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The following medications have been reviewed by the Pharmacy and Therapeutics Committee P&T ; and added to the Health Partners Formulary for 2004. They do not need prior authorization. If you have questions, please call the Pharmacy department at 215-991-4300. Medications: Abilify Actos Aldara Alocril Avelox Benicar Benicar HCT Benzaclin Gel Benzamycin Pak Benzamycin Topical Gel Cefzil Cipro XR Cosopt Dettol Edtrol LA Foradil Humalog Humalog Mix 75 25 Klaron Lotion Lexapro Lexiva Lipitor Lumigan Nexium Novolog Novolog Mix 70 30 Omni-Pac Penlac Pravigard PAC Proventil HFA Pulmicort Turbuhaler Relpax Renagel Reyataz Rhinocort Aqua Strattera Tarka Tazorac Tricor Zetia Zoloft Zymar To view the entire Health Partners Formulary, log on to our website at healthpart , and click on "Info for Providers." This information can be printed from the website. Those without internet capabilities can call the Provider Services Helpline at 215-991-4350 or 1-888-991-9023 to request a printed copy.
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59. DetrolTM tolterodine tartrate tablets ; prescribing information. Kalamazoo, Mich: Pharmacia & Upjohn Co; June 2000 ; . 60. Dettol LA tolterodine tartrate extended release capsules ; prescribing information, Kalamazoo, Mich: Pharmacia & Upjohn Co; June 2002 ; . 61. Van Kerrebroeck P Kreder K, Jonas U et al., "Tolterodine once-daily: superior efficacy and tolerability in the treatment of urinary , urge incontinence", Urol. 2001 57: pp. 414421. 62. Drutz H P , Appell R A, Gleason D, Klimberg I, Radomski S, "Clinical efficacy and safety of tolterodine compared to oxybutynin and placebo in patients with overactive bladder", Int. Urogynecol. J. Pelvic Floor Dysfunct. 1999 10: pp. 283289. 63. SancturaTM trospium chloride 20 mg tablets ; prescribing information, East Hanover, NJ: Odyssey Pharmaceuticals, Inc; Lexington, MA: Indevus Pharmaceuticals, Inc.; July 2004 ; . 64. Pak R W Petrou S P Staskin D R, "Trospium chloride: a quaternary amine with unique pharmacologic properties", Curr. Urol. Rep. 2003 4: pp. 436440. 65. Madersbacher H, Stohrer M, Richter R, Burgdorfer H, Hachen H J, Murtz G, "Trospium chloride versus oxybutynin: a randomized, double-blind, multicentre trial in the treatment of detrusor hyper-reflexia", Br. J. Urol. 1995 75 4 ; : pp. 452456. 66. Enablex extended-release tablets ; prescribing information. East Hanover, NJ: Novartis Pharmaceuticals Corp; December 2004 ; . 67. Chapple C R, "Muscarinic receptor antagonists in the treatment of overactive bladder", Urol. 2000 55 5A suppl ; : pp. 3346. 68. Chapple C R, Rechberger T, Al-Shukri S, Meffan P et al., "Randomized, double-blind, placebo- and tolterodine-controlled trial of the once-daily antimuscarinic agent solifenacin in patients with symptomatic overactive bladder", BJU Int. 2004 93 1 ; : pp. 303310. 69. Haab F Stewart L, Dwyer P "Darifenacin, and M3 selective receptor antagonist, is an effective and well-tolerated once-daily treatment for overactive bladder", Eur. Urol. 2004 45 4 ; : pp. 420429. 70. Ikeda K, Kobayashi S, Suzuki M et al., "M 3 ; receptor antagonism by the novel antimuscarinic agent solifenacin in the urinary bladder and salivary gland", Naunyn Schmiedebergs Arch. Pharmacol. 2002 366 2 ; : pp. 97103. 71. VESIcare solifenacin succinate ; prescribing information, Research Triangle Park, NC: GlaxoSmithKline; November 2004 ; . 