Pharmaceuticals Division Our core Pharmaceuticals business sustained above market net sales growth throughout the year to deliver an 18% rise in net sales 11% in local currencies ; . We moved up to the number five position in the global health care ranking based on November 2003 IMS data ; as we captured further segment share in the key US market net sales: + 15% in US dollars ; , in Japan net sales: + 23%; + 14% in local currencies ; , the second largest single market, as well as in Europe net sales: + 25%; + 6% in local currencies ; . Based on latest available data IMS ; , our overall share of the global health care market rose to 4.4% in 2003. Our cardiovascular + 36%; + 29% in local currencies ; and oncology franchises + 36%; + 26% in local currencies ; continued to be the main drivers, led in particular by the flagship brands Diovan, Lotrel, Lescol, Gleevec Glivec, Zometa and Femara. Newly launched products made further in-roads; Zelnorm Zelmac generated net revenues of $165 million, with US total and new prescriptions growing 32% in the fourth quarter. Meanwhile, net sales of Elidel reached $235 million, as the product extended its position as the number-one branded eczema treatment worldwide. Primary Care Diovan + 46%; + 38% in local currencies; US: + 42% ; became in 2003 the world's leading angiotensin receptor blocker ARB ; and continued to capture further market share from its competitors. With the heart failure indication approved in more than 40 markets, the flagship brand continued to outpace its fast-growing ARB market segment, with year-to-date net sales in the US surpassing the $1 billion mark by December. The fourth quarter was marked by the publication of the VALIANT mega-trial at the American Heart Association Scientific Session. The results showed that Diovan reduces the risk of death by 25% in post-myocardial infarction patients. A supplemental new drug application based on these results was filed in the US. Diovan HCT valsartan + hydrochorothiazide ; became the second most prescribed product in the combination ARB segment mono and combination therapy ; in the US. This rapid growth was powered by the roll-out of new dosage forms, the heart failure indication and new treatment guidelines. In Germany, the flagship brand secured the number-one rank, buoyed by the success of Co-Diovan 160 12.5 mg. Lotrel US: + 20% ; , the leading combination treatment for hypertension, posted strong full-year prescription growth while fourth-quarter net sales were spurred by a disease awareness campaign launched in August. Overall, the brand steadily gained market segment share as a result of Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure JNC7 ; guidelines recommending more aggressive treatment; a focus on patients who are not controlled by ACE inhibitors and calcium channel blockers; and the successful launch of the new dosage strength, which add efficacy and dosing flexibility. Lewcol + 27%; + 18% in local currencies; US: + 19%; cholesterol reduction ; continued strong net sales growth driven by proven benefits in high-risk patients, the successful rollout of the XL extended release ; formulation in France, Italy and Spain and the launch of the secondary prevention indication in the US. Trileptal + 42%; + 39% in local currencies; US: + 43%; epilepsy ; clearly outpaced its market. In August, the FDA granted approval for the use of Trileptal as monotherapy in children. Trileptal was now indicated for the treatment of partial seizures as a monotherapy and adjunctive therapy in adults and children of 4 years and upwards.
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Means that the objective accuracy of decisions on `physician-assisted suicide' and euthanasia in this category of patients cannot be certified. One important psychological issue, which parallels these views but applies to all cases of physician-assisted suicide and active euthanasia, is that decisions on these issues may be influenced by unintentional and even unconscious biases. One example of this phenomenon was presented in a recent study in which Swedish jurors were presented with a case description of a severely brain-damaged patient who was taken out of a respirator in the presence of muscle-relaxing drugs. The jurors were, most likely out of concern for the patient, generally supportive of euthanasia. However, since we varied the gender of the patient, as presented in the case description, we were also able to see that both male and female jurors tended to be most supportive of this kind of euthanasia when it was administered to a patient who belonged to the opposite gender Sjoberg & Lindholm, 2003 ; . Sjoberg Swedish jurors thus tended to be more impressed by the futility of the life of patients who were in important respects dissimilar to themselves. Not only psychiatric, but almost all clinical decision-making is to a certain extent tentative and subject to the corrective forces of expectation and further empirical observations but decisions that lead to the active and intentional termination of the life of a patient are not. We believe that this fact, which was also indirectly addressed by Kelly & McLoughlin, is important not only to the discussion of whether physician-assisted suicide should be administered to psychiatric patients but also to the discussion of whether physicians should engage in euthanasia and physician-assisted suicide and whether psychiatrists should take the risk of sanctioning such activities by assessing the mental status of potential subjects of such interventions.
