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The aim of the Partial Agreement public health activities is to protect the consumer from potential risks connected with the present-day way of life. The committees of experts provide the scientific base for national and international regulations concerning products which have a direct or indirect impact on the human food chain control of foodstuffs, nutrition, food safety, consumer health, food contact materials, flavouring substances ; , pharmaceuticals and cosmetics, because arava online.
Objectives: A study was made on the level of urinary function disorder in type III radical hysterectomy with or without complete cutting of lower hypogastric nerve plexus. Study Methods: Comparison of the group which was cut the lower hypogastric nerve plexus as the sacro-uterine ligament 17 cases, nonconfirmed group ; and the group which was not cut 13 cases, confirmed group ; . Results: Pelvic splanchinic nerve at the lower cardinal ligament was parasympathetic nerve and lower hypogastric nerve plexus at the sacrouterine ligament was sympathetic nerve. They were adjoin at pelvic nerve plexus at the level of parametrium and called pelvic plexus. From pelvic plexus, bladder supply nerves were divided at the superficial level of paravaginal fascia contraction of bladder wall ; and the deep level of paravaginal fascia filling sensation of urinary bladder and contraction of urethral sphincter ; . Sacro-uterine ligament was contained mesorectum and lower hypogastric nerve plexus. Comparison of the two groups was made by urine test. The results showed that the cases in which urine test could be completed within two weeks was 13 100% ; in confirmed group and 10 17 58.8% ; in non-confirmed group p 0.05 ; . Furthermore, in all cases belonging to confirmed group there was a sensation of urinary bladder filling. Conclusions: Operative procedure was established in type III radical hysterectomy to evade urinary disturbance by retaining a part of sympathetic nerve lower hypogastric nerve plexus ; and parasympathetic nerve supplying urinary bladder. FC2.25.05 ANATOMY FOR THE GYNECOLOGIC SURGEON: A CORRELATIVE EXAMINATION OF PELVIC ANATOMY IN FIXED CADAVERS AND LIVE OPERATIVE PROCEDURES R.J. Scotti, G. Lazarou, Dept. OB GYN and Women's Health, Montefiore Medical Center Albert Einstein College of Medicine, Bronx, New York, USA. Objective: The aim of this study is to perform detailed pelvic dissections on fixed cadavers and to correlate the anatomic findings with live operative procedures. Study Methods: 15 fixed female cadavers were dissected, exposing the pelvic floor, retropubic space, presacral space, and pelvic sidewall. Meticulous sharp and blunt dissection was performed and important anatomic landmarks in the pelvis were identified, including the vaginal wall fascia muscularis, arcus tendineus fascia pelvis white line ; , obturator fascia and muscle, ischial periosteum, Cooper's ligament, sacrospinous ligament and presacral fascia. Photographs of the appropriate sites were obtained. Results: Most of the important anatomic landmarks in the pelvis were identified in the cadavers. The arcus tendineus, however, was not identified in 2 of 13% of the specimens ; . These dissections correlated well with live operative procedures, allowing the surgeon and physicians to corroborate findings inoperative procedures such as Burch colposuspension, paravaginal repairs, abdominal sacral colpopexy, etc. The cadaver lab, however, progressed at a more leisurely pace than the operating room, providing time for thorough discussion, feedback and exploration of neighboring structures, including the nerve and blood supply to these structures. Conclusion: Cadaveric dissections provide a methodical detailed study of pelvic anatomy for gynecologic surgeons in training. Cadaveric dissections correlate well with surgical findings, permitting for proper identification of vital structures and important landmarks in the pelvis. The anatomy lab experience with photo documentation had proved to be a valuable educational experience.
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In the past, methotrexate was used to treat rheumatoid arthritis patients until the fda approved arava leflunomide ; , manufactured by aventis pharmaceuticals in september 199 since then, the fda has received 130 reports of severe arava liver toxicity that includes 56 hospitalizations and 12 deaths.