72. Chapple C, Wyndaele J, Gronen S, "Solifenacin provided statistically significant and clinically relevant reductions in urgency, a defining symptom of overactive bladder. Solifenacin Study Group", presented at: the International Continence Society Annual Congress; 2327August 2004 Paris, France. Abstract 276. 73. Thakar R, Stanton S, "Regular review: management of urinary incontinence in women", BMJ 2000 321: pp. 1, 3261, 331. Wein A J, Rovner E S, "Pharmacologic management of urinary incontinence in women", Urol. Clin. N. Am. 2002 29: pp. 537550. 75. Cardozo L, Lose G, McClish D, Versi E, "A systematic review of the effects of estrogens for symptoms suggestive of overactive bladder", Acta. Obstet. Gynecol. Scand. 2004 83: pp. 892897. 76. Simunic V Banovic I, Ciglar S et al., "Local estrogen treatment in patients with urogenital symptoms", Int. J. Gynaecol. Obstet. , 2003 82: pp. 187197. 77. Hendrix S L, Cochrane B B, Nygaard I E et al., "Effects of estrogen with and without progestin on urinary incontinence", JAMA 2005 293 8 ; : pp. 935948. 78. Reitz A, Stohrer M, Kramer G et al., "European experience of 200 cases treated with botulinum A toxin injections into the detrusor muscle for urinary incontinence due to neurogenic detrusor overactivity", Eur. Urol. 2004 45 4 ; : pp. 510515. 79. Abdelmalak J B, Rackley R R, Vasavada S P et al., "Botulinum A toxin botox ; injection for the treatment of refractory overactive bladder", poster presented at the American Urogynecological Society 2004 Scientific Meeting 2931 July 2004 ; , San Diego, California. 80. Appell R A, Sand P Dmochowski R et al., for the OBJECT Study Group, "Prospective randomized controlled trial of extended, release oxybutynin chloride and tolterodine tartrate in the treatment of overactive bladder: results of the OBJECT Study", Mayo Clin. Proc. 2001 76: pp. 358363 and dilantin.
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Stepwise differentiation of CD4 memory T cells defined by expression of CCR7 and CD27 Fritsch R.D., Shen X., Sims G.P., et al.; J. Immunol. 175 10 6489-6497 ; , 2005 [Dr. P.E. Lipsky, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Building 10, Bethesda, MD 20892, United States] Claassen E.A.W., Van Der Kant P.A.A., Rychnavska Z.S., et al.; J. Immunol. 175 10 6597-6604 ; , 2005 [Dr. E.A.W. Claassen, Animal Sciences Group, Wageningen University and Research Center, P.O. Box 65, 8200 AB Lelystad, Netherlands] Wei C.- H., Trenney R., Sanchez- Alavez M., et al.; J. Immunol. 175 10 6615-6623 ; , 2005 [Dr. L.A. Sherman, Department of Immunology, IMM- 15, Scripps Research Institute, 10550 North Torrey Pines Road, San Diego, CA 92037, United States] Sengupta S., Chilton P.M., Mitchell T.C.; Immunobiology 210 9 647-659 ; , 2005 [T.C. Mitchell, Institute for Cellular Therapeutics, University of Louisville School of Medicine, Louisville, KY 40202, United States] Hellwig S., Schamel W.W.A., Pflugfelder U., et al.; Immunobiology 210 9 685-694 ; , 2005 [H.U. Weltzien, MaxPlanck- Institute for Immunobiology, St beweg 51, D- 79108 u Freiburg, Germany] Tamauchi H., Yoshida Y., Sato T., et al.; Immunobiology 210 9 709-721 ; , 2005 [H. Tamauchi, Department of Microbiology, Kitasato University School of Medicine, Sagamihara 228- 8555 Kanagawa, Japan] Chuang Y.- H., Lian Z.- X., Cheng C.- M., et al.; J. Autoimmun. 25 2 126-132 ; , 2005 [M.E. Gershwin, Division of Rheumatology, Allergy and Clinical Immunology, University of California, Davis School of Medicine, 451 E. Health Sciences Drive, Davis, CA 95616, United States] and diovan.