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GlaxoSmithKline's three year grant of $555, 000 to the United Way of Southeastern Pennsylvania will create more effective healthcare delivery at the United Way's 91 member agencies. GlaxoSmithKline's International Impact Awards acknowledge and reward excellence in the non-profit healthcare community, in the Greater Philadelphia area. Ten winners each received $40, 000. Around GlaxoSmithKline's facilities in North Carolina community relations staff work to address issues that affect employees, their families, and their communities. Here, GlaxoSmithKline supports programmes in health, education, arts, and civic affairs: Promising Practices, which supports the prevention and treatment of chronic diseases that affect low-wealth communities, received $60, 000 over three years. GlaxoSmithKline supported education through contributions over $700, 000 ; , in-kind donations, and volunteerism supporting the NC Business Committee for Education, various education foundations, and the Governor's Entrepreneurial Schools Award. PlayMaker's Repertory Company's educational matinee series brings the arts into the classroom. GlaxoSmithKline provided $15, 000. Habitat for Humanity received $75, 000 toward construction of three homes for low-wealth families. GlaxoSmithKline employees volunteered to build these and other Habitat homes. GlaxoSmithKline's Investment in Volunteer Excellence GIVE ; provided $500 grants to qualifying non-profit organisations based on employee partner volunteer time. GIVE grants totalled $349, 000 and GlaxoSmithKline employees volunteered over 100, 000 hours. Finally, the North Carolina GlaxoSmithKline Foundation for the Advancement of Education, Science and Health is an endowed, self-funding organisation which operates as a separate entity. The foundation publishes its own annual report, which is available on request, and uses its asset base to support maths, science and health education in North Carolina. International GlaxoSmithKline's International Community Partnerships projects addressed health education and mobilisation, providing partnership funding of 1 million in 2001. Programmes included: 369, 000 to support its PHASE initiative Personal Hygiene And Sanitation Education ; in Kenya, Uganda, Nicaragua and Peru. PHASE provides hygiene and sanitation education for school children with the aim of reducing diarrhoea-related disease and deaths. 140, 000 allocated to two health improvement programmes for indigenous population communities in Australia. 100, 000 provided to fund a new HIV AIDS clinic in the Masoyi tribal area of Mpumalanga, South Africa. The clinic is part of a three-year, 300, 000 GlaxoSmithKline programme to provide a quality continuum of care to all those in the region who are infected and affected by HIV AIDS. GlaxoSmithKline's Rural Nursing Excellence programme in Thailand, which sponsors female high school graduates from rural areas to complete four year nursing degrees. GlaxoSmithKline has donated 500, 000 over five years to train 200 nurses, and March 2001 saw the first graduates of the programme.
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December 13, 2005 Jan-Thies H. Van Asseldonk Demyelination, degeneration, and deficit in multifocal motor neuropathy and chronic inflammatory demyelinating polyneuropathy J.H.J. Wokke, L.H. Van den Berg, H. Franssen supervisors Multifocal motor neuropathy MMN ; and chronic inflammatory demyelinating polyneuropathy CIDP ; are disorders of the peripheral nervous system that are poorly understood, difficult to diagnose and treatable with immune modulating drugs. Jan-Thies Van Asseldonk was able to improve the understanding of the mechanisms underlying deficit in MMN and CIDP and to derive better neurophysiological criteria for the diagnosis of MMN and CIDP. These findings may improve identification of patients with these treatable neuropathies.
Do not exist then a trial of a reflux therapy may be the best that the clinician can offer. Barium radiography of the upper GI tract had traditionally been used to diagnose GER. However, with the advent of esophageal pH monitoring which looks at esophageal dynamics over a much longer period, it has become clear that barium radiography is unreliable and may give totally misleading results lO ; . In our own experience of 44 patients with no demonstrable radiological reflux, 18 41% ; patients showed severe GER on subsequent esophageal pH monitoring with only 13 29.5% ; showing no significant GER Table III ; . Only 14 8.3% ; patients out of 29 who demonstrated radiological reflux showed severe GER on pH monitoring while 7 24.1% ; showed no significant reflux Table IV ; . Although barium radiography is use306 and levothroid, for example, flolan.
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2 , 3 , 4 importantly, the british national formulary 2 specifically highlights that `rifampicin is such a potent enzyme-inducing drug that even if a course lasts for less than 7 days the additional contraceptive precautions should be continued for at least 4 weeks after stopping it and levoxyl.
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Printer-friendly format email to a friend last editorial review: 3 10 2003 medicinenet provides reliable doctor produced health and medical information.
What keeps me from fighting falls and fractures everyday? How can I reach my goals to fight falls and fractures everyday? To help fight falls and fractures everyday: Remember the health benefits of fighting falls and fractures Ask for support from my family, friends, and doctor Think of easy ways to find time for my new habits If I sometimes forget, just be positive and try again and loestrin!
