Drugs 64 , 1339– 1358 2004.
An art and a science For many decades, naming a drug was considerably less complex than today. With fewer drugs on the market, trademark classes were less crowded and there was greater opportunity for `newness' in a name. However, to a great extent, what arose was a proliferation of names of a certain `type'. As the GP and prescribing audience were the core focus of pharma companies' naming efforts, brand monikers became predictable, with many brands in a given category sounding like everyone else. Names spoke largely to the science - referencing the generic and or to the specificity of a drug's indication, for example, rebetol schering.
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Establishment of the Office was lauded as effective in putting the FDA "at the forefront of recent advances in the industry."179 Having served its purpose of equipping the agency with the ability to effectively regulate biotechnology, the Office of Biotechnology was abolished in 1994.180 The FDA also took steps to enhance its science base in preparation for technology based on artificial intelligence. Scientists at CDRH began studying artificial intelligence and preparing for review long before they were presented with any applications. Neural networks, which use biological systems to process information, are now being used to create "smart" devices such as automatic Pap smear readers to do repetitive pattern recognition analysis. As one FDA official explains, "Our scientists saw that the use of artificial intelligence in medical devices was on the horizon and that we needed to have expertise in the area. As a result of our investment in this area, when the first application came in the door, we were ready for it."181 In the late 1990's and early 2000's, the FDA was faced with a wave of advanced biotechnology products. Breakthroughs in genomics, proteomics, gene therapy, and tissue engineering resulted in a significant increase in applications for clinical testing of novel technologies. In attempting to keep pace with the explosion of new technologies, the FDA has initiated several policies to improve the agency's effectiveness. First, former FDA Commissioner Jane Henney promulgated several initiatives to improve the quality of the FDA workforce. She contracted with an outside group to work with the scientific staff and the office of human resources to determine the necessary composition of the scientific workforce in the near future.182 The contractor was also directed to investigate ways to improve recruitment and retention at the agency. As a result, FDA attrition rates have decreased slightly in recent years.183 Second, the FDA has made efforts to improve internal training. For example, the centers put on monthly training sessions; the agency has established an alumni program to keep former.
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PROVENTIL HFA . PROVENTIL SOLUTION . PROVERA . PROVIGIL . PROZAC . PROZAC WEEKLY . PSORCON . PULMICORT . PULMICORT RESPULES * . PULMOZYME * . pyrazinamide . PYRIDIUM . pyridostigmine .3 4 quazepam .4 QUESTRAN .1 9 quinapril .1 9 quinapril hydrochlorothiazide .1 9 quinidine gluconate ext-rel.1 9 quinidine sulfate .2 0 quinidine sulfate ext-rel.2 0 QUIXIN.2 7 QVAR .4 6 RANEXA .2 0 RANICLOR .1 0 ranitidine . RAPAMUNE * . RAPTIVA . RAVI . REBETOL CAPSULES . REBETOL ORAL SLN . REBIF . REGLAN.
If, for one reason or another, the public always ends up using the version of the medicine which incorporates the latest derivative invention, then the patent holder will, in effect, be able to prolong the monopoly for as long as the patent office keeps granting patents. But there is no international obligation under the TRIPS Agreement, or any other global agreement, to accept and grant patents for all these additional inventions[10] and ribavirin.
Table 3. GenTakTM Adhesive Measurements on Final Mounted 6" Composite of the Product Wafer and Carrier.
It is my great pleasure to attend the final session of the round-table meeting on law development and socio-economic change in asia ii ; and also to give closing remarks for this meaningful meeting and requip, because side effect.
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1. Wasser Pain Management Centre, Toronto, ON; 2. Hamilton, ON; 3. Brookdale Research, Peterborough, ON; 4. CHUS-Hpital Fleurimont, Sherbrooke, QC; 5. London East Medical Centre.
