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Divis is quintessential pharma outsourcing company with 30% of its sales coming from custom synthesis area, expected to go up 50% in the next two years. The other significant contributor to revenue- generic API will grow relatively slowly. The high profile IPO and the run up since then, has stretched valuations. The longer-term story is strong, especially post 2005, when innovator companies are likely to look at R&D sourcing in a big way. Divi's Laboratories Limited's main areas of operation are generic APIs & Intermediates 60% of FY03 sales ; and custom manufacturing drugs for innovator companies. The company envisages to maintain leadership in custom synthesis of API's and intermediates for healthcare industry and to develop generic API's for the late life cycle needs of the industry. Exports constituted a sizeable 91% of the turnover for FY03. The facilities are primarily engaged in the manufacture of Active Pharmaceutical Ingredients APIs ; & Intermediates for Generics, APIs and Advanced intermediates for discovery compounds Custom Synthesis ; for pharma giants, building blocks for Peptides and Nucleotides, Carotenoids and Chiral ligands The facilities operate under full cGMP guidelines, Unit-1 at Choutuppal was successfully inspected by US FDA during September 2000. The company's second manufacturing facility near Vishakaptnam commenced operations in March 2003. The Rs400mn facility is expected to reach its full capacity utilization in the next fiscal when, some of the new custom synthesis and generic products in the pipeline are commercialized.
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Reference Books: 1. 2. 3. Pharmaceutical Engineering by K. Sambamurthy , New Age International Pvt. Ltd., New Delhi 1998 Introduction to Chemical Engineering International Student Edition ; , By Walter L. Badger & Jullus T. Banthero, McGraw Hill Publications 29th Printing 1987 ; Unit Process in Pharmacy by David Ganderton, William Helnemann Medical Borks Ltd, London, 1968 Perry's Chemical Engg. Handbook, 7th Edition 1997 International Edition McGraw Hill, Author Robert H. Perry, Don W. Green. Elements of Mechanical and Electrical Technology, B.H. Deshmukh P.V. Mondke, Seventh Edition Aug'92, Nirali Prakashan Machine Drawing, By N.D. Bhat, 10th Edition, Published by Character Bork Stall, Tulsi Sadan, Anand; 1974 Elements of Heat Engines , By N.G. Pandya, C.S. Shah, Fifth Revised and Enlarged Edition 1966, Charotar book stall, Tulsi Sadan, Station Road, Anand W.Rly ; , India Industrial Instrumentation, Donald P. Eckman, Seventh Wiley Eastern, Reprint, 1983, Wiley Eastern Ltd, 4835 24, Ansari Road, Daryaganj, New Delhi 110 002, for example, zobirax prices.
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Ong-term estrogen administration to postmenopausal women has been shown to reduce the risk of developing cardiovascular disease1 and the risk for angiographically significant coronary artery stenosis.2 Estrogen administration improves endothelial function in conduit vessels such as the brachial artery3 and epicardial coronary arteries.4 However, effects of short-term and long-term estrogen administration on vasomotor responses of the coronary resistance vessels and on nutrient blood flow to the myocardium in women remain unexplored. Coronary endothelial function has been assessed by intracoronary infusion of acetylcholine before and after administration of estrogen in postmenopausal women referred for coronary angiography because of suspected coronary artery disease CAD ; .4 This technique is invasive and cannot be ethically justified in healthy women without symptoms of CAD. Therefore, relatively noninvasive techniques should be used and alesse and zovirax, because zovirax injection.
Biovail Canada ; has expanded its range of coronary heart disease drugs with the acquisition from Athpharma Ireland ; of marketing rights to four products, which will complement Biovail's Cardizem promoted as a treatment for hypertension. These newly acquired products are Bisochron antihypertensive, Isocron long-acting nitrate antianginal and cholesterol lowering drugs Hepacol I pravastatin and Hepacol II simvastatin. Biovail recorded 19% increased net income of $63.0 M on 23% increased turnover of $191.4 M for 1Q 2003. Slightly decreased sales of Cardizem were partly compensated by increased sales of Zoovirax and Teveten.
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Studies of functionally compromised mutants co-expressed with wild type receptors suggest that homodimerization perhaps plays a role in receptor biogenesis, ligand binding and receptor signaling 2, 3 ; . Mutant receptors of the 2 adrenergic 2AR ; , CCR5 and dopamine D2 receptors have exerted a dominant negative effect on wild type receptor cell surface expression 8-10 ; . In contrast, surface expression of a mutant 2AR could be rescued by co-expression of WT receptor 11 ; , and internalization of a -factor receptor that could not internalize was rescued by co-expression of wild type receptor 12 ; . Several studies suggest that dimerization may be important for G protein coupling. Wild type -factor receptor signaling is inhibited by co-expression of a signaling deficient receptor 12 ; , and it is possible to inhibit both 2AR activation and dimerization with a peptide derived from transmembrane domain 6 of the receptor 13 ; . A double cysteine M3 Muscarinic receptor that has lost the ability to form covalent dimers and multimers, displays approximately a 50 fold reduction in binding affinity compared to wild type and a greater than 10.000 fold reduction in agonist potency 14 ; , and recently mutations that abolish dimerization of the -factor 15 ; , CCR2 and CCR5 16 ; receptors have been shown to also decrease or abolish agonist induced signaling. Although it is well established that 7TM receptors form homodimers; we are still far from understanding the functional consequences of this process. Two types of experiments are currently of great interest; experiments directed at defining the receptor domains involved in oligomerization and studies examining the role of oligomerization for ligand binding and signaling. We speculated that the AT1 receptor could be a means to advance our understanding of how receptor dimerization and zyban.
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United Kingdom -- Thrombocytopenia is a wellrecognized rare adverse reaction with measles, mumps, rubella MMR ; vaccine which is listed in the product information. A recently published study conducted by the Public Health Laboratory Service has found the absolute risk of a child developing idiopathic thrombocytopenic purpura ITP ; within 6 weeks of the first dose of MMR to be 1 22, 300 cases with 2 out of every 3 cases being attributable to MMR 1 ; . The Committee for Safety of Medicines has recommended: Children who developed ITP within 6 weeks of the first dose of MMR or its compnenet vaccines should have their serological status evaluated before the second dose is due. If serology testing suggests that a child is not fully immune against measles, mumps and rubella then a second dose of MMR is recommended. The Public Health Laboratory Service are offering a free serological testing service for children developing ITP within 6 weeks of the first dose of MMR.
The values indicate the concentration of drug in micromolar ; required for 50`9 inhibition of volume regulation . Volume recovery was determined 5 min after the hypotonic shock . The values given were determined graphically as described in the text and represent the range of four experiments. $ Concentrations in micromolar ; required for 50% inhibition of calmodulin-activated phosphodiesterase . From Weiss and Levin 1978.
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Iv ; Joint Epilepsy Council JEC ; literature working party Chairman: Judy Cochrane, Epilepsy Association of Scotland, 48 Govan Road, Glasgow G51 1JL. Tel: 0141 427 4911. For the computerized patient information package see section 9.1 ; , contact Dr Jim Harris, Network Medical Services, Tel: 01293 534411.
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