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Kurzweilai articles art0462 Ray Kurzweil and Gregory Stock, Director, UCLA Program on Medicine, Technology and Society, debated "BioFuture vs. MachineFuture" at the Foresight Senior Associate Gathering, April 27, 2002. This is Ray Kurzweil's presentation. Published on KurzweilAI May 1, 2002. Audio clips of the debate.
ISMP. 2003 ; . Recurring confusion between opium tincture and paregoric. ISMP Medication Safety Alert! Community Ambulatory Edition, 4, 1-2. ISMP. 2003 ; . Recurring confusion between opium tincture and paregoric. ISMP Medication Safety Alert! Community Ambulatory Edition, 4, 1-2, for example, fluticasone mechanism of action.
Asthma topics include: medications, how to use your inhaler, prevention, and more.
VIVA Medicare Plus RX Part D Drugs Requiring Prior Authorization or Quanity Limit Summary List As of April 2007 This is a list of prescription drugs that either require prior authorization, have quanity limits or are excluded from coverage. This is not an all inclusive list. It is provided strictly as a guide and may change periodically. With the uncertainty of Part D vs. Part B coverage, most Biological, Biotechnicals and Speciality medications require prior authorizations. Please call VIVA Health Medical Management at 933-1201 in Birmingham or 1-800-294-7780 if you have questions regarding a particular drug. Pharmaceuticals Adderall XR, Ritalin, Concerta, Cylert, Metadate, dextroamphetamine, Strattera, methylphenidate, Methylin, Dextrostat, amphetamine Advair, Asmanex, Azmacort, Flovent HFA, Flunisolide, Nasacort AQ, Nasarel, Nasonex, Pulmicort, Qvar, Rhinocort Aqua, fluticasone spray QL ; Accuneb, Albuterol, Combivent, Foradil, Maxair, Proventil, Serevent, Xopenex, Proair QL ; Alinia QL ; Ambien, Lunesta, Sonata QL ; * Androderm, Androgel, Testim, Depo-testosterone, testosterone cypionate Astelin QL ; Atrovent Inhaler, Atrovent, Combivent, ipratropium soln, Spiriva QL ; Celebrex cromolyn soln, Intal, Tilade QL ; Exjade Elidel, Protopic Emend QL ; Frova, Imitrex, Maxalt, Relpax, Zomig, Migranal QL ; * gabapentin QL ; Kytril QL ; Lamisil, itraconazole, Sporanox leflunomide Lyrica QL ; Marinol QL ; * Neurontin QL ; Nexium, Prevacid, Prilosec, omeprazole, Prevpac, Zegerid, QL ; * Provigil Ranexa Regranex Retin-A, Retin-A Micro, Differin, tretinoin Revatio Soriatane, Raptiva Tamiflu QL ; Zofran QL ; * Part D Biological, Biotechnical, & Specialiy Drugs * * some of these medications can be covered by Part D or Part B, depending on their diagnosis or setting. Please contact VIVA Health Medical management for more information. Actimmune Aranesp Enbrel Epogen not chemo related ; Forteo Genotropin Humatrope Humira Infergen Intron A Neulasta Neupogen Norditropin Nutropin Nutropin AQ Octreotide Pegasys Peg-Intron Procrit not chemo related ; Rebetol Rebetron Remicaid Ribasphere Ribavirin Roferon-A Saizen Sandostatin Sandostatin Lar Somavert Thalomid Xolair.
The combination of fluticasone advair ; and salmeterol advair ; comes as a powder to inhale by mouth using a special inhaler device.
1998; 80 4 ; : 295-30 busse w, wolfe j, storms w, et al fluticasone propionate compared with zafirlukast in controlling persistent asthma: a randomized double-blind, placebo-controlled trial and advil.
Howard Steinberg, M.D. Mary Taylor: Senior Director Worldwide Regulatory Affairs, WarnerLambert Parke-Davis Research and Development Robert Thompson, M.D.: Senior Director Medical Research Silve Tomsic, M.D.: Medical Physician, Safety Group, Warner-Lambert Dr. Paul Watkins: Consultant Howard Weisman: Marketing, Warner-Lambert Randall Whitcomb: Vice President Global Project Management at Pfizer Global Research and Development J.Wright Witcher: Vice President of Marketing Warner Lambert Dr. Robert Zerbe: Warner-Lambert Senior vice President of Worldwide Clinical Research.