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With respect to high-pressure related OAG, characteristic histopathologic features have been described leading to atrophy even in the absence of cupping. Diffuse and centrally intense hydropic axonal degeneration and central blocked retrograde axoplasmic transport explain loss of central acuity, generalized contraction of visual field, and generalized optic atrophy without glaucomatous cupping in eyes with prolonged highpressure secondary glaucoma.4 Recent research has found genetic factorial influences in progressive normal-pressure or normal-tension open angle glaucoma NTG ; . Examples include the optic atrophy 1 gene OPA1 ; IVS 8 + 32 polymorphism, which has been associated with secondary glaucomatous optic atrophy in NTG and may be used as a marker for this disease association.5 This polymorphism also influences the phenotypic feature in patients with high tension glaucoma HTG ; and should be considered a genetic risk factor not only for NTG, but also for HTG.5 Individuals with an E50K mutation in the optineurin gene OPTN ; were found to have NTG that appeared to be more severe than in a control group of subjects with NTG without this mutation.6 A mutation of the GLC1A gene has also been implicated in the formation of NTG and HTG.7 Systemic cardio-vascular disease, circulatory insufficiency, ischemia, diabetes, and hypertension are examples that can have a direct affect on optic nerve function and possibly propagate glaucomatous progression to optic atrophy. Generalized inflammatory or auto-immune conditions can be a contributor to end stage disease as can systemic metabolic disorders. Orbital retro-bulbar compressive optic neuropathies will also predispose the eye to GOA. Examples include conditions such as carotid stenosis leading to non-arteritic ischemic optic neuropathy NAION ; which will pre-dispose the optic disc to secondary glaucomatous optic atrophy. Giant cell arteritis GCA ; with associated temporal arteritis TA ; can create pathology producing arteritic ischemic optic neuropathy AION ; which will likewise only initiate or enhance progression. Elevated blood-serum levels of C-reactive protein CRP ; , an inflammatory marker linked with atherosclerotic vascular disease, may also be a sign of ocular ischemia potentially advancing the disease.8 Metabolic syndrome and insulin resistance have been associated with diurnal variations in IOP which may have an implication in allowing progression to glaucomatous optic atrophy.9, 10 Advanced orbital thyroid disease leading to Grave's ophthalmopathy with retro-bulbar compressive optic neuropathy is an example which can mechanically allow for glaucomatous progression as well. Unfortunately, there is no treatment to reverse the effects of secondary end-stage glaucomatous optic atrophy. In its most advanced state, visual acuity and visual field loss can decline to a no-light-perception NLP ; level. Aggressive ocular and systemic treatments are preventative measures and must be instituted in high-risk individuals before atrophic progression. Preventative therapy includes topical ocular hypotensive medications providing for maximum lowering of IOP. Target pressures must be set significantly lower at the onset of treatment to provide optimal protection. In high risk individuals, at least 30% - 35% reductions with IOP's consistently 12mm Hg is not an unreasonable goal to attain. 8.
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Pegylated Interferon Pegylated interferon is a long-acting formulation of interferon that can be injected less often once a week. Pegylation is a process in which polyethylene glycol the PEG molecule ; is attached to a protein. This creates a shield around the interferon which helps to protect it and also delays the clearance of interferon from the body. Since the PEG module allows interferon to stay in the body longer there is greater suppression of the hepatitis C virus. The are currently two FDA approved pegylated interferons Schering-Plough's Peg-Intron was approved in August 2001; and Roche's Pegasys was approved in October 2002. Ribavirin Ribavirin brand name Rebetol, produced by Schering-Plough; Copegus, produced by Roche Pharmaceuticals; or brand name Ribasphere, produced by Three Rivers Pharmaceuticals ; is a nucleoside analog also called a nucleoside reverse transcriptase inhibitor, or NRTI ; antiviral drug. It is taken orally by mouth ; twice a day. The exact way ribavirin works is unknown. However, it is believed that when ribavirin enters a cell it is phosphorylated; it then acts as an inhibitor of.
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Definition: A future view containing one or more health characteristics which describe conditions which the patient client has not yet got but may do so in the future without some action As health care begins to focus more and more on prevention the use of this heading is likely to rise. Primary care staff may wish to screen for ischaemic heart disease by identifying high risk groups. These patients may have a record entry At Risk Ischaemic Heart Disease, for example, side affects.