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Synopsis A commentary in the current edition of the Archives of Internal Medicine notes that although ALLHAT appears to have settled the debate about the benefits or risks of diuretics in the management of hypertension, the more recent publication of the Second Australian National Blood Pressure Study ANBP-2 ; appears to have reopened the discussion. This article aims to put ANBP-2 and ALLHAT in perspective and review some of the repeated arguments against the use of diuretics as initial therapy. ALLHAT found that diuretics were clearly as effective as other medications in lowering BP and reducing CV events. ANBP-2, an un-blinded study in over 6000 mainly white patients, compared the outcome results of an ACEI with a diuretic-based treatment regimen. It reported a marginally significant P 0.05 ; difference in CV events in favour of the ACEI cohort, which was seen only in men, a finding that was difficult to explain. The ANBP-2 results have set off a major debate with heated discussions about the defects of ALLHAT and backand-forth arguments regarding the relative benefits of ACEIs and diuretics. The article points out that both classes of medications are highly effective in lowering BP and reducing CV events; ALLHAT clarifies the role of diuretics in therapy and ANBP-2 results do not negate the results of ALLHAT. It goes on to say that although cost should not be the major reason for selecting one medication over another, if 2 treatments are equally effective, then the less expensive option should be chosen. The article reiterates that fewer than 50% of all patients will achieve goal BP with diuretics as monotherapy so most hypertensive patients, especially those with diabetes or evidence of renal disease, will require medications in addition to a diuretic to achieve normotensive BP levels, for instance, dwtrol doctor effects side.
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37. Ability to use online analytical processing tools 38. Ability to understand a solid design and implementation methodology Spiral Methodology ; 39. Ability to document security integrity 40. Ability to articulate and flow chart how data integrity will be maintained 41. Knowledge of the most common large-scale database software programs Oracle, Sybase, Informix, Microsoft SQL, Pervasive SQL ; 42. Ability to creatively solve problems 43. Knowledge of computer programming 44. Knowledge of how medical charges are billed 45. Ability to listen to and understand user requests 46. Knowledge of proper customer service 47. Exposure to existing commercial clinical database systems 48. Experience interfacing databases with Web pages 49. Ability to work as a member of database design team.
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Synopsis Initial research on a drug called caffeinol, consisting of a mixture of caffeine and ethanol ; , has found that it may reduce the amount of damage caused by strokes. Investigators from the University of Texas Houston Medical School gave caffeinol to 23 male and female stoke patients with an average age of 71. It was found that the amount of brain damage was reduced by up to 80% if caffeinol was given within three hours. According to BBC news, the investigators also found that caffeinol could be safely given with thrombolytic drugs. A professor in stroke medicine at University College London told BBC news that although the results were good caution is required. He added that although at present it is not known how caffeinol exerts it's effects, alcohol does have the effect of opening up blood vessels and caffeine, which is beneficial in conditions like migraine, could improve blood flow. The lead investigator in the study told BBC news that further research would be required in the area in the form of clinical trials and in the future the team hope to also look at whether combining caffeinol with cooling treatments would provide further benefits. The study is published in the April edition of the journal Stroke: Journal of the American Heart Association.
