02242518 02239146 02246896 ACTONEL - 5MG TAB ACTONEL - 30MG TAB ACTONEL - 35MG TAB ASACOL - 400MG TAB CREST GUM CARE - 4.54MG G DIDROCAL MACROBID - 100MG CAP risedronate sodium risedronate sodium risedronate sodium 5-aminosalicylic acid stannous fluoride etidronate disodium and calcium carbonate nitrofurantoin M05BA M05BA M05BA A07EC A01AA M05BB J01XE tablet tablet tablet tablet toothpaste tablet capsule expired not sold!
Awareness of conditions such as deep vein thrombosis, osteoporosis, uncontrolled diabetes, influenza and peripheral arterial disease in markets such as Germany, France and the United States. Some major campaigns took place in 2005, such as a direct-to-consumer campaign in the United States on the importance of compliance with medical recommendations related to a drug treatment. Although we market most of our products with our own sales forces, we have entered into and continue to form partnerships to co-promote co-market certain products in specific geographic areas. Major arrangements currently include an agreement with BMS for the cardiovascular drugs Aprovel and Plavix, P&G for the osteoporosis drug Ac6onel and Teva Pharmaceuticals for the multiple sclerosis drug Copaxone. More details on these alliances are provided below under "-- Alliances". Our human vaccines are sold and distributed through multiple channels, including physicians, pharmacies and distributors in the private sector, and governmental entities and Non-Governmental Organizations NGOs ; in the public and international donor markets, respectively. Alliances In 2005, we had three major alliances through which four of our top 15 products were marketed. The first, with Bristol-Myers Squibb, or BMS, governs the development and marketing of Plavix and Aprovel. The second, with Procter & Gamble Pharmaceuticals, or P&G, governs the development and commercialization of Actonel. The third is a marketing agreement with Teva Pharmaceuticals regarding Copaxone. The financial impact of our principal alliances on our financial condition or results of operations is significant and is described in detail under "Item 5. Operating and Financial Review and Prospects -- Overview -- Financial Presentation of Alliances". Bristol-Myers Squibb We market Aprovel and Plavix through a series of alliances with BMS. The alliance agreements include marketing and financial arrangements that vary depending on the country in which the products are marketed. There are three principal marketing arrangements that are used in the BMS alliance: Co-marketing: Each company markets the products independently under its own brand names. Exclusive Marketing: One company has the exclusive right to market the products. Co-promotion: The products are marketed through the alliance arrangements either by contractual arrangements or by separate entities ; under a single brand name.
There are antiresorptive drugs, and that includes most of the drugs that doctors use like fosamax, actonel, calcitonin and estrogen.
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To determine the effect of a progressive atypical, multidirectional jumping intervention program on BMD on bone turnover as measured by bone biomarkers. METHODS Subjects Over 250 women from a Southwestern metropolitan community responded to advertisements through area interest groups, posted notices, and physician referral. Women were invited to participate in the study if the following criteria were determined by a phone screening to be present: 1 ; no comorbidity, such as diagnosed diabetes, coronary heart disease, peripheral vascular disease, pulmonary or orthopedic dysfunctions that preclude jumping; 2 ; not currently taking alendronate Fosamax ; , tamoxifen, calcitonin Miacalcin ; , raloxifene Avista ; , glucocorticoids, residronate Actoenl 3 ; no current involvement in regular aerobic and or weight training exercise; 4 ; no reported history of osteoporotic fracture; 5 ; body mass index BMI ; between 21-31 kg m2; and 6 ; on hormone replacement therapy HRT ; if more than 5 years postmenopausal. There were 59 women who fulfilled the screening criteria and had BMD measured. They were accepted into the study if the BMD T-score was -1.5 SD at hip and lumbar spine and if their primary care physician cleared them to exercise. Fifty-three postmenopausal women were selected and randomly assigned to one of two groups, an experimental intervention group N 25 ; and a control group N 28 ; . Measurements Bone mineral density of the femoral neck Neck ; , total hip Total ; , and lumbar spine LS ; was assessed at months 0 and 12 for all participants. Urine and blood concentrations of the biomarkers of bone turnover were assessed at month 0, 6, and 12. The BMD and biomarker testing were performed in the mornings at the General Clinical Research