Releases and Transfers by Chemical Substances and Table 2-2. The chemicals with reduction of releases and transfers were asbestos -1.3 ktons ; , arsenic and its inorganic compounds -0.68 ktons ; , HCFC-142b -0.61 ktons ; , benzene -0.46 ktons ; and barium and its water-soluble compounds -0.41 ktons ; etc., 123 chemicals in total. The total reduction of these chemicals was 7.7 ktons. On the other hand, the chemicals with increase of releases and transfers were ethylene glycol 7.6 ktons ; , chromium and chromium ; compounds 4.0 ktons ; , ethylbenzene 3.7 ktons ; , manganese and its compounds 3.6 ktons ; and N, N-dimethylformamide 2.1 ktons ; etc., 201 chemicals in total. increases of these chemicals were 38 ktons. Asbestos had been widely used for building materials. human health. However the changes to the alternative materials have proceeded, because of the issue of its concern to the So the amount of its use is supposed to decrease. The main reason of the decrease of arsenic and its inorganic compounds is due to the decrease of landfills of the sludge from the process of refining an ore containing these chemicals in Metal Mining industry. Releases and transfers of HCFC-142b reduced by 45% from 1.3 ktons for 2002 to 0.74 ktons for 2003. One of the reasons for the reduction is supposed to be that the Benzene is a changes to the alternative materials are proceeding for the use of foaming agent. The reduction of benzene was mainly due to the air emission. nominated as a Substance Requiring Priority Action. substance designated as a hazardous air pollutant in Air Pollution Control Law and As a matter of course, there is an emission criterion for benzene as a designated substance of Air Pollution Control Law, while voluntary management plans of the industries for benzene are ongoing in the program of Industry Associations. reasons of the reduction of air emission of benzene. For barium and its water-soluble compounds, 63% of this substance were reported from the industry of Ceramics, Stone and Clay Products and it is supposed to be used mainly for glass. The decrease of releases and transfers of this substance was mainly due to the decrease of transfers as waste. Ethylene glycol is a main component of the coolant of the automobile engines. Automobile Maintenance Services extract the coolant, and then transfers the used These are supposed to be the The total and theophylline, for instance, inhaled fluticasone.
Important Safety Information Kaletra should not be given to patients who have had an allergic reaction to the active substances or any of the excipients, or by patients with severe hepatic insufficiency. Kaletra is contraindicated with astemizole, terfenadine, midazolam, triazolam, cisapride, pimozide, amiodarone, ergot alkaloids e.g., ergotamine, dihydroergotamine, ergonovine and methylergonovine ; , products containing St. John's wort Hypericum perforatum ; and vardenafil. Kaletra should not be co-administered with lovastatin, simvastatin, rifampicin, fluticasone or other glucocorticoids. Co-administration of efavirenz, nevirapine, nelfinavir or amprenavir with Kaletra tablets 400 100 mg is not recommended. If co-administration of these products with Kaletra is clinically indicated, a dose increase of Kaletra tablets to 600 150 mg twice daily may be considered. However, as the safety of high doses of Kaletra has not been established, safety should be closely monitored when Kaletra tablets 600 150 mg twice daily is administered. Particular caution must be used when prescribing sildenafil or tadalafil in patients receiving Kaletra. Concomitant use of Kaletra with tadalafil or sildenafil is expected to substantially increase PDE5 inhibitor associated adverse reactions including hypotension, syncope, visual changes and prolonged erection. Particular caution must be used when prescribing Kaletra and medicinal products known to induce QT interval prolongation such as chlorpheniramine, quinidine, erythromycin, or clarithromycin. Levels of ethinyl estradiol may decrease when estrogen-based oral contraceptives are coadministered with Kaletra; alternative or additional contraceptive measures are to be used. Please consult your local prescribing information for any additional country specific prescribing recommendations. Cases of pancreatitis have been reported in patients receiving Kaletra, including those who developed hypertriglyceridemia. Kaletra is contraindicated in patients with severe liver impairment. Patients with chronic hepatitis B or C and treated with combination antiretroviral therapy are at an increased risk for severe and potentially fatal hepatic adverse events. Patients should be monitored, and if there is evidence of worsening liver disease in such patients, interruption or discontinuation of treatment should be considered. In patients receiving protease inhibitors, increased bleeding in patients with hemophilia ; , new onset or exacerbation of diabetes mellitus and hyperglycemia have been reported.
