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Last week, the first fda-approved weight-loss drug, alli , once sold by prescription as xencal , hit store shelves.
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Harmful effects of xenical Table 5 Multivariate hazard ratios 95% CI ; and p-values for three major outcomes by baseline levels of fibrinogen, plasma viscosity, blood viscosity, haematocrit, and white cell count, adjusted for a hierarchy of baseline covariates. Firstly for age and treatment group; subsequently for smoking; lipids HDL, LDL and VLDL cholesterol; log triglyceride other risk factors; and CHD indicators; as defined in the methods section. It is felt that drug therapy may be appropriate when reducing fat intake and increasing activity have failed to achieve improvement in the metabolic risk factors. Orlistat, a lipase inhibitor known as Xenjcal can be recommended. It is the only one of its type available in Australia. Orlistat or Enical will induce severe fat malabsorption. If a person has a high fat meal, then this will induce significant fatty diarrhoea and even faecal incontinence. This can be valuable retraining for the person. Very low kilojoule or low energy diets are useful in special circumstances where sufficient weight loss cannot be achieved and exercise is limited. An example of this is Modifast. It is a complete replacement meal of 1800 KJ or 425 calories per day including 56 grams of protein. It is only prescribed through a doctor. Modifast works well under a Dietitian's supervision but is considered a last resort. Low kilojoule vegetables and some fruit may be combined with the Modifast. It is low in fibre so the addition of pysllium husks or bran can be very helpful in preventing constipation and increasing satieity. Sometimes assistance with weight loss through fat malabsorption or a low energy replacement meal will give sufficient weight loss to allow more. Categories ativan bactrim bromazepam buspirone carisoprodol celebrex citalopram clonazepam depakote diazepam dormicum effexor fludrocortisone flurazepam hydroxyzine imovane lasix levothyroxine lexotanil lipitor lorazepam meridia midazolam modafinil fda rx free naltrexone paxil phenergan propecia proscar provigil prozac risperdal rivotril sibutramine sildefil soma strattera tamiflu tegretol tramadol trazodone tryptanol valtrex viagra xenical zoloft zolpidem zyprexa zyrtec online ordering glucotrol get without no required ; prescriptions.

Xenical and phentermine Subjects, dose, and route of adminisfration. Four mature, healthy male Rhesus monkeys were used in, for example, adipex phentermine xenical. Xenical how much does it cost The side effect profile of Qnexa was favorable, with the most common adverse event being mild and transient paresthesia. This is a known side effect associated with topiramate. In most incidences, paresthesia was observed at the time of dosing and during the first month of treatment. Paresthesia involves a tingling sensation in the extremities including the finger tips, toes, ear lobes and the tip the nose. Paresthesia was reported in 38% of Qnexa patients, compared to 22% for topiramate, 4% for phentermine and 2% for placebo. Clinical data in the Topamax label states that use of topiramate for the treatment of epilepsy was associated with paresthesia in 13% and 25% of patients dosed at 50 mg and 400 mg daily, respectively. In the Phase II trial no patients discontinued Qnexa therapy due to paresthesia, though one patient in the topiramate group did. The drop-out rate for Qnexa was 8% 4 pts. ; compared to 38% 19 pts. ; for placebo, 24% 12 pts. ; for phentermine and 14% 7 pts. ; for topiramate. One patient in the Phase II trial was not able to stay on maximum dose of the combination therapy, due to tolerance issues, after being titrated to it. The patient completed the trial at a lower dose, which was well tolerated. Vivus participated in a Qnexa End of Phase II meeting with the FDA during 2Q07 to finalize plans for Phase III trials which are expected to begin in the fall of 2007. The pivotal program will consist of two trials that will enroll a total of approximately 4, 500 patients who will be treated with Qnexa or placebo for 52 weeks following a four week titration period. The primary endpoint for the pivotal studies will be the number of patients who lose at least 5% of their body weight. Secondary endpoints will include the absolute placebo-adjusted weight loss, the number of patients who lose at least 10% of their body weight and the percentage reduction in waistline. In addition to the weight loss benefits seen with Qnexa, Vivus has presented observational data demonstrating that the drug provides improvements in glycemic parameters, reducing HbA1c from a baseline level of 7.7% to 6.5%., as well as in lipid and triglyceride profiles, and blood pressure. In June, Vivus initiated a Phase II trial of Qnexa in overweight and obese patients BMI 27kg m2 - 42kg m2 ; with type II diabetes. The randomized, placebo controlled, double-blind trial will enroll 180 patients who will receive therapy for 28 weeks. The dose and dosing regimen used in the previous Phase II study will again be used in this trial. The primary endpoint for the trial is a reduction in HgBA1c and secondary endpoints include changes in blood pressure and lipid parameters, absolute weight loss, percent of baseline body weight lost and change in waist circumference. Enrollment into the trial is expected to be completed in 3Q07 and results from the trial could be released in mid-2008. Topiramate is currently approved for the treatment of epilepsy and migraines. The drug is marketed under the brand name Topamax by Johnson & Johnson JNJ, Not Rated ; . JNJ had conducted Phase III trials with topiramate for the treatment of obesity. The trials showed the drug was efficacious at the higher doses with weight loss continuing through one year and it has been suggested that the drug acts by increasing satiety through a GABA-ergic mechanism. However, the poor side effect profile of the drug led JNJ to suspend further development. Topamax is administered as a monotherapy for the treatment of epilepsy at a dose of 400mg per day, and for the treatment of migraine at a dose of 100mg per day. The amount of topiramate in Topamax is less than the doses at which it was shown to be effective in the obesity trials. Vivus has stated that the amount of topiramate used in Qnexa is also below these effective doses. Topiramate's composition patent will expire by 2009. Phentermine is a member of the anorectic class of drugs that is known to have appetite-suppressing activity. This drug is available as a generic and is used in the treatment of obesity. Phentermine and fenfluramine were the active ingredients of fen-phen, the anti-obesity drug that was withdrawn from the market due to cardiovascular and pulmonary adverse events. Importantly, these adverse events were attributed to fenfluramine, which was also removed from the market, and not to phentermine. To date Qnexa has shown the most potent efficacy of drugs approved or in late stage development for the treatment of obesity. Although this efficacy was demonstrated in a single center study, the weight loss demonstrated was more than double that seen with Meridia, Xenicap or rimonabant and the weight loss was achieved in half the amount of time 24 weeks vs. 52 weeks ; . If the efficacy demonstrated in Phase II can be shown in a larger, longer duration Phase III program, and the safety profile remains favorable, it is our view that Qnexa would have a highly competitive profile in the anti-obesity market. We believe that Qnexa will likely serve as the benchmark for efficacy among anti-obesity drugs; in addition, the dropout rate in patients on Qnexa was favorable given the high rates normally seen in obesity trials. Lorcaserin Lorcaserin is currently being developed by Arena Pharmaceuticals ARNA, Not Rated ; in obesity. The drug is a selective serotonin 2c receptor agonist which targets the hypothalamus, a region of the brain known to impact satiety the feeling of fullness ; . Lorcaserin is in Phase III studies, the first of which was initiated in September, 2006. The Phase III program, named BLOOM Behavioral Modification and Lorcaserin for Overweight and Obesity Management ; , for lorcaserin involves three trials that will enroll a total of 6, 000 patients. The first of three Phase III trials in the BLOOM program completed enrolling 3, 182 patients in February and a Data Safety Monitoring Board is slated to review in 3Q07. The side effects seen with xenical are related to the reduced absorption of fat from your diet.

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