OXNORM ; was aimed at elaboration of cell culture models and cultivation methods that would more precisely simulate the physiological conditions in tissues in vivo, particularly with respect to pericellular oxygen concentrations. The same consortium later succeeded in application for the project within the 6th Framework Program. The integrated project EUROXY "Targeting newly discovered oxygen- sensing cascades for novel cancer treatments. Biology, equipment, drug candidates" is focused on study of hypoxia that occurs in solid tumors due to insufficient delivery of oxygen to tumor cells via aberrant vasculature. In the process of adaptation to hypoxia, tumor cells acquire capability to metastasize and resist conventional therapy. Hypoxia is therefore significantly associated with poor prognosis of cancer. The major aims of the projects include: 1 ; to elucidate the effects of hypoxia on gene transcription and translation, cell proliferation, differentiation and survival and on additional cell parameters, 2 ; to define molecular pathways induced by hypoxia, with emphasis on the main regulator of hypoxic responses HIF and its target molecule CA IX, characterize their functions and development of strategies for their negative regulation and targeting, 3 ; to determine diagnostic and prognostic potential of molecular markers of tumor hypoxia, select the molecules suitable for detection of hypoxic tumors and for targeted anticancer therapy. Our role in the project is to study the regulation, function and potential clinical applications of the carbonic anhydrase IX. Our most important contribution was elucidation of the role of CA IX acidification of extracellular microenvironment in response to hypoxia and demonstration of the selective binding of CA IX inhibitors to hypoxic tumor cells. The latter became a proof of principle that CA IX-selective inhibitors can be used as in vivo imaging agents for detection of hypoxic tumors. The "Integrated Consortium on Ticks and Tick-borne Diseases" of the 6 and axid.
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We lost track of time in the dizzying mix of photos, sun, and euphoria. I lost my bearings and took one step too close to the steep ridge for Simon's comfort. "Time to go, " he proclaimed. Our caravan of six continued along the ridge descending quickly off the ice and rock-bound mountain, through Alpine desert and down to lunch. Climbing Kilimanjaro is at best a fool's errand. It was difficult, serene, monumental, and lonely all at once, not everyone's idea of a vacation. I was not the first to achieve the summit, nor the 10, 000th, nor the fastest. I didn't climb to the top-shelf of the atmosphere on New Year's Day or Christmas or any monumental date--and I certainly won't be the last climber. Our world often asks us to act backwards. Events occur first, thought and reaction follow. But in a world where we dream liberally but act conservatively, I'm comforted knowing that for one week in an otherwise sheltered life, I indulged my delusions of grandeur. Thoughtfully planning and proactively overcoming a mountain and rewarded by her with a continent to survey. To challenge yourself constantly and even occasionally succeed fuels new dreams, allowing me to welcome an often obscured future. I came to this conclusion on the plane home, almost five days after Uhuru Peak, but I think my body was already aware. After all, on the summit, my tears froze, wind-burning my face and azithromycin.
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Toll the limitations period. Ark. Code Ann. 11-9-702 g ; 1 ; Repl. 1996 Cromwell v. University of Arkansas, 76 Ark. App. 5 , 61 S.W.3d 864 2001 ; . It has long been held that the statute of limitations does not commence to run until the true extent of the injury manifests and causes an incapacity to earn wages sufficient to give rise to a claim for disability benefits. Hall's Cleaners v. Wortham, 311 Ark. 103, 842 S.W.2d 7 1992 ; . In Pina v. Wal-Mart Stores, Inc., Ark. App. , at , S.W.3d , at May 11, 2005 ; , the Court of Appeals held that the statute of limitations in a carpal tunnel case begins to run when the scheduled injury becomes apparent to the claimant. See, Cottage Caf, Inc. v. Collette, CA 05-734, Ark. App. 2-1-2006 ; Reversed and remanded for determination of when claimant became aware of injury ; . The claimant in the instant case reported the accident involving the wheelchair on July 2, 2001. Medical records reflect that she sought treatment for the injuries associated with the fall on July 12, 2001. Claimant filed her workers' compensation claim on September 25, 2003. In the instant case, claimant's condition became apparent to her by at least July 12, 2001. Following the fall, the claimant was treated conservatively and was able to return to work without restrictions. I find that because the claimant did not file her claim for benefits arising from the July 2, 2001 accident until September of 2003, the claim is barred by the statute of limitations. Claimant now contends that the later surgical procedures and treatment for injuries to her right hand, right knee, and right shoulder were a result of the fall. For the reasons set forth herein, I find that claimant has failed to prove by a preponderance of the evidence any causal connection between the fall at work in July of 2001 and the subsequent treatment for her right hand, knee, or shoulder, for example, arava 201.
