R. Pharmacological treatment for aphasia following stroke Cochrane Review ; . In: The Cochrane Library, 4, 2001. Oxford: Update Software, 2000. 54 Greener J, Enderby P, Whurr R. Speech and language therapy for aphasia following stroke Cochrane Review ; . In: The Cochrane Library, 4. Oxford: Update Software, 2000. 55 Sellars C, Hughes T, Langhorne P. Speech and language therapy for dysarthria due to non-progressive brain damage Cochrane Review ; . In: The Cochrane Library, 4, 2001. Oxford: Update Software, 2000.
Common osteoporosis and cholesterol-lowering drugs combine for uncommon power A drug commonly used for osteoporosis adds cholesterol-lowering power to a common cholesterol medication, according to a new study being presented on Friday, June 18, at The Endocrine Society's 86th Annual Meeting in New Orleans. Researchers say that this finding is important for postmenopausal women because osteoporosis and high cholesterol are two of the most common diseases affecting this group. Cardivascular disease due to high blood cholesterol is a major cause of death in women. Osteoporosis is a major cause of disability in women. Finding a drug combination that can benefit both conditions is a valuable advance in clinical treatment by endocrinologists, primary care physicians, and cardiologists. Dr. William Insull, Jr., of Baylor College of Medicine and Methodist Hospital in Houston, and colleagues hoped to find such a combination in the osteoporosis drug raloxifene Evsita ; and the cholesterol-lowering medication simvastatin Zocor ; . Therefore, they examined 94 postmenopausal women with moderately elevated cholesterol in four U.S. research clinics. The women were given either drug alone or both together for 12 weeks and had their cholesterol levels remeasured. Both drugs given together lowered "bad cholesterol" known as low-density lipoprotein, or LDL more than either did given alone. Also, both drugs together raised "good cholesterol" called high-density lipoprotein, or HDL neither of which achieved this alone. These two effects are favorable. Both drugs appeared to be safe, alone and together, in this small study. The researchers note that a large study in postmenopausal women is currently underway to investigate whether raloxifene can reduce heart attacks and deaths from heart disease. The cholesterol-lowering ability shown in this study, they add, may help to understand how raloxifene could reduce heart disease. This study was funded by Eli Lilly & Co.
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