From the Department of Medicine, Addenbrooke's Hospital, Cambridge, UK. Address correspondence to D.R.W.J., Box 157, Department of Medicine, Addenbrooke's Hospital, Cambridge CB1 2SP, UK. E-mail: dj106 cam.ac.
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600 mg day ; 1, equivalent to 39 mg kg ; 1 day ; 1. The median amount of the 5% LA cream used by the test subjects in this study was approximately 1 g on half the face per day, corresponding to15 mg kg ; 1 day ; 1 of LA for the whole face. With an average weight of 65 kg, this represents a dose of approximately 100 mg day ; 1 of LA. Thus, full face topical treatment with a 5% LA cream applied twice daily does not reach the lower range of doses used for systemic treatment. Concerning clinical safety, allergic skin reactions are among the few side-effects previously reported25 after systemic administration. In this study we have noticed that local irritation on application of 5% LA is common during the first weeks of treatment, but eventually reduces and disappears in the vast majority of cases Table 1 ; . However, the side-effects commonly seen in patients treated with retinoic acid, such as a scaly erythema combined with swelling of the skin, seem to be a rare event in topical LA-treated subjects. In this study we have used four different assessment methods to document the effect of topical LA treatment on the skin. Two of these methods are subjective, the photographic evaluation has to be considered as a semiobjective and the laser profilometry as an objective method. The global assessment of the results obtained, independently of the method used, show a similar pattern. In this study no age-dependent pattern of improvement was detected statistically. This was probably explained by the relatively few subjects in each age group. In conclusion, 12 weeks of 5% LA in the tested cream vehicle seems to improve several clinical characteristics related to photoageing of the facial skin. Further studies to elucidate possible mechanisms, optimal dosage and treatment periods are warranted.
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Stensen and Almberg w22x found no differences in age at menarche or age at first pregnancy in comparison with the normal population. There was a higher rate of spontaneous abortion, menstrual disturbances, pelvic inflammatory disease and ovarian pathology. Peterson et al. w23x found no variation between controls and a cohort of 44 JIA sufferers in rates of marriage, divorce, pregnancy or miscarriage. The percentage of women patients who had been advised by their physicians against becoming pregnant was 12.9 compared with just 1.4% of the age-matched controls. Musiej-Nowakowska and Ploski w24x described good outcomes for pregnancy in the oligoarticular JIA group with pregnancy-induced amelioration of disease activity, but post-partum flare in 52%. Individuals in the study group were more likely than their siblings to be single and living outside a stable partnership. The proportion of patients married to date is lower, but individuals with JIA may be deferring marriage to ensure that their partner is the right person to also become a potential carer. Deferred marriage is suggested by the fact that few patients married before the age of 25 yr, but a high number of patients enter a stable relationship between the ages of 35 and 45 yr. The number of individuals becoming pregnant was lower than in comparative cohort studies and the general population. There were fewer individuals in a stable relationship, which may have had an effect on the total number of offspring. The disability in the study group may have reduced the number choosing to have children. There was also infertility due to early menopause or azoospermia, but this occurred in only a small proportion of the study group and there was a minimal effect on the number of pregnancies. The reported miscarriage rate was comparable to that in the general population. Early liaison with the obstetrician is important, particularly in view of the high proportion of patients with either poor hip abduction or small stature who had their babies by Caesarean section 78.9% ; and who had either poor hip abduction or short stature. The level of satisfaction with an individual's social support was high. The majority of patients thought and gatifloxacin.
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Kim, J. Y. and M. Fendrich 2002 ; . "Gender differences in juvenile arrestees' drug use, self-reported dependence, and perceived need for treatment." Psychiatr Serv 53 1 ; : 70-5.
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Figure. Monthly total spending on attention-deficit hyperactivity disorder medications for children aged 18 years and younger and indomethacin and grisactin.
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Dermatologica der Corticoidklasse IV; Salbe, Fettsalbe Cortisoncreme, - salbe, - fettsalbe, entzndungshemmend, juckreizstillend, antiallergisch PEGyliertes G-CSF; 1 x 6mg Chemotherapyzyklus G-CSF; 1ml 300 g 30 Mio IE ; Amp., 1, 6 ml 480 g 48 Mio IE ; Vit.B-Komplex; Amp. zu 100 mg 100 mg 1 mg Toxin des Clostridium botulinum. Ind.: Torticollis Antiepileptikum; auch bei bipolaren manischen und depressiven Phasen sowie analgetische Potenz diabetische Neuropathie, PostzosterNeuralgie ; ! 300 mg, 400 mg, 600 mg, 800 mg Kaps. Dosierung: Beginn mit 300 mg 1. Tag: 0 0 1, 2. Tag: 1 0 1, ab Tag: 1 Antiepileptikum Grand mal ; , Trigeminusneuralgie, Manie, Alkoholentzugssyndrom, diabetische Polyneuropathie Protonenpumpenhemmer, Refluxsophagitis; 20 mg, 40 mg Tabl. Antifibrinolyticum; rt-PA - Antidot Zytostatikum, Alkylantium Zytostatikum, Antimetabolit uerst potenter Vasodilatator; die Wirkung setzt innerhalb von 2-3 Minuten ein und hlt fr -1 Tag lang an. Nebenindikation: Insulinom Nebenwirkung: Hyperglycmie Vasodilatator arteriell + vens Wirkung setzt sofort bei Infusionsbeginn ein und sistiert sofort nach Infusionsende CAVE: enthlt CYANID-Ionen; MDT: 200 mg max. 500 g min, max. 6 Std. d mit 500 g min Nicotinprparat zur Raucherentwhnung; 1 mg Lutschtabletten; 2 mg, 4 mg Kaugummi, 10 mg, 20 mg, 30 mg TTS Cardioselectiver 1-Blocker ohne ISA + Ca + Antagonist; 50 mg 20 mg Kaps. 1 0 1 mg 10 mg Niften mite Kaps. max. 2 0 2 ; -Antagonist; fhrt zu einer Erweiterung der Gefe angeblich ohne Steal-Effekt ; und wirkt direkt an den Neuronen; Prophylaxe cerebraler Vasospasmen, hirnorganisches Psychosyndrom, degenerative Hirnleistungsstrungen; 3x10 mg die Neuroleptikum; Dibenzothiepin. Schizophrenie, Altersverwirrtheit. Ausgeprgt antipsychotisch. 25 mg, 50 mg, 100 mg Drg. Dosierung: je nach Symptomatik 75 150 mg die; bei Altersverwirrtheit: 25 mg 0 0 1 Anfallsprophylaxe der AP; 5 mg 10 mg 15 mg, von 19.00 - 7.00 Uhr AP - Anfall; Seite 41 66.
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Table1: Frequency of the isolated fungi from roots of cowpea plants showing root rot disease symptoms at different locations in Noubaria province. Frequency of isolated fungi % Noubaria F. solani R. solani M. phoseolina F. oxysporum Pythium spp. Sclerotium rolfsii Total El-Boustan 27.3 18.2 22.7 * ; 4 ; 5 ; 35.3 17.6 29.4 ; 3 ; 5 ; Malk 36.3 18.1 0 18.1 15.2 44 ; 2 ; 2 ; 7.6 23 ; 1 ; farm 22.2 33.3 22.2 0 11.1 12.5 2 ; 3 ; 2 ; 29.2 18 23.6 ; 13 ; 17 ; Samples were collected during 60 days of growing season. * Number of isolates.
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