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The RPR and VDRL venereal disease research lab ; are the most widely used of the older, non-specific reagin tests. They can be transiently positive in a wide range of viral and autoimmune diseases as well as syphilis and yaws. After successful treatment of syphilis, the RPR VDRL titre declines and may become negative. The RPR VDRL is used as a screening test for syphilis and for monitoring response to treatment. A positive result may be due to: current infection rare in New Zealand. The titre will nearly always be 1: 16 past, inactive, treponemal infection the titre is usually 1: 16, often 1: or SLE the "biological false positive RPR" is found in 10-20% of SLE and is one of the serological markers other autoimmune diseases, including antiphospholipid syndrome viral infections, malaria and Mycoplasma pneumonia infections positive for 6 months parenteral drugs aging.
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| Arava medicine priceWE demand a lot from antibiotics. When used properly, they are our No. 1 tool for controlling bacterial infections. But, improper administration can result in poor therapeutic results, increased costs from discarded milk, and wasted labor and drugs. Dairy producers often must make decisions on when antibiotic therapy should be given and how it should be administered. Many variables, of course, affect the outcome of antibiotic therapy, making it impossible to expect successful results for every case. However, with the right training and a basic understanding of how antibiotics work, dairy producers can avoid many of the most common pitfalls of antibiotic therapy, and have more productive conversations with their veterinarians. The key is to use antibiotics correctly, and in a judicious manner, to ensure their effectiveness and to reduce possible side effects. An important step is to separate myths from facts, and I hope the information below will help you achieve greater success in the treatment of bacterial infections.
Weekly docetaxel Taxotere ; in patients with metastatic breast cancer H.J. Stemmler, K. Gutschow, H. Sommer, M. Malekmohammadi, Ch. Kentenich, R. Forstpointner. S. Geuenich, J. Bischoff, W. Hiddemann & V. Heinemann 1393 A phase II study evaluating the tolerability and efficacy of CAELYX liposomal doxorubicin, Doxil ; in the treatment of unresectable pancreatic carcinoma S. Halford, D. Yip, C.S. Karapetis. A.H. Strickland, A. Steger, H.T. Khawaja & P.G. Harper 1399 A phase II study of gemcitabine in gallbladder carcinoma JO. Gallardo, B. Rubio, M. Fodor, L. Orlandi. M. Yanez, C. Gamargo & M. Ahumada 1403 A phase II study of epirubicin, cisplatin and raltitrexed combination chemotherapy ECT ; in patients with advanced oesophageal and gastric adenocarcinoma H.J. Mackay. A. Mclimes, J. Paul, N. Raby, F.J. Lofts, A.C. McDonald, M. Soukop, G.M. Fullarton, A.L. Harris, J Garcia-Vargas & T.R.J. Evans 1407 Multicenter phase II--III study of oxaliplatin plus cyclophosphamide vs. cisplatin plus cyclophosphamide in chemonaive advanced ovarian cancer patients J.-L. Missel, Ph. Vennin, Ph. Chollet, P. Pouillart, Ph. Laplaige. J.L. Frobert, D. Castera, M. Fabro, D. Langlois, E Cortesi, V. Lucas, E. Gamelin, A. Laadem &J.Otero 1411 Combination chemotherapy with gemcitabine and ifosfamide as second-line treatment in metastatic urothelial cancer. A phase II trial conducted by the Hellenic Cooperative Oncology Group D. Pectasides, G. Aravantinos, H. Kalofonos, C Kiamouris, D Bafaloukos, N. Xiros, C. Nicolaides, A. Visvikis & M.A. Dimopoulos 1417 Alterations of routine blood tests in adult patients with soft tissue sarcomas: Relationships to cytokine serum levels and prognostic significance W. Ruka, P. Rutkowski, J. Kaminska, A. Rysinska & J Steffen 1423 Comparison of the effects of intravenous pamidronate and oral clodronate on symptoms and bone resorption in patients with metastatic bone disease S.P. Jagdev, OP. Purohit, S. Healley, C. Herling & R.E. Coleman 1433 Dexamethasone, high-dose cytarabine, and oxaliplatin DHAOx ; as salvage treatment for patients with initially refractory or relapsed non-Hodgkin's lymphoma D. Machover, B. Delmas-Marsalet, S. C. Misra. Y. Gumus, E. Goldschmidt. A. Schilf, N Frenov, J.-F Emile, B. Debuire, C Guettier. P. Fanokhi, B. Boulefdaoui, F. Norol. N. Parquet. A. Ulusakarya & C. Jasmin 1439 Continued overleaf.
