The Endocrine Society Unveils Recommendations for Increasing Minority Participation in Clinical Research The Endocrine Society has engaged in a continuing project to improve the participation of racial and ethnic minorities in clinical research. The Society's recommendations, developed by a task force of thought leaders on the topic, were released during a special program during ENDO 07. The task force comprised Society members and non-member representatives from each of the stakeholder groups that have a vested interest in the problem, including researchers, community leaders, the pharmaceutical industry, and government agencies. The project is an initiative of the Government Relations Committee GRC ; and is funded in part by a grant from the Robert Wood Johnson Foundation. Dr. Maria Alexander-Bridges, a member of the GRC, spearheads the effort.
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ACRRM student member Brad Murphy 4th year JCU Medical School ; has been awarded the "2003 AMA Individual Contribution to Healthcare in Australia" Award. Mr Murphy has dedicated a significant part of his life to the health care system, particularly rural health, having previously worked as a qualified paramedic in rural Australia before starting his medical studies. In June 2002, Mr Murphy launched ARRESTOR Australian Rural and Remote Emergency Skills and Training & Online Resource ; at the Inaugural Pacific Rim Indigenous Doctors Congress. ARRESTOR is a unique not for profit project and serves as an online resource to Rural and Remote Australians who may be challenged in accessing formal first aid training programs due to their geographic locality. To find out more about ARRESTOR visit emergencymedicine .au. Mr Murphy will be travelling to Brisbane this week to accept the award and cinnarizine, because augmentin.
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Within-patient correlation across time was addressed by an autoregressive first-order ; model for the covariance structure. Missing data were mostly intermittent, and we assumed them to be missing at random. The normality assumption was rarely satisfied in either group at any week. However, at least 34 observations were recorded per group per week and the sample sizes were well-balanced, so we used the mixed-model analysis. We analyzed models with a single covariate baseline diarrhea, constipation, abdominal pain, or bloating severity score ; . The covariate models did not improve the fit nor did they change the substantive results. Hence, we presented the simpler no covariate ; model results. We used a similar mixed-model approach to assess the secondary end points of abdominal pain, bloating, diarrhea, and constipation. Within-patient correlation was modeled by an autoregressive covariance structure. The normality assumption was rarely satisfied for the diarrhea outcome, with a similar floor effect for the primary outcome. The pain and constipation outcomes occasionally satisfied the normality assumption. The bloating outcome was usually compatible with a sample from a normal distribution. At least 34 observations were available in each group at each week, and good balance was achieved across groups. Since abdominal pain seemed higher in the rifaximin than in the placebo group Table 2 ; , we conducted further analysis using pain as a covariate. While baseline constipation was slightly lower in the rifaximin group, we observed no interaction when constipation was a covariate. All values were expressed as means SD ; . We set statistical significance at a P value less than 0.05. We determined statistical analysis by using SAS, version 9.1 SAS Institute, Cary, North Carolina and cisapride.
Showing by NGOs. Some of the most significant organizations that are working to reduce the stigma of HIV AIDS include Dawn of Hope, Save Your Generation and Mekdim. Until the problem of stigma is overcome throughout the country, it will be difficult to achieve significant behavioral change, the key to reversing the prevalence rate of the disease. Evolution of Ethiopia'HIV AIDS s Program Senior Ethiopian officials acknowledge privately that the country was slow to attack the problem of HIV AIDS. Once engaged, the government emphasized prevention and communication. This was a reasonable approach. Ethiopia has established some 12, 000 anti-AIDS clubs in schools and communities throughout the country. NGOs, aided by funding from international organizations and bilateral donors, joined with religious organizations and civil society groups to get out the word on the threat posed by the disease. Posters in various languages can be seen throughout Ethiopia. The topic is discussed frequently on government radio and television. Local communities organize antiAIDS marches. As a result, the overwhelming majority of Ethiopians is now aware of the existence of the disease. The other priority of the government is to expand and improve the health care delivery system so that it can cope with the crisis. Minister of Health Kebede Tadesse emphasized in a meeting with the American NGO, People to People, early in 2004 that there must be a significant increase in the capacity, both personnel and infrastructure, of the health care system before it will be possible to control the pandemic. This is a reasonable, but very expensive, goal. It will require considerable external funding and intelligent and innovative implementation by the government to ensure that the care reaches areas beyond Addis Ababa and a few major towns. It must also be handled in a way so that trained personnel do not quickly migrate to other countries where pay is higher and 69.