This emedtv resource explains that fluticasone hfa is used for preventing asthma attacks and albenza!
Tamiflu patients and 225, 000 influenza patients who did not receive the drug. Additionally, data from a Japanese Ministry of Health, Labor and Welfare study during the 2005 2006 influenza season reported no increase in neuropsychiatric events in Tamiflu patients vs. influenza patients not receiving Tamiflu. Last year, ROG updated Tamiflu's label to include postmarketing reports of self-injury and delirium in patients treated with the influenza drug. The label notes that the reports, mostly from Japan, were primarily among pediatric patients and that the contribution of Tamiflu to these events is not known. GlaxoSmithKline plc LSE: GSK; GSK ; , London, U.K. Product: Advair Diskus salmeterol fluticasone propionate Business: Pulmonary Molecular target: Adrenergic receptor alpha 2 ADRA2 ; Description: Adrenergic receptor alpha 2 agonist and corticosteroid Indication: Treat chronic obstructive pulmonary disease COPD ; Endpoint: Proportion of patients who experienced an exacerbation of COPD that required treatment with systemic steroids or antibiotics; mean number of exacerbations per patient-year, number of hospitalizations for COPD, total number of hospitalizations, quality of life, dyspnea and lung function Status: Post-marketing study data Milestone: NA Data from a double-blind, placebo-controlled, Canadian postmarketing study of 449 patients with moderate to severe COPD showed that Advair Diskus plus Spiriva tiotropium did not significantly reduce the number of COPD exacerbations compared with Spiriva plus placebo. Treatment with Advair Diskus plus Spiriva did improve lung function p 0.049 ; and disease-specific quality of life vs. placebo arm p 0.01 ; . GSK markets Advair for asthma and COPD and Serevent for asthma, while Pfizer Inc. PFE; New York, N.Y. ; and Boehringer Ingelheim GmbH Ingelheim, Germany ; market Spiriva for COPD. Data were published in the Annals of Internal Medicine. GPC Biotech AG FSE: GPC; GPCB ; , Munich, Germany Pharmion Corp. PHRM ; , Boulder, Colo. Spectrum Pharmaceuticals Inc. SPPI ; , Irvine, Calif. Product: Satraplatin Business: Cancer Molecular target: DNA Description: Platinum compound Indication: Treat hormone-refractory prostate cancer HRPC ; Endpoint: Progression-free survival; overall survival and time to pain progression Status: Additional Phase III data Milestone: Submit MAA 2Q07 ; Additional data from the double-blind, international Phase III SPARC trial in 950 patients showed that satraplatin plus prednisone led to pain response rates of 24.2% vs. 13.8% with placebo plus prednisone p 0.005 ; . Patients in the satraplatin arm also experienced prostate specific antigen PSA ; response rates of 25.4% vs. 12.4% with placebo p 0.001 ; . Pain response was assessed using a weekly present pain intensity PPI ; score as defined by the McGill-Melzack questionnaire. Data were presented at the European Association of Urology meeting in Berlin. Satraplatin has Fast Track designation and is under review in the U.S. GPC in-licensed the compound from SPPI in 2002. PHRM has European marketing rights. Last year, the partners reported that the trial met the primary endpoint of a significant improvement in progression-free survival see BioCentury, Oct. 2, 2006 ; . See next page!
May cause drowsiness, dizziness, or impaired judgment with first doses use caution when driving or engaging in tasks that require alertness until response to drug is known postural hypotension use caution when rising from sitting or lying position or when climbing stairs nausea frequent mouth care or sucking lozenges may help urinary incontinence void before taking medication ejaculatory disturbance reversible, may resolve with continued use of drug diarrhea buttermilk, boiled milk, or yogurt may help palpitations or rapid heartbeat; respiratory difficulty, unusual cough, or sore throat; or other persistent side effects and albendazole.