Center GCRC ; in the Audie Murphy Veterans Administration Hospital. Osteoporosis is defined by BMD measurement as a T-score less than 2.5 SD below the normal mean for a young, healthy adult.28 Dual x-ray absorptiometry DXA ; of the lumbar spine and hip represents the `gold standard' for diagnosing osteoporosis and predicting related fracture risk.29 All BMD measurements were obtained by the same technician with the pencil beam DXA bone densitometer, QDR 1500 series Hologic, Inc, Waltham, Mass ; .The scan mode was adjusted for trunk thickness. Neck, total, and lumbar spine L1-L4 ; BMD were all measured. All measurements were obtained and analyzed using standard protocols provided by the manufacturer. The short-term in vivo precision of the BMD was determined on 27 subjects performed in duplicate on the same day. The precision of the lumbar spine was 0.009 gm cm2 CV 1.0% ; . The precision of the total hip was 0.007 gm cm2 CV 0.87% ; . The precision of the manufacturer's spine phantom was 0.0017gm cm2 CV 0.17% ; . Urine N-telopeptide NTX ; and serum bone specific alkaline phosphatase ALK PHOS ; reflect bone turnover. These markers represent a more sensitive indicator of bone resorption than DXA and can indicate bone turnover as early as 3 months from the beginning of a pharmaceutical interven48.
In studies of women with postmenopausal osteoporosis, actonel significantly reduced the risk of new vertebral fractures in just one year.
Most sources described FACT as another shot in the marketing wars between Merck and P&G. One expert said, "This is another example of a surrogate marker outcome study.The fracture rate was not different, but that's being ignored, and I don't think you can ignore that. There is no real difference in efficacy in the two. BMD is not enough; you need a fracture study." Some sources suggested the FACT results were due to P&G developing a too-low dose of Actonel. An expert said, "I don't think P&G got the dose right, and that's why it and acyclovir.
Actonel was also shown to reduce the frequency of wrist and hip fractures by 39.
The decrease in marketing, selling and administrative expenses was primarily due to lower sales force expenses resulting from the previously announced restructuring of the primary care sales organization that became effective in march 200 • advertising and product promotion spending decreased by 4% to $352 million in the second quarter of 2006 from $365 million in the same period in 2005, primarily driven by the divestiture of the and canadian consumer medicines business in 2005 and lower spending on mature brands, despite increased investments in growth drivers and new products including orencia and sprycel and adapalene, for example, prevacid.
Do not lie down immediately after you take actonel.
Do U.S. consumers believe that Canadian online pharmacies are more legitimate than other foreign pharmacies? They might, because many online pharmacies claim to be Canadian when they actually operate out of other countries. Of the imported drugs seized by the FDA from 3 large airports in the U.S. in 2005, 85% of those labeled as originating in Canada were actually from 27 other countries. Many of the "Canadian" labeled products were found to be counterfeit, including Lipitor, Crestor, Zetia, Actonel, Nexium, Celebrex, and Propecia. The FDA has identified Mediplan Prescription Plus Pharmacy and Medi-plan Global Health as operators of bogus Canadian websites a list of some of the websites is available at the FDA link below ; . Tell patients that many websites operated from countries other than the U.S., including Canada, provide unapproved drugs from unreliable sources. The drugs may not be effective, or worse, may be harmful and advair.
The system establishes a number of patient classifications - diagnosis related group s ; drg.
In april 2004, timothy wright was appointed president of the company ’ s pharmaceuticals products division and aldactone.
Q1. What is the differential diagnosis? Q2. Outline how you would establish the definitive diagnosis.
Dr graham is also on staff of the gastroenterology section, veterans affairs medical center, houston and aldara.
After these findings were published in the journal of oral and maxillofacial surgeons, the us food and drug administration fda ; and the drug manufacturer, proctor & gamble, issued a warning to healthcare professionals and the general public about the increased risk of onj while on medications such as actonel.
Actonel risedronate
How supplied actonel is available as follows: 5 mg film-coated, oval, yellow tablets with rsn on 1 face and 5 mg on the other and alendronate!
Actonel is an oral bisphoshonate drug similar to fosamax and is manufactured by procter & gamble pharmaceuticals.
For two years i had no problems with actonel and amlodipine.