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Software abstracts Marc Lavielle SAEM in MATLAB: an alternative to linearization Posters Thursday Day 1 ; 1. Anthe Zandvliet Population pharmacokinetics of caffeine and its metabolites theobromine, paraxanthine and theophylline after inhalation in combination with diacetylmorphine 3. Ken Kowalski WAM Wald's Approximation Method ; : A User-Friendly Software Program for Efficient Covariate Model Building 5. Sophie Gisbert Different approaches to the development of a WBPBPK model with a series of barbiturates using population modelling 7. Kayode Ogungbenro The Design of Population Pharmacokinetic Studies: Sample Size Determination 9. Thorsten Lehr Clock time as a control variable for gall bladder emptying in an enterohepatic circulation model 11. Elaine Blair Pharmacokinetic-Pharmacodynamic Modelling of Raltitrexed in Patients with Advanced Solid Tumours 13. Holger Kraiczi Effect of Uncertainty About Population Parameters on Pharmacodynamics-Based Prediction of Clinical Trial Power - A Method for Sensitivity Analysis 15. Bart Ploeger The reversal of rocuronium-induced neuromuscular block by the cyclodextrin ORG25969: model development and validation 17. Teun Post A Mechanistic Disease Progression Model for Type 2 Diabetes Mellitus and Pioglitazone Treatment Effects 19. Mike Smith A Bayesian design and analysis for dose-response using informative prior information 21. Elspeth Lamont Population Pharmacokinetics of Teicoplanin in Outpatient Home Parenteral Antibiotic Therapy OHPAT ; 23. Matthew Zierhut Development and Evaluation of a Population PK PD Model for Fc-OPG in Healthy Postmenopausal Women 25. Aris Dokoumetzidis Propagation of population pharmacokinetic information using a Bayesian approach 27. Marc Pfister Characterization of Cortisol Circadian Rhythm and Lack of Cortisol Suppression by a New Corticosteroid, Ciclesonide 29. Vladimir Piotrovsky Population pharmacokinetic analysis of concentration data after implantation of sirolimus-eluting Bx Velocity stent in patients 31. Karl-Heinz Liesenfeld Population pharmacokinetics of a new anticoagulant drug in clinical development 33. Jean-Eric Charoin Population Pharmacokinetic Analysis of Trastuzumab Herceptin ; following LongTerm Administration Using Different Regimens. 35. Jeff Barrett Esmolol Population Pharmacokinetics in Critically-ill, Pediatric Patients 37. Jakob Ribbing Learning about Covariate Relations in the Patient Population Based on Data from Multiple Studies Consequences of Different Approaches 39. Lena Friberg Simultaneous fit of competing models as a model discrimination tool in Bayesian analysis 41. Hugo Maas Comparison of sumatriptan and naratriptan using a markov model approach 43. Francesco Fiorentini An example of application of the population approach to toxicological studies. 45. Annick Rousseau Modeling the complex pharmacokinetic profiles of cyclosporin and of mycophenolate observed in the early post-transplantation period. 47. An Vermeulen Modeling the occurrence of orthostasis using a longitudinal logistic regression model 49. Brian Mc Hugh Population PK and PK PD Analyses of an Enzyme Inhibitor in Healthy Volunteers 51. Lia Liefaard Application of Population Pharmacokinetic Analysis for Quantification of in vivo Binding Properties in the Rat Brain by Positron Emission Tomography 53. Willi Weber Comparing efficacy of 10mg vs 20mg ARAVA in treatment of rheumatoid arthritis: A Population PK PD Analysis 55. Rune Overgaard Non-Linear Mixed Effects Models with Stochastic Differential Equations Implementation of an Estimation Algorithm 57. John C Lukas The cytochrome P450 3AP1 variant genotype shows correlation with the true clearance in a renal transplant population.