Division of Endocrinology and the Koret Center for Human Nutrition, San Francisco General Hospital K.M., M.K.H., M.S. the Metabolism Section, Medical Service, Department of Veterans Affairs Medical Center C.G. the Department of Medicine, University of California K.M., C.G., M.K.H., R.A.N., M.S. ; , San Francisco, California 94143; and the Department of Nutritional Sciences, University of California K.M., M.K.H., R.A. NJ, Berkeley, California 94720.
Symposia sponsored by GlaxoSmithKline at the congress, which provided important new data contributing to improvements in patient care in asthma and chronic obstructive pulmonary disease COPD ; . During the symposium entitled `The evolution of asthma management: Are we achieving optimal control?' new findings from the pivotal Gaining Optimal Asthma Control GOAL ; study and benefits gained by patients were presented. Insights and recent clinical data using the Asthma Control TestTM ACT ; , a new validated tool for measuring asthma control, were also discussed. The symposium `Affecting the mortality in COPD: Is the dream becoming a reality?' raised and discussed the important question, `can we help COPD patients feel better and live longer?' The landmark study TOwards a Revolution in COPD Health TORCH ; , has assessed all-cause mortality in patients with COPD receiving a fixed combination of salmeterol and fluticasone propionate SeretideTM ; over three years. The results from this trial have important implications for the way we treat COPD patients and spironolactone!
Significant reduction in sputum eosinophils only in the montelukast group implies that the effect seen in peripheral blood also relates to anti-inflammatory changes in the lung. The absence of tolerance with montelukast in long term treatment may also be an advantage.8 19 Safety and tolerability--Both montelukast added to fluticasone and salmeterol added to fluticasone were generally well tolerated, with slightly more drug related and serious events in the salmeterol-fluticasone group compared with the montelukast-fluticasone group. Conclusion The results of this study imply that the addition of montelukast in patients whose symptoms remain uncontrolled with inhaled fluticasone could be as effective as adding salmeterol in protecting against asthma exacerbations.
21 mcg salmeterol and 45, 115 or 230 mcg fluticasone per inhalation 90 mcg per inhalation 2.5 mg in 3 mL unit-dose vials 65 mcg per inhalation 500 mcg in 2.5 mL unitdose vials 21 mcg per inhalation and glimepiride.
It's a combination of flovent and servent fluticasone and salmeterol.
Esidrix hydrochlorothiazide ; Eskalith lithium carbonate ; Estrace estradiol ; Estratest esterified estrogens with methyltestosterone ; Estratest H.S. esterified estrogens with methyltestosterone ; Estring estradiol vaginal ring ; Estrogel estradiol gel ; Ethyol amifostine ; Etopophos etoposide phosphate ; Etoposide etoposide ; Evista raloxifene ; Exelon rivastigmine ; Exjade deferasirox ; Exubera insulin human [rdna origin] ; Eyescrub Pre-moistened Pads eye scrub ; Fabrazyme agalsidase beta ; Famvir famiciclovir ; Fareston toremifene ; Faslodex fulvestrant ; Feiba VH coagulant complex inhibitor ; Felbatol felbamate ; Feldene piroxicam ; Femara letrozole ; Fentora fentanyl buccal ; Ferrlecit sodium ferric gluconate complex ; Flagyl 375 metronidazole ; Flarex fluorometholone ; Flexeril cyclobenzaprine ; Flomax tamsulosin ; Flonase fluticasoone propionate ; Flovent fluticssone propionate ; Flovent HFA fluticasonee propionate ; Floxin ofloxacin ; Fludara fludarabine ; Fludarabine fludarabine ; Focalin dexmethyiphenidate hcl ; Focalin XR dexmethyiphenidate hcl ; Folgard foltab-800 ; Folgard Rx folic acid ; Folvite folic acid ; Foradil formoterol fumerate inhalation powder ; Fortaz ceftazidime ; Forteo teriparatide rdna origin ; injection ; Fosamax alendronate sodium ; Fosamax + D alendronate sodium ; Fosrenol lanthanum carbonate ; Fototar coal tar ; Fragmin dalteparin sodium ; FreeStyle Flash Meter glucose meter ; FreeStyle Meter glucose meter ; Frova frovatriptan succinate ; Fuzeon T-20 enfuvirtide ; Gabitril tiagabine ; Galzin zinc salts ; Gammagard immune globulin intravenous human Gardasil quadrivalent human papillomavirus ; Gemzar gemcitabine ; Gengraf cyclosporine ; Genotropin somatropin ; Genotropin Miniquick growth hormone with somatropin ; GentleEase LIPIL formulas- infant and anacin.