You should take your calcium supplement with your meals, far from the actonel pill, because calcium reduces the absorption of bisphosphonates.
That obtained from the trimegestone treated women. Trimegestone treated endometria were not different from those of the natural cycle, and there was no dose effect on the expression of MMP 1, 3, &9. Conclusions: We document here a cycle modulation of the expression of MMP9, as it was expressed more in the early and late luteal phases, but not MMP1 or MMP3. Trimegestone treated endometria did not exhibit a dose dependent effect on the expression of these MMPs. The endometrial expression of MMP1, 3 and 9 after 10 days of trimegestone administration does not explain the different bleeding phenomena. FC5.01.05 PREVALENCE OF PERSISTENT AMENORRHEA AND PREMATURE OVARIAN FAILURE IN SYSTEMIC LUPUS ERYTHEMATOSUS SLE ; . M.C. Cravioto, I. Escudero-Licona, A. Mendoza-Fuentes, J. RomeroDaz, J. Snchez-Guerrero, Instituto Nacional de la Nutricin, Vasco de Quiroga 15, Mexico City, D.F., Mexico, 14000. Objectives: To determine the prevalence of persistent amenorrhea PA ; and premature ovarian failure POF ; , and its associated factors, in women suffering from SLE. Study Methods: Cross-sectional study undertaken in 600 SLE patients and 300 age-matched controls: 150 women with rheumatoid arthritis RA ; and 150 with non-rheumatic chronic diseases CD ; . A face to face interview was conducted according to a pretested questionnaire which included menarche and cycle characteristics, parity, contraceptives and other drugs use. Women aged 40 ys who referred amenorrhea of 12 months were further studied. Serum concentrations of FSH, LH, E2, thyroid hormones, anti-thyroid antibodies and electrolytes, and urinary cortisol were quantified. POF was diagnosed when FSH was 30 mUI ml. Statistics: descriptive, square chi or Fisher exact test, t-test. Results: Prevalence of PA was 7% in SLE, 3% in RA and 2% in CD p 0.025 ; . The main cause of PA in SLE was POF 69% ; , followed by hysterectomy 9.5% ; , chronic anovulation 5% ; , and others. POF was associated with Cyclophosphamide use in 68%, and with other immunological disorders in 18 cases. Conclusions: The prevalence of PA is higher in SLE than in AR and other CD, and its main cause is constitued by POF: Because its clinical implications this diagnoses should be investigated in LES patients with PA. Partially supported by CONACYT, Mxico ; . FC5.01.06 SONOHYSTEROGRAPHY FOR EVALUATING THE ENDOMETRIUM IN MENOPAUSAL WOMEN MA Checa, R Carreras, A Garrido, M Vernet, R Villanueva. Hospital Universitario del Mar. UAB. IMAS. Barcelona. Spain. Introduction: Sonohysterography is a technique for evaluatig the uterine cavity. This is do it distension of uterine cavity with the instilation of an isotonic saline solution introduced by transcervical catheter. Sonography is easily and rapidly performed at a minimal cost. Objetives: 1.Evaluatin the efficacy of the sonohysterography in the exploration of the uterine cavity with classical transvaginal songraphy and hysteroscopy gold estndar ; in postmenopausal women. 2.Evaluation the applicability of the sonohysterography in postmenopausal asymtomatic women. Maerials and methods: We study 50 asymptomatic postmenopausal patients. They were eroled of our postmenopausal outpatients department. We practice a transvaginal sonography a sonohysterogrphy and an hysteroscopy. We study another aspects of the sonohysterography like: pain during the technique, pain 15 minutes after do it, cervical permeabilitation, centilitres of isotonic saline solution used, and pelvic infection ; . Results: Detection of endometrial patology in this orther, Histeroscopy, Sonography and Sonohysterography. Sensivity: 100%, 50%, 100%. Especifity: 100%, 97%, 100%. Positive predicting value: 100%, 80%, 100%. Discussion: Transvaginal sonography and sonohysterography had good especifity in the exploration the uterine cavity, the sonohysterography in this study has better sensivity and positive predicting value. Sonohysterography is well tolerated by patients and virtually devoid of complications. It can prevent further invasive diagnostic procedures and otimize the diagnostic of the uterine cavity when apear abnormal endometrial images by sonography and amoxycillin.