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Questran Sach 9g 4g Of Ingredient ; Questran Light Sach 9g 4g Of Ingredient Ispag Husk Gran Eff G F S Fybozest Gran Eff G F S Colestipol HCl Gran Sach 0.2% 5g Colestipol HCl Pdr Sach 0.2% 5g Colestid Gran Sach 0.2% 5g Colestid Orange Pdr Sach 0.2% 5g Fluvastatin Sod Cap 20mg Fluvastatin Sod Cap 40mg Fluvastatin Sod Tab 80mg M R Lesc0l Cap 20mg Elscol Cap 40mg Lecol XL Tab 80mg Fenofibrate Cap 200mg Micronised ; Fenofibrate Cap 67mg Micronised ; Fenofibrate Cap 267mg Micronised ; Fenofibrate Tab 160mg Micronised ; Lipantil Micro 200 Cap 200mg Lipantil Micro 67 Cap 67mg Lipantil Micro 267 Cap 267mg Supralip 160 Tab 160mg Gemfibrozil Cap 300mg Gemfibrozil Tab 600mg Lopid 600 Tab 600mg Nicotinic Acid Tab 50mg Maxepa Liq Maxepa Cap 1g Pravastatin Sod Tab 10mg Pravastatin Sod Tab 20mg Pravastatin Sod Tab 40mg Lipostat Tab 10mg Lipostat Tab 20mg Lipostat Tab 40mg Simvastatin Tab 10mg Simvastatin Tab 20mg.
The elaborated conditions were shown as a good ones for quantitative determination of compounds of this group by gas chromatographic method present in substances and pharmaceuticals and lotensin.
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Additional reactivations are common.16, 19, 20 The peak viral loads were very similar each time supporting the belief that repeated antiviral therapy courses were similarly efficacious. Most patients who developed CMV disease had, therefore, already been treated pre-emptively at least once and developed CMV disease during a second or later reactivation supporting previous data that CMV-specific immunity is a key factor in the control of CMV21-25 and that antiviral therapy is only a temporary measure until specific immunity has developed. A very interesting finding was that the quality of the response to antiviral therapy differed between patients who did or did not develop CMV disease. A slow response seemed to predispose to later development of CMV disease and was an independent risk factor when controlled for acute GVHD. This could be of practical importance since it is possible that such patients would benefit from prolonged antiviral therapy. We used different antiviral drugs for pre-emptive therapy and all seemed to have similar efficacy. Thus, the likelihood of a repeated reactivation did not seem to depend on the drug used.16 It should be recognized that the overall risk for CMV disease in this study was low and the mortality in CMV disease was only 2%. We were unable to find the high frequency of late CMV disease seen in other studies.21 Why there are such differences between centers is unknown. The selection of patients undergoing transplants is most likely one reason since using more mismatched donors is a risk for the development of severe acute and chronic GVHD. However, other factors such as use of antiviral therapy and GVHD prophylaxis and therapy might also be of importance. The risk factors for CMV disease that we did identify are not surprising. The correlation between CMV disease and acute GVHD has been known for a long time.26 The use of corticosteroids is also a risk factor for CMV disease.7, 27 That a CMV seronegative donor for a CMV seropositive patient is a risk factor for CMV disease has not been shown before.28 However, it has been shown that this serological combination.
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| Lescol without prescriptionSector OTC Healthcare Unit % Retail value rsp 2000 rank ; 2001 rank ; 2.73 9 ; 2002 rank ; 2.46 9 ; 2003 rank ; 2.56 10 ; 2004 rank ; 2.55 13 and lysergic and lescol, for instance, lescol 40.
Yes, it' s safer than statins - popular ones are lipitor, zocor, pravachol, lescol, advicor, crestor and mevaco - newsday warning over grapefruit juice and cholesterol pills may 10, 2006 the grapefruit hazard is not significant for other statins, such as novartis ag' s lescol, bristol-myers squibb co' s pravachol and astrazeneca plc' s cresto - daily mail - uk statin alternatives may 8, 2006 currently, six statins are approved by the fda: atorvastatin lipitor ; , fluvastatin lescol ; , lovastatin mevacor ; , pravastatin pravachol.