Outpatient Prescription Drug Calendar Year Maximum Some pharmacy benefit plans have a maximum dollar amount allowed per calendar year. The following chart lists medications that are available through the pharmacy benefit and do not apply to the outpatient prescription drug calendar year maximum. Medications That Do Not Apply to the Outpatient Prescription Drug Calendar Year Maximum Adalimumab Humira ; * Interferon Gamma-1B Actimmune ; Anakinra Kineret ; * Etanercept Enbrel ; * Dornase Alfa Pulmozyme ; Glatiramer Copaxone ; Interferon Alfa-2B Intron A ; Interferon Alfacon-1 Infergen ; Interferon Beta-1A Avonex, Rebif ; Interferon Beta-1B Betaseron ; Interferon Ribavirin Rebetron ; Oral Chemotherapeutic Agents Oral Immunosuppressants Peginterferon Alfa-2A Pegasys ; Peginterferon Alfa-2B Peg-Intron ; Ribavirin Copegus, Reetol ; Tobramycin 2% Ampules Tobi ; Teripataride Forteo and rifater.
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Strongly positive in most cases, not all studies have shown a favorable effect. The BEST study Beta-Blocker Evaluation of Survival Trial ; , in which bucindolol was given to patients with advanced heart failure, demonstrated only insignificant effects on mortality.17 The reason for the discrepancy between the results of the BEST trial and the positive results of other trials is not known with certainty, but differences in the pharmacologic profile of bucindolol and the drugs used in the other successful trials is a much more likely explanation than differences in the patient populations that were studied and rifampin.
Local Area Health Board can usually provide a scabies control protocol. Co-ordinated treatment is essential if patients belong to different general practitioners. Treat all infectious patients with stringent isolation procedures until cured. Multiple treatments may be necessary and consider adjunctive oral treatment such as ivermectin. Treatment of the entire body may be necessary including the head. Patients with Norwegian scabies will need exfoliation creams e.g. salicylic acid 6% cream ; , and consultation with a dermatologist is recommended. All significant contacts should be evaluated with careful and, if appropriate, a full body examination. Scabies in affected staff, patients and contacts can look atypical. If possible the diagnosis should always be confirmed with microscopic scrapings or identification of typical burrows. Treat all affected contacts simultaneously. Nursing staff or attending carers should wear plastic disposable gloves and practise strict barrier nursing. They should be careful about excessive shaking of bedding and clothing that may disperse infected scale and debris widely into the environment. An acaricidal spray e.g. benzyl benzoate ; will help to decontaminate rooms with application of the spray to bedding, chairs, floors, pillows. Fumigation and closure of the area are other options. Shoes should be placed in a plastic bag for two weeks. Clothing and sheeting should be washed in hot water and ironed or put through a hot dryer. Storage for two weeks may be necessary for items that cannot be decontaminated. Follow-up with weekly treatments to highly infected individuals is important. Repeat scrapings may be necessary to ensure that these patients are finally clear. Contacts must be followed up at 46 weeks. Ensure that staff, relatives and contacts are fully aware of the implications of scabies and are warned to be suspicious of persistent or recurrent itchy rashes for the next few months.
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For participants who do not receive any wages, the contributions are based on certain nominal amounts that will be determined periodically by the Government." Public pensions and life insurance will not be provided for people who cannot pay contributions. As these provisions are long-term perspectives yet will not cover all parts of the population, microinsurance could be an appropriate mechanism to complement the benefits mentioned in the law. Through the project Development of a Social Health Insurance System in Indonesia SHI ; , it is attempting to incorporate microinsurance as one instrument of other social security systems. If the Indonesian Government would accept this approach, a number of advantages are expected such as: Systematic development of microinsurance products through state-owned and private insurance providers; Enabling organizations of civil society to assist and or offer microinsurance services complying with the legal framework and help to ensure the viability of insurers; Creating a suitable regulatory environment e.g., allowing microinsurance activity and protecting consumers from misleading selling practicesthis is even more important because the client base is often uneducated and lacks the ability to assess the performance of the insurer Promoting formal-sector insurance institutions to enter the low-income market and adjust their delivery channels according to the requirements of low-income clients. Since the Social Health Insurance project contributes to defining the rules and regulations as well as the implementation structure of the Social Security Systems law, SHI can lobby for promoting microinsurance. These activities, however, are not part of the current PPP project. 4.7 Competition: Strengths and weaknesses Strengths and weaknesses of institutions currently offering microinsurance are noted here. The number of institutions offering microinsurance is very limited, except credit life insurance linked to the banking sector. Thus, the assessment covers only a few organizations and roxithromycin and rebetol, for example, cdc.