Apr 18, 2007 new england journal of medicine subscription ; , calne ry, williams kidney pathology in liver allograft recipients after long-term treatment with cyclosporin lab invest 1988; 5-40 the days of thriving kidney trade in city - jan 11, 2007 daily news & analysis, the recipients were given cyclosporin, potent immunosuppressive or anti-rejection drug, which had a rather alarming list of side-effects.
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Llm loliowlnpInstmilomare t ACTONEL6-np daily ; and ACmNElSSmp W W B Take A T fir9 Uling in UE IWMQ e h yw eat a m W excapt Mwdl c. C b and clavulanate and actonel!
Multinational study, the incidence of new vertebral fractures after 1 year was reduced from 13.3 to 5.6%, an absolute risk reduction of 8% and a relative risk reduction of 61% p 0.001 ; . In the North American study, the incidence of new vertebral fractures after 1 year was reduced from 6.4 to 2.4%, an absolute risk reduction of 4% and a relative risk reduction of 65% p 0.001 ; . At both 1 and 3 years, the reduction in risk seen in the subgroup of patients who had 2 or more vertebral fractures at study entry was similar to that seen in the overall study population. Treatment with Actoneel 5mg daily also significantly reduced the proportion of patients experiencing new and worsening vertebral fractures in each of the studies. Figure 1: Cumulative Incidence of New Vertebral Fractures.
Actonel and fosmax are both bisphosphonates , side effects about the same and ampicillin.
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At least in one position, in animal models, activates, guess what, the sympathetic nervous system. So what you might envision is a situation where you're either asleep and you can't protect your neck or you're simply driving the car and you're looking up at the light from time to time, you're bumping, literally bumping against your cervical spinal cord. And if you're constantly doing that intermittently you would expect to activate the sympathetic nervous system, turn on restless leg syndrome, turn on the fight or flight response and precipitate a situation where you're going to start losing stage IV sleep. In the Mirapex study, the dopamine medicine, no one was allowed to be in the study if they answered yes to those questions, if they had pain with extension of the cervical spine. Because the dopamine medicines treat the central brain. They treat the regulatory functions that control the fight or flight response. They try to restore normal sleep. They try to let you sleep. They don't treat the spinal cord. So when I look at patients I'd be very careful to understand who has fibromyalgia and also who might have this intriguing cervical issue that would be right under my nose. And there are now eight centers which will be doing this. This will be available at Northwest Hospital in Bellevue, Valley Medical Center and also University of Oregon and UCLA at Cedars-Sinai. ANDREW: Okay. So, interestingly, we had gotten a question from Mike in Port Orange, Florida who apparently had symptoms of fibromyalgia worsen after a car accident. So it sounds like that fits in with what you were just describing. DR. HOLMAN: Yes, exactly. And also people will describe it after surgery. Remember how they do anesthesia in surgery? They intubate people. They extend their neck to get the airway open to insert the endotracheal tube. ANDREW: That's what Lynne said at the beginning of the show. Right after surgery everything hurt. And she told me the other day even putting a sheet on her legs hurt. Her hair hurt, as she said. DR. HOLMAN: Absolutely true. ANDREW: I just want to mention, this kind of seeking the best care and trying to get past the suffering, that is, you know, across all illness. And I just want to mention a program that's coming up. The voice of the Seattle Seahawks is also a TV anchorman in town, Steve Raible, who used to be a wide receiver for many years with the Seahawks. Well, his wife of 25 years, Sharon, has lupus, another rheumatologic condition. It's an autoimmune condition. Has some of the symptoms but different from fibromyalgia. 8.
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These medicines are available actoenl only with your doctors prescription, in the following dosage forms: they actnel are also used to help decrease the size of enlarged thyroid actonel glands known as goiter and to treat thyroid cancer.