Some of these agents can be given in combination with an antiandrogen, which is a drug that blocks the action of male hormones and macrobid.
| And glucokinase see reviews by McClenaghan & Flatt, 1999a, b ; . Primary characterization of clonal rat BRIN cells revealed expression of GLUT2 in membranes from BRINBG5, BRIN-BG7 and BRIN-BD11 cells. Notably, the two enzymes responsible for glucose phosphorylating activity, glucokinase and hexokinase, were also detected in the hybrid BRIN cells. Effective -cell glucose-sensing comes from a high glucokinase: hexokinase ratio and, while glucokinase only contributes around 5% to the total glucose phosphorylating activity in RINm5F cells, this was much higher in each of the three BRIN cell clones. With the highest GLUT2 protein expression and a high glucokinase: hexokinase ratio, the BRIN-BD11 cells showed the most impressive glucose-sensing ability McClenaghan et al. 1996a ; , which translated into a stepwise increase in insulin release in response to 4.2 16.7 mm glucose P 0.01 to P 0.001 ; . While most insulin-secreting cell lines are either unresponsive, as in the case of parental RINm5F cells, or respond to subphysiological glucose concentrations, the threshold for glucose-stimulated insulin release in BRIN-BD11 cells is as reported in normal -cells, and these cells demonstrate a strong first phase insulin release with sustained release at a level marginally higher than basal, corresponding to the second phase McClenaghan et al. 1996a ; . The importance of glucokinase: hexokinase ratio to effective glucose-sensing is illustrated by the features of BRINBD11 cells McClenaghan et al. 1996a, 1998b ; and through establishment of glucose-stimulated insulin release in RINm5F cells by overexpression of glucokinase Tiedge et al. 2000.
No gentleman to keep you warm at nights?" Slay asked. "No." She was happy her word was the truth. Even though he asked her with nonchalance she knew Slay had a greater interest. They had a weird relationship like that he couldn't stand the thought of her that way, his sister with some man. It was just another reason why she worked so hard at distancing herself from him. Why she kept the few men she encountered at arms length. "So, " he said, "you think you can hook me up, bring out the white boy in me?" Cydney sighed. "I'll try." * Cydney sat in the chair across from her couch watching the rise and fall of her brother's chest. She couldn't bring herself to close her own eyes. Not with him here. Her feelings for Shammond were an unhealthy mix of contempt and love. To the outsider, the two emotions seemed implausible, but to Cydney they made perfect sense. Her brother, after all, was two very different people: Shammond and Slay. Shammond was a protector, a provider, a giver. Slay was a destroyer, a neglector, a taker. As Cydney continued to watch him sleep, his baggy jeans hanging below his waist and showing off his boxers, a copy of Essence magazine about to fall from his fingers onto the carpet, Cydney wondered which of the two, Shammond or Slay, was stronger. The phone rang and interrupted Cydney thoughts. She glanced at the time stamp on her digital cable box. It was well past midnight. She knew without checking the caller ID where the call originated from. She eased to her feet and tiptoed across the carpet to.
VA R I Bauchner H. 1997. Parents' impact on antibiotic use. APUA Newsletter. 1997: 15 1 ; : 1-3. Available at: : healthsci.tufts apua Newsletter 15 2a Accessed September 20, 2001. 33 Nyquist A-C, Gonzales R, Steiner JF, Sande MA. Antibiotic prescribing for children with colds, upper respiratory tract infections, and bronchitis. Journal of the American Medical Association 1998; 279: 875-877. Napoli M. Children and antibiotics: cutting back on inappropriate prescriptions. HealthFacts [serial online]. March, 1999. Available at: : findarticles cf 0 m0815 1999 March 54753532 print.jhtml Accessed September 20, 2001.
Dean Health Plan Formulary cont' Therapeutic Interchange List Note: Suggested interchange is product appropriate for MOST indications. Last Updated * 7 5 2007 Non-Preferred Not Covered Alternative * PCE erythromycin pemoline amphetamine dextroamp methylphenidate PENETREX ciprofloxacin smx-tmp PENLAC clotrimazole betamethasone cr econazole cr LAMISIL LOPROX GEL PENTASA ASACOL PERCOCET 2.5 325, 7.5 ; oxycodone acetaminophen PERIOSTAT doxycycline 100mg PEXEVA citalopram paroxetine phentermine Plan Exclusion POLYCITRA sodium citrate and citric acid soln PONDIMIN Plan Exclusion PONSTEL diclofenac ibuprofen naproxen PRANDIN glipizide glyburide PRAVACHOL CRESTOR LESCOL LESCOL XL lovastatin simvastatin VYTORIN PRECISION QID METERS & STRIPS ACCU-CHEK METER ACCU-CHEK TEST STRIPS FREESTYLE FLASH METER FREESTYLE TEST STRIPS PRECISION TEST STRIPS PRECISION XTRA METER PREVACID CAP ACIPHEX PRILOSEC OTC PROTONIX PREVPAC ACIPHEX PRILOSEC OTC PROTONIX PRILOSEC ACIPHEX PRILOSEC OTC PROTONIX PROAMATINE fludrocortisone PROCARDIA XL amlodipine nifedipine ER promethazine DM OTC Alternatives PROPECIA Plan Exclusion PROQUIN XR ciprofloxacin.
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