This guideline is based on an assessment of current scientific and clinical information. The expert consensus panel recognizes that specific patient care decisions may be at variance with this guideline and are the prerogative of the patient and the health professionals providing care, considering all of the circumstances involved. This guideline does not substitute for clinical judgment.
The foundation's charitable purpose is to grant financial assistance to pay expenses incurred by persons or their families who are suffering from serious, debilitating, or f-16 emisphere technologies, inc notes to the financial statements- continued ; prolonged illnesses and reboxetine.
By either medical or surgical oophorectomy can prove curative. It is generally agreed that there is no single biological substrate that can be considered causal in isolation, but a bio-psychosocial model probably best fits the clinical picture and should underpin approaches to treatment.
Clone wereobtained by re-screening a fetal brain cDNA library Stratagene ; with probes derived from the genomic clone hp78a nucleotides 891-960 ; . Nucleotide sequence was obtained using Sequenase U. S. Molecular cloning has led tothe discovery of primary amino Biochemical Cow. ; , Bst DNA polymerase Bio-Rad ; , or TaqTrack seacid sequences and pharmacological properties of five adenyl- quencing kit Promega Corp., Madison, WI ; . Expression-The entire coding region of hp78a 1338 bp ; , including a t e cyclase inhibitory 5-HT1' receptors l ; , three 5-HTz receptors 2 ; all coupled to phosphoinositide hydrolysis, one 5-HT3 27 bp of 5'-untranslated and 50 bp of 3'-untranslated sequence, was cloned into the Sal1and EcoRI sites of the polylinker-modifiedeukaryreceptor 3 ; shown to be a ligand-gated ion channel, and two otic expression vector pcEXV-3 19, called EXJ.HR.2 Monkey kidney "5-HT5" receptors 4, 5 ; with unknown signaling properties. cells cos-7 ; were grown and transiently transfected with pcEXV-3series is the hp78aFL recombinant expression vector Notably absent from the cloned serotonin receptor using DEAE-dextran reagents 5-HT4 receptor, which has been shown to activate adenylate obtained from Specialty Media, Lavellette, NJ ; as described 14 ; . Tissue Localization Studies-Human tissues National Disease Recyclase 6, 7 ; . Recently, the cloning of a novel serotonin receptor 5-HTs ; positively coupled to adenylate cyclase has been re- search Institute ; werehomogenized and total RNA extracted using guanidine isothiocyanate CsCl NA was prepared from 0.5pg of total ported 8 ; . RNAwith random hexanucleotide primers 500pmol ; using Superscript We report here the cloning of a second 5-HT receptor that reverse transcriptase Life Technologies, Inc. ; in 50 m~ Tris-HC1 pH couples t o the stimulation of adenylate cyclase activity. The 8.3 ; buffer containing 40 units of RNasin, 2.5 m~ MgC12, 50 m~ KC], and 1m~ dNTPs, at 42 "C for 1h. An aliquot of the first strand cDNA reaction mixture dNTP * This work was partially funded by Small Business Innovation Re- 0.1 pg ; was amplified in a 50-pI PCRofTaq polymerase 200 w buffer in the search Grant 2R44NS27789 and by Eli Lilly and Co. The costs of final concentration ; with 1.25 units publication of this article were defrayedin part by the payment of page supplied by the manufacturer Perkin-Elmer Cetus ; , and 1p~ primers and 5"GGTGGTGGCTcharges. This article must therefore be hereby marked "advertisement" 5'-GGAACAGATCAACTACGGCAGAGT-3' GC'M"l'CTGTTCTCGC?TAAA-3' ; . The following conditions were used in accordance with 18 U.S.C. Section 1734 solelyto indicate this fact. The nucleotide sequence s ; reportedin this paper hasbeen submitted in the PCR reactions: 2 min at 94 "C, 2 min at 68 "C, and 3 min at 72 "C the GenBankTMIEMBL Data Bank with accession number s ; L21195. with a 3-s extension for 30 cycles.A final cycle with a 10-min extension reaction at 72 "C was also performed. The PCR products were run on a $ To whom reprint requests should be addressed: Synaptic Pharrnaceutical Corp., 215 College Rd., Paramus, NJ 07652. Tel.: 201-261-1331; 1.5% agarose gel and subjected to Southern blot analysis with kinased Fax: 201-261-0623. oligonucleotide probe abbreviations used are: 5-HT, serotonin 5-hydroxytryptamine CTCCAGAAGGAGGTGGA-3' ; . TM, transmembrane; PCR, polymerase chain amplification; 5-CT, 5-carboxamidotryptamine; bp, base paids ; , 8-OH DPAT, 8-hydroxy-24di-nJ. A. Bard, unpublished data. propy1amino ; tetralin.