A ACCU-CHEK STRIPS AND KITS ACCUNEB ACTONEL ACTONEL WITH CALCIUM ACTOPLUS MET ACTOS acyclovir ADVAIR albuterol ALLEGRA-D 4 ALPHAGAN P ALTACE amoxicillin amoxicillin-clavulanate ANDROGEL ASMANEX ASTELIN ATACAND 2 ATACAND HCT atenolol AVALIDE AVANDAMET AVANDARYL AVANDIA AVAPRO AVELOX azithromycin B BD INSULIN SYRINGES AND NEEDLES BETIMOL BETOPTIC S BIAXIN XL brimonidine 0.2% bupropion bupropion ext-rel C CADUET captopril cefaclor CENESTIN cephalexin CIPRO SUSPENSION CIPRO XR ciprofloxacin tablet clarithromycin CLIMARA COMBIVENT COPAXONE COREG COZAAR CRESTOR CYMBALTA D DETROL DETROL LA dicloxacillin diltiazem ext-rel DITROPAN XL doxazosin doxycycline hyclate DUONEB E EFFEXOR EFFEXOR XR enalapril ENJUVIA erythromycins ESTRADERM estradiol estropipate EVISTA F fexofenadine FLOMAX FLOVENT fluoxetine fluticasone FORADIL FOSAMAX FOSAMAX PLUS D G glipizide glipizide ext-rel glyburide glyburide micronized H HUMALOG HUMULIN HYZAAR and acyclovir.
Actonel will not work if you stop taking it!
8.1.3 Insulin Sensitizers famotidine X Actoplus Met PA, QL X nizatidine X Actos PA, QL X ranitidine X Avandamet PA, QL X Pepcid RPD X famotidine Avandaryl PA, QL X Zantac Efferdose, X ranitidine Zantac Granules Avandia PA, QL X 9.4.1 Other Antiulcer Drugs Duetact PA, QL X Actos + glimepiride misoprostol X 8.1.4 Amylin Analogues sucralfate X Symlin PA X 9.4.2 Proton Pump Inhibitors 8.1.5.1 Incretin Mimetics omeprazole X Byetta PA, QL X Aciphex QL, ST X omeprazole, Protonix, Prevacid 8.1.5.2 DPP-iV Inhibitors Nexium QL, ST X omeprazole, Protonix, Prevacid Janumet PA, QL X Prevacid QL, ST X omeprazole Januvia PA, QL X 8.3.1 Glucocorticoid Drugs Prevacid Solutabs ST X omeprazole dexamethasone X Prilosec 40 mg QL, ST X omeprazole, Protonix, Prevacid hydrocortisone X Protonix QL, ST X omeprazole methylprednisolone X Zegerid packets capsules QL, ST X omeprazole, Protonix, Prevacid prednisolone X Omeprazole is always the first Use of all 3- omeprazole, Prevacid, and Protonix line product. Prevacid or prednisone X must be noted within past Protonix can only be obtained if Orapred ODT tabs X 130 days for Aciphex, omeprazole has been used 8.4.1 Thyroid Supplements Nexium, Zegerid, or within the past 60 days. levothyroxine sodium X Prilosec 40 mg to Armour Thyroid X process Cytomel X 9.4.3 Helicobacter Pylori Drugs 8.4.2 Anti-Thyroid Drugs Helidac X methimazole X Prevpac QL X propylthiouracil PTU ; X 9.6 Other GI Drugs 8.6 Other Endocrine Drugs glycolax X cabergoline QL X peg 3350 & electrolytes X desmopressin tabs nasal X sulfasalazine X solution Asacol X Fortical ST X Actonel, Fosamax AnaMantle HC X Actpnel QL X Azulfidine En-Tab X Asacol, sulfasalazine Actoonel with Calcium QL X Canasa X Aldurazyme PA, SP X Colazal ST X Asacol, sulfasalazine Boniva QL, ST X Actonel, Fosamax Cotazym, Cotazym-S X Cerezyme PA, SP X Creon X DDAVP SP X Dipentum ST X Asacol, sulfasalazine Didronel ST X Actonel, Fosamax Entocort EC X Dostinex QL X Elaprase PA, SP X Lialda ST X Fabrazyme PA, SP X Moviprep X peg 3350 & electrolytes Forteo PA, SP X Actonel, Fosamax Nulytely X peg 3350 & electrolytes Fosamax QL X Osmoprep X peg 3350 & electrolytes Fosamax plus D QL X Pancrease E X Miacalcin ST X Actonel, Fosamax Pentasa X Asacol, sulfasalazine Myozyme PA, SP x Peranex HC X OTC hydrocortisone + lidocaine Naglazyme PA, SP X ointment, AnaMantlle HC Sensipar SP X Rectagel HC Gel X OTC hydrocortisone + lidocaine Stimate SP X ointment, AnaMantle HC Somavert PA, SP X Rowasa X Skelid ST X Actonel, Fosamax Zymase X Zavesca PA, SP X Halflytely X peg 3350 & electrolytes Chapter 09 Gastrointestinal Medications Miralax X glycolax 9.2 Antidiarrheal Drugs Ultrase MT X diphenoxylate w atropine X Urso Forte X 9.3 Antispasmodics Drugs Affect GI Motility Visicol X peg 3350 & electrolytes dicyclomine X 9.7 Irritable Bowel Drugs dispas X Amitiza QL X hyoscyamine X Lotronex X methscopalamine Br X Zelnorm X metoclopramide HCl X Chapter 10 Immunologicals