As there are no known in i o substrates for MEK other than Erk1 and Erk2. Our results demonstrate that the Erk cascade is necessary and sufficient for the co-ordinated induction by insulin of Fra-1 mRNA expression via the activation of the fra-1 promoter ; , and of phosphorylation of the Fra-1 protein. While insulin activates the Erk cascade in most cell types, it is becoming clear that the phosphoinositide 3-kinase pathway is a major pathway in the regulation of metabolic events by this hormone. Furthermore, the Erk cascade may be activated to a greater extent in CHO.T cells than in hepatocytes, adipocytes or muscle cells. However, as we see Erk-cascade-dependent Fra-1 induction in adipocytes, this pathway is likely to be important in more physiologically relevant cells. Insulin-induced Fra-1 mRNA expression and phosphorylation of the Fra-1 protein are both sustained for at least 24 h after insulin stimulation. While this is consistent with the fact that activation of the AP-1 complex by insulin is also sustained for at least 24 h [5], the precise contribution of Fra-1 induction and phosphorylation to the overall activation of the AP-1 complex remains to be established. Young et al. [9] have recently reported that PMA can transactivate Fra-1, but others have failed to find a transactivating domain on Fra-1 [8]. In addition, others have proposed that Fra-1, and the related transcription factor Fra-2, may act as repressors of the AP-1 complex [26, 27]. Thus the precise role of Erk-dependent phosphorylation and induction of Fra-1 in the regulation of the AP-1 complex requires much further investigation. This work was supported by grants from the Medical Research Council and Diabetes UK J. M. thank Tom Harding and James Uney University of Bristol ; for their advice and assistance with the construction of the adenoviral vectors. We are also grateful to Jackie Webb and Elizabeth Aitken for technical assistance and propulsid.
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Paraoxonase 1 PON1 ; seems to have a relevant role in detoxifying processes and in atherosclerosis. The aim of this study was to determine PON1 activity, the total antioxidant capacity, as well as entire lipid profile in children for screening of possible risk of atherosclerosis development. Serum PON1 arylesterase paraoxonase activities were determined spectrophotometrically. The total antioxidant capacity of the serum was measured by TEAC method. Parameters of lipid profile were analyzed by routine laboratory methods. It has been shown that PON1 arylesterase paraoxonase activities were very similar to values found in adults. In children, no significant correlation between PON1 arylesterase activity and HDL was observed. PON1 paraoxonase activity correlated only with atherogenic index. PON1 arylesterase activity was significantly higher in girls than in boys. The antioxidant capacity was inversely related to the body mass index. In this study, PON1 activity was determined in healthy children aged 11 to 12 years and we found a similarity in PON1 activities of children and adults. Moreover, the results of our study support the hypothesis that higher body weight of children may contribute to a greater risk for development of atherosclerosis in which oxidative stress plays a role. Key words Atherosclerosis HDL Lipid peroxides Paraoxonase 1 TEAC.
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BY NON-POLICE PERSONNEL ; The basic objective of crime scene protection is to preserve physical evidence that may be used to develop investigative leads and to prosecute defendants in court. Physical evidence, therefore, must be protected from accidental or intentional alteration from the time it is first discovered to its ultimate disposition at the conclusion of an investigation. Often emergency medical service personnel are the first to arrive at potential crime scenes. EMS personnel may be unaware that the incident which necessitated the request for medical aid is a result of a criminal act. While emergency aid may be imperative, medical personnel should exercise extreme caution in approaching scenes suspected or known to involve any violent act. Sniper incidents have often resulted in multiple injuries among those trying to rescue the victim. Responding emergency personnel must consider their own safety as well as the methods they will use in aiding victims. Personnel should consider evidence preservation and crime scene protection while enroute to such an emergency. While saving life is paramount, personnel should do all they possibly can do to prevent the lost of related evidence. There are two INITIAL types of mistakes which damage crime scenes: Errors of commission and errors of omission. Errors of commission: occur when citizens, witnesses, officers, or emergency personnel smear fingerprints, step on evidence, add their own fingerprints, rearrange the scene, drop cigarette ashes and butts at the scene, etc. Any time anyone destroys existing evidence or adds "evidence" cigarette butts ; , a serious mistake has damaged the crime scene. Errors of omission: occur when personnel fail to notice the scent of perfume or cigar smoke, fail to listen to persons standing near the scene discussing the crime, or fail to take efforts to protect existing evidence which may otherwise be destroyed. Most errors in either category are unintentional, but they still complicate the investigation. A brand of cigarettes determined from butts found at the scene may be important, but if they were left by an officer or a paramedic, they are merely a waste of time, money and effort to analyze. Being aware of the problems commonly found at scenes and the needs of the investigating officers should help to prevent some of these difficulties.
Fig. 3. Leading causes of Years of Life Lived with Disability YLDs2000; adapted from WHO Mental Health Report 2001.
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