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Michael Weisman, MD Director, Division of Rheumatology Cedars-Sinai Medical Center Los Angeles, CA Daniel E. Furst, MD Director, Arthritis Clinical Research Unit Virginia Mason Research Center Seattle, WA Jan Hillson, MD Fellow Member Virginia Mason Research Center Seattle, WA.
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Integrated Water Resources Management in the Middle East 6 Feb 2006 - 17 Feb 2006 Kibbutz Ketura, Israel Dr. Eric Pallant Allegheny College, Meadville, United States Fax: 814 332 2789 E-mail: epallant allegheny ; Dr. Clive Lipchin Arxva Institute for Environmental Studies, D.N. Hevel Eilot, Israel Fax: 814 332 2789 E-mail: clive arava ; natowater ESP.981407 Climate Change Impacts on Marine Environment 14 Aug 2006 - 26 Aug 2006 Ankara, Turkey Prof. Temel Oguz Middle East Technical University, Erdemli, Turkey Fax: 90 324 521 E-mail: oguz ims.metu .tr ; Prof. Mohamed Nejib Daly Yahia University 7 November at Carthage, Tunisia Fax: 90 324 521 E-mail: najib.daly fsb.rnu.tn ; : ims.metu .tr SummerSchool index.
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In this analysis we still rely on the assumptions made by Rosen 1974 ; and use the theory of hedonic price function on Finnish rental housing market [FRM] to estimate hedonic prices and coefficients for the characteristics of dwelling units. The primary objective in this paper is to study the differences in the rental price formation between the two sub-markets Free and Srava market ; . Adava market is subsidized by lower interest rates and the owners are so called non-profit organisations directed by different regulations, mostly municipalities. Free market is totally free of any restrictions except what concerns unreasonable high rent drifts. As both of the markets are equal in size in Finland, is our rental market an interesting "laboratory" to compare subsidized and free market also for international purposes and generalizations. The second objective is to estimate the differences in the growth of rents by regions. Thirdly preliminary models about Finnish total rental data in1998, 2001 and 2003 are being estimated for free and subsidized market.
CONCLUSION: ICG readily identifies subclinical systolic abnormalities associated with obesity. CLINICAL IMPLICATIONS: ICG provides an easily applicable tool for early detection of subclinical cardiac functional changes associated with obesity. DISCLOSURE: Julio Chirinos, None. DIAGNOSTIC UTILITY OF THORACIC ULTRASONOGRAPHY FOR FOLLOWING UP OF CHRONIC HEART FAILURE PATIENTS Hajime Kataoka MD, MSc * Nishida Hospital, Saiki, Japan PURPOSE: The aim of this study was to determine the usefulness of thoracic ultrasonography for detecting deterioration in chronic heart failure HF ; patients during follow-up. METHODS: A total of 46 stable chronic HF patients at entry were followed up between June 2003 and September 2005. Evaluated HFrelated variables included symptoms, signs, pleural effusion on an ultrasonogram and plasma brain natriuretic peptide BNP ; levels. RESULTS: During the study period, 26 patients developed acute on chronic HF decompensation and 20 maintained a stable clinical course. Twenty-five decompensated HF patients 96% ; demonstrated objective HF-related sign s ; under examination. Among the HF-related signs tested in the present study, pleural effusion on an ultrasonogram was the leading HF-related sign 77% ; , followed by rales 46% ; and edema 46% ; . Eleven patients 42% ; presented with only one feature of HF-related signs, in which pleural effusion on an ultrasonogram was the most frequent sign 7 of 11 patients ; . Based on the plasma BNP levels as reference for HF decompensation, the detection of pleural effusion by ultrasonography exhibited the best sensitivity 74% ; , best negative predictive value 73% ; , and the highest predictive accuracy 78% ; for identifying patients with higher BNP levels