and Vaccines IB-Stat QL X 10.0 Immunologicals and Vaccines Mar-Spas X hyoscyamine, dispas Vivaglobulin 16 % PA, SP X limited distribution Nulev X 10.2.1 Myeloid Stimulants Pro-Hyo X hyoscyamine, dispas Leukine SP X Symax Duotab X hyoscyamine sulfate ER Neulasta QL, SP X Neupogen, Leukine 9.4 Antiulcer Drugs Neupogen SP X cimetidine X PA Prior Authorization Required QL Quantity Limits if exceeded, prior auth. required ; ST Step Therapy if criteria not met, prior auth. required ; E Drugs Exempt from Generic Substitution G Generic Drug Substitution Applies SP Specialty Pharmacy 13.
Prevention of Asbestos-Related Diseases in Hungary, Estonia and Karelian Republic of the Russian Federation Project number: IC15-CT96-0301 EU contribution: 350.000 Duration: 30 months Teams countries: FIN, D, HU, S, EE, RU Keywords: asbestos, cancer, occupational health.
Dr. Aubrey Blumsohn was a researcher at the University of Sheffield in the United Kingdom when Procter & Gamble P&G ; commissioned the university to study Actonel's effectiveness. P&G hoped that the study would show that Actonel, an osteoporosis drug, was as effective as Merck's best seller Fosamax even though it has smaller effects on bone turnover. P&G published ghost-written medical journal abstracts in Blumsohn's name arguing the science even as P&G refused to let Blumsohn analyze the completed data set. Under pressure from GAP, P&G recently released a full data set to Blumsohn. The company also issued a researchers' Bill of Rights, which ensures that researchers will have access to all data relevant to their work, and final authority over all materials published in their name. Blumsohn has been discussing what happened on his blog at scientific-misconduct spot . Clark: Can you describe your work at the university and your research on Actonel? Blumsohn: The University of Sheffield is a great university. I did my PhD there a long time ago. I came back to the university in 2000 as a senior academic within their bone group. I primarily did research but also clinical work and some teaching. I was running the bone metabolism laboratory at the university's internationally known clinical bone research unit. We were approached by P&G in 2002 to perform measurements on the samples that had been archived as part of the trials for Actonel's registration. Clark: Did you get any sense that P&G wanted to do anything other than pure science? Blumsohn: Yes, the problem emerged almost from the beginning. P&G authored meeting reports, statistical reports and draft publications based on the data we generated, all in my name, while simultaneously denying me the right to see the raw data about which they were writing. This was in breach of the principles of science, P&G's contract with the university, and every bit of guidance that is out there about the way science should work. Unfortunately, I think this does happen a lot more than physicians, doctors and scientists like to think. To be clear, about the data normally when you do measurements you do them blind, so you don't know which patients got the drug and which patients got the placebo. The company held those codes and they refused to provide us with them, so we couldn't make heads or tails of the results. I started approaching the issue, explaining that I wasn't prepared to author pieces for pharmaceutical companies while they were computing the statistics and not allowing us to verify the information. P&G had a string of increasingly bizarre excuses explaining why they weren't going to allow us to see the data in these studies. Clark: Were you pressured at some point to sign an article for publication?.
Table 4. Karvonen's Formula for Determining Exercise Intensity Using Heart Rate, because actonel osteoporosis.
Fosamax increased bmd 62 percent more than actonel at the hip trochanter hip bone ; , with similar tolerability.
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