Etoposide .13 EURAX.41 EVISTA.29 EVOXAC .32 EXELON.19 EXJADE .25, 33 FABRAZYME.27 famotidine .30 famotidine inj .30 FAMVIR .10 FARESTON.11 FASLODEX.11 FAZACLO.21 FELBATOL.19 felodipine ext-rel.17 FEMARA.11 fenofibrate.16 fentanyl transdermal.5 fexofenadine .36 finasteride .32 flecainide.15 FLOMAX .32 FLOVENT HFA.38 FLOXIN OTIC .43 floxuridine .12 fluconazole .8 fluconazole inj .8 FLUDARABINE PHOSPHATE.13 fludrocortisone.28 flunisolide spray.37 fluocinolone acetonide crm, oint 0.025%.40 fluocinolone acetonide soln 0.01%.40 fluocinonide crm, gel, oint, soln 0.05%.40 fluoride drops .35 fluoride tabs .35 fluorometholone.42 FLUOROPLEX 1%.39 fluorouracil .12 fluorouracil soln 2%, 5%.39 fluoxetine .20 fluphenazine .21 fluphenazine decanoate inj .21 fluphenazine HCl inj .21 flutamide.11 fluticasone propionate crm 0.05%, oint 0.005%.40 fluticasone spray.37 fluvoxamine.18 FML oint .42 49.
Ince its approval by the United States Food and Drug Administration in 1985, the implantable cardioverterdefibrillator ICD ; has supplanted antiarrhythmic drug therapy as the standard of care for patients with potentially lethal ventricular dysrhythmias. This trend has resulted largely from improvements in the safety and tolerability of the device, compared to adverse drug responses associated with commonly employed medications. As ICD indications have broadened, and the number of patients receiving the device has dramatically increased, more attention has been directed to the specific sequelae of its use. The authors reviewed the literature on the quality of life and psychiatric symptoms created or revealed in the population of patients receiving ICD implantation. Although relatively scant, the literature consistently revealed a host of psychiatric disturbances that affect up to 87% of ICD recipients. Depressive and anxious symptoms predominate, with as many as 38% of patients experiencing anxiety sufficient to meet formal diagnostic criteria for an anxiety disorder. In the absence of information about premorbid anxiety disorders in this population, psychological theories such as classical and operant conditioning, learned helplessness, and distorted cognitive appraisal have been proposed to assist in conceptualizing new-onset anxiety disorders in this specific and panadol.
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Table 2 fixed-dose combination benefits and acetaminophen and fluticasone, for example, fluticasone cream bp.
LACK OF EFFECT OF FLUTICASONE PROPIONATE AQUEOUS NASAL SPRAY ON THE HYPOTHALAMIC-PITUITARY-ADRENAL AXIS IN 2AND 3-YEAR-OLD PATIENTS Galant SP, Melamed IR, Nayak AS, et al. Pediatrics. 2003; 112: 96 Purpose of the Study. To determine the effects of fluticasone propionate FP ; 200 g daily ; on the hypothalamic-pituitary-adrenal HPA ; axis among patients 2 to 3 years of age. Study Population. Children 2 to 3 years of age who demonstrated positive skin test responses to 1 seasonal allergen and the presence of nasal symptoms for 1 hour daily on most days or the use of rhinitis medication on most days during the relevant allergen exposure season were studied. Methods. Children were administered FP 200 g daily ; N 33 ; or vehicle placebo N 32 ; for 6 weeks. Twelve-hour urine samples were collected, for determination of urinary cortisol levels, at the end of the 6-week treatment and at baseline. Routine chemical analyses, hematologic assessments, and electrolyte measurements were also performed at screening and at the last treatment visit. The secondary safety measures included the incidence of clinically significant alterations in laboratory test results, in the case of adverse effects. Results. There were no differences in urinary cortisol levels between the children who received FP and those who received placebo. The most common adverse events reported for either group were cough and fever. Vomiting was observed more frequently for the FP group 18% vs 3% ; , as was abdominal pain 12% vs 6% ; and epistaxis 6% vs 0% ; . However, there were no statistically significant differences in any of these findings. Conclusions. FP 200 g day ; was equivalent to placebo with respect to its effects on HPA axis function, as determined by 12-hour urinary free cortisol levels, among 2- to 3-year-old children. FP was otherwise well tolerated by these 2- to 3-year-old children with allergic rhinitis. Reviewer's Comments. At this juncture, FP nasal spray appears to be safe, in terms of HPA axis suppression, among young children. Christopher Randolph, MD Waterbury, CT.