at decompensation than during stable periods. CONCLUSION: With a high sensitivity, pleural effusion on an ultrasonogram is able to detect many chronic HF patients with deterioration, and the excellent negative predictive value of this sign could allow excluding the possibility of decompensated status in chronic HF patients during follow-up. CLINICAL IMPLICATIONS: The ultrasonographic method is an evolving imaging modality that has found new uses in critically ill patients including HF patients. The present study has firstly shown the diagnostic utility of thoracic ultrasonography for following up of chronic HF patients. DISCLOSURE: Hajime Kataoka, None. WHAT IS THE INCIDENCE OF STROKE AMONG RURAL INDIGENT HEART FAILURE PATIENTS ON CURRENT STANDARD MEDICAL THERAPY? Kathy Hebert MD, MMM, M Ron Horswell PhD Zaza Katsarava MD Lee M. Arcement MD, MPH * Chabert Medical Center, Houma, LA PURPOSE: Systolic heart failure SHF ; is the second most common cause of cerebrovascular events CVE ; in the US after atrial fibrillation. Previous studies have measured the annual incidence of CVE in patients with SHF with values as high as 5.5%. In CAD, the annual incidence is 3.4%, where as in healthy men, it is 0.95%. These observations were conducted prior to the current era of neurohormonal blocking agents as standard SHF therapy. The COMET trial compared carvedilol to metoprolol tartrate in SHF and revealed a 65% stroke reduction in the carvedilol cohort. We aimed to ascertain the incidence of CVE in a rural indigent SHF population receiving standard medical therapy including beta blockers. METHODS: Four hundred eighteen patients followed in a SHF disease management program in rural South Louisiana were prospectively screened from January 2005 to December 2005 at each visit for the occurance of a new stroke or TIA as ascertained by the presence of any one of the five warning signs of CVE as established by the NINDS. RESULTS: The 1 year incidence of CVE is 1.91% n 8 ; in the population. All of these were CVA's. There were no significant differences between groups regarding mean age, mean EF, gender, race, % atrial fibrillation, % history of CVE, systolic blood pressure, NYHA class, payment status, % smokers, % diabetes, aspirin usage or usage of Ace inhibitors and beta blockers. Medium income of the population is $11, 800 year. Beta blocker use 95% carvedilol usage in both groups ; is 100% in the CVE group vs. 97.8% in the non CVE group n 410 ; . Ace inhibitor usage was 100% in the CVE group vs. 96.1% in the non CVE group. CONCLUSION: CVE incidence in a rural indigent SHF population on standard medical therapy is higher than the general population but lower than previously reported in heart failure populations. CLINICAL IMPLICATIONS: Whether this decreased incidence of CVE is due to the widespread usage of standard neurohormonal blocking agents or other factors in this population requires further study. DISCLOSURE: Lee Arcement, None.
Active Studies S0528, "A Phase I Study Evaluating the Combination of Lapatinib GW572016 ; and Everolimus RAD001 ; in Patients with Advanced Solid Tumors." Dr. S. Gadgeel. Activated: 9 1 06. Closed Studies S0355, "A Phase I Pharmacokinetic Study of Epothilone B Analogue BMS-247550 NSC 710428D ; in Patients with Advanced Malignancies and Varying Levels of Liver Dysfunction." Dr. A. Davies. Activated: 11 1 03. Closed: 8 15 06. Proposed Studies S0711, "A Phase I Trial of Dasatinib BMS-354825 ; in Patients with Advanced Malignancies and Varying Levels of Liver Dysfunction." Dr. J. Sarantopoulos. S0716, "Phase I Study of the Pharmacokinetics and Pharmacodynamics of ZD6474 in Combination with Docetaxel in Advanced Solid Tumors." Dr. D. Wang. S0718, "Phase I Study Evaluating the Combination of GW786034 Pazopanib ; and CCI-779 Temsi-rolimus ; in Patients with Advanced Solid Tumors." Dr. A. Davies. Other Business Open Discussion.
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