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4.1 National Prescribing Service The NPS is a member-based organisation providing evidence-based information and services to health professionals and the community on Quality Use of Medicines. To achieve this outcome there is a close collaborative relationship with the NPS and the pharmaceutical industry. 4.1.1 RADAR In response to demand from health professionals for timely access to information about new medicines, NPS launched RADAR Rational Assessment of Drugs and Research ; . RADAR is a program that provides prescribers with timely and independent information about new drugs as they come to the market or are listed on the PBS; or when research is published that significantly changes the way a drug is used or prescribed in primary care. A key element of RADAR is the inclusion of the reasoning behind why a medicine has a particular PBS listing, based on PBAC deliberations. To perform this activity, NPS representatives regularly attend PBAC meetings as observers with the aim to be better informed about the process and the reasoning for PBAC decisions. Medicines Australia, NPS and the Department of Health and Ageing have collaboratively agreed to the process and identified documents submitted as commercial-in-confidence that may be released. Agreement on the documentation that may be released from the sponsor ensures a consistent approach can be adopted by NPS in informing prescribers of PBAC decisions. 4.2 Medicines Australia Code of Conduct and ribavirin.
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Sources: canadian statistics obtained from research studies ramsey et al, 1999 ; , national health surveys miller, 1997; so, 1997; and blais et al, 1997 ; published findings from the national population health survey, quebec health survey, and quebec health insurance board ; , public opinion polls 1997 public opinion poll by angus reid group, 1997 survey by canada health monitor, and a 1999 survey by the berger monitor ; , and focus groups the office of natural health products, health protection branch commissioned a focus group by the angus reid group.
Information Regarding Patient Eli Lilly and Company Lilly Cares Lilly Cares Program Administrator Eli Lilly and Company P.O. Box 25768 Alexandria, Virginia 22313 800 ; 545-6962 Patients must be US residents. Eligibility is determined on a case-by-case basis. Eligibility is based on the patient's inability to pay and lack of third-party drug payment assistance, including insurance, Medicaid, government-subsidized clinics, and other government, community, or private programs. Medications are provided directly to the physician. Quantity of supply is dependent upon type of product being prescribed. Forms to qualify will be provided to the physician. The physician is requested to provide prescription information, including signature and DEA number on the form, and to confirm the patient's ineligibility for other forms of outpatient drug coverage. The patient is requested to provide pertinent information and state financial need. Bristol-Meyers Squibb, Co. Patient Assistance Program Bristol-Meyers Squibb Patient Assistance Program P.O. Box 4500 Princeton, New Jersey 08543-4500 Mailcode P25-31 800 ; 332-2056 This program is designed to provide temporary assistance to patients with a financial hardship who are not eligible for prescription drug coverage through Medicaid or any other public or private health program. Physicians and other health care professionals who are interested in enrolling a patient should call the toll-free number above to request an application form.
AWARD Bronze URL : panaceapharma ENTRY TITLE Panacea Pharmaceuticals, Inc. CLASS Miscellaneous Professional CATEGORY Web Site DIVISION AUDIENCE.
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