A 42-year-old man with asthma has low-grade fevers, productive coughing, and mild exertional dyspnea. He denies chest pain or hemoptysis. Six weeks ago a persistent cough had developed with sputum production. His temperature had been as high as 38.2 C 100.6 F ; , and he had expectorated thick brown cords in the phlegm. The patient was given a diagnosis of pneumonia and received a course of azithromycin without benefit. The patient has had asthma since childhood. His only medications are inhaled fluticasone 440 g a day and albuterol as needed. He does not smoke cigarettes but he does smoke marijuana. The peripheral leukocyte count is 11, 200 L with 35% eosinophils. The chest radiograph shows diffuse pulmonary infiltrates. What is the most likely diagnosis? and anafranil.
Guideline-defined control can be achieved and maintained. More patients achieved both totally controlled and well-controlled asthma with combination inhaled salmeterol fluticasone more rapidly and at a lower dose of corticosteroid than with inhaled fluticasone alone. Patients that achieved control recorded very low rates of exacerbations and near-maximal health status scores. Furthermore, in stepping up treatment in an attempt to achieve guideline-defined total control, even those patients who did not attain our stringent definitions of control showed considerable improvements in health status and a reduction in exacerbation rates. The overall AQLQ score for all groups and strata approached or surpassed the value of 6, suggesting that asthma no longer had a significant impact on quality of life, and AQLQ scores were higher for salmeterol fluticasone than for fluticasone 10, 28 ; . A greater degree of improvement was also seen in lung function; morning FEV1 improved to within a range considered normal. The absence of a reference group prevents a formal assessment of the improvement in these measures, but compared with rates and measures recorded before study entry, the improvements appear substantial, with a consistent trend for further improvement in the maintenance dose phase. Because no widely accepted measures of asthma control were available, two composite measures from the Global Initiative for Asthma National Institutes of Health guideline goals of treatment were developed and proposed as targets for control. As single measures are likely to overestimate control, a composite measure was selected to assess the total impact of this disease on patients 9 ; . Totally controlled asthma was the complete absence of all features of asthma for at least 7 of 8 weeks. Well controlled was a pragmatic adaptation based on what is permitted by the guidelines as control, also sustained for at least 7 of 8 weeks. Such stringent and sustained measures of asthma control have never previously been assessed in a clinical trial. The results of our study suggest that total control should be the aim of treatment for all asthma patients. It is a realistic outcome for corticosteroid-naive patients, and although it may not be achieved by the majority of patients previously on moderate or high doses of inhaled corticosteroids, by stepping up treatment and aiming for total control of asthma, considerable benefits are achieved in almost all patients. This is particularly true for exacerbations, which were virtually eliminated in patients who achieved guideline-defined control either total control or well controlled ; . Because the focus of this study was to establish the proportion of patients with asthma that could achieve the target level of control, even if this took several months, the approach adopted was to continue treatment for the full duration of the trial and not step-down, as recommended in the guidelines. This also permitted evaluation of incremental benefit in secondary outcomes ; , both in those that reached this level and those that did not. During sustained treatment, a further 8 to 12% achieved totally controlled asthma, and further improvements in FEV1, exacerbation rates, and quality of life were observed, particularly in those that attained totally controlled asthma. This delayed realization of the full benefits of treatment may reflect a more gradual resolution of the airway inflammation with