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Diagnostic and therapeutic utility of radioiodinated meta-iodobenzylguanidine MIBG ; : 5 years experience. Ear J Nuc- ed 1990; 16: 325-31. M 3. Farahati J. Dutschka K, Stuben G. et al. The effect of specific activity on I-123-MIBG uptake in SK-N-SH tumor cells in a xenograft nude mouse model. Ear J Nuc-Med 1995: 22: 829. Dae MW, O'Connell JW. Botwinick EH. et al. Scintigraphic assessment of regional cardiac adrenergic innervation. Circulation 1989: 79: 634-644. Farahati J, Wertulla I. Wehr M. Reiners CH. as a marker of sympathetic innervation after myocardia! infarction. Nuklearmedizin 1992: 15: 195-201. MnchG. Ziegler S, Nguyen N. Hartmann F, Watzlowik P. Schwaiger M. Scinti graphic evaluation of cardiac autonomie innervation. J Nuc- ordial 1996: 3: 265-277. C 7. Wieland DE. Brown LE. Rogers Wl, et al. Myocardial imaging with radioiodinated norepinephrine storage analog. J Nuc- ed 1981: 22: 22-31. M 8. Mock BH. Tuli MM. Influence of specific activity of myocardial uptake of 1-123M1BG in rats. Nuc- ed Commun 1988; 9: 663-7. M 9. Vaidyanathan G, Zalutsky MR. No-carrier-added meta-iodo-benzylguanideine: syn thesis and preliminary evaluation. Nuc- ed Biol 1995: 22: 61-64. M 10. Mairs RJ. Cunningham SH. Russell J. et al. No-carrier-added I-131-MIBG: evaluation of a therapeutic preparation. J Nuc- ed 1995: 36: 1088-1095. M 11. Wieland DM. Wu JI, Brown LE. Mangner TJ, Swanson DP, Beierwaltes WH. Radiolabeled adrenergic neuron-blocking agents: adrenomedullary imaging with I-131-iodobenzylguanidine. J Nuc- ed 1980: 21: 349-353. M 12. Dutschka K, Coenen HH. UngetrgerteRadiosynthese von Meta-['21i]Iodobenzylguanidin und 3 3- 4-[123i]-Iod-Phenyl ; Tropan-2Y-Carbonsure Methylesther durch Nicht Isotopen, Cu l -assistierten Halogenaustausch [Abstract]. Nuklearmedi: in 1994; 33: All. 13. Heyns AD. Ltter MG. Badenhorst PN. et al. Kinetics, distribution and sites of destruction of In-111-labeled human platelets. Br J Haemalol 1980: 44: 269-280. Stabin M. Personal computer software for internal dose assessment in nuclear medicine. J Nuc- ed 1996: 37: 538-546. M 15. Schoenmakers C, Pigmans IGAJ, Visser TJ. Species differences in liver type I iodothyronine deiodinase. Biochim Biophvs Acta 1992: 1121: 160-166. Toyoda N, Hamey JW, Berry MJ. Larsen PR. Identification of critical amino acids for 3, 5, 3'-triiodthyronine deiodination by human type I deiodinase based on comparative functional-structural 1994: 32: 20329-34. analyses of the human, dog and rat enzymes. J Biol Chem and flovent.
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Fluctuations in the demand for products, the success and timing of collaboration arrangements and regulatory approval, any termination of development efforts will cause fluctuations in our quarterly operating results, which could cause volatility in our stock price. Our quarterly operating results are likely to fluctuate significantly, which could cause our stock price to be volatile. These fluctuations will depend on many factors, including: timing of product sales and market penetration; timing of operating expenses, including selling and marketing expenses and the costs of expanding and maintaining a direct sales force; success and timing of regulatory filings and approvals for products developed by us or our licensing partners or for collaborative agreements; timing of product launch; introduction of competitive products into the market; results of clinical trials with respect to products under development; the initiation of litigation against us, or adverse developments in any judicial proceedings in which we are involved; a change in the perception of the health care and or investor communities with respect to our products; success and timing of collaboration agreements for development of our pharmaceutical candidates and development costs for those pharmaceuticals; timing of receipt of upfront, milestone or royalty payments under collaboration agreements; termination of development efforts of any product under development or any collaboration agreement; and timing of expenses we may incur with respect to any license or acquisitions of products or technologies. We have various mechanisms in place to discourage takeover attempts, which may reduce or eliminate our stockholders' ability to sell their shares for a premium in a change of control transaction. Various provisions of our certificate of incorporation and by-laws and of Delaware corporate law may discourage, delay or prevent a change in control or takeover attempt of our company by a third party that is opposed by our management and board of directors. Public stockholders who might desire to participate in such a transaction may not have the opportunity to do so. These anti-takeover provisions could substantially impede the ability of public stockholders to benefit from a change of control or change in our management and board of directors. These provisions include: preferred stock that could be issued by our board of directors to make it more difficult for a third party to acquire, or to discourage a third party from acquiring, a majority of our outstanding voting stock; classification of our directors into three classes with respect to the time for which they hold office; non-cumulative voting for directors; control by our board of directors of the size of our board of directors; limitations on the ability of stockholders to call special meetings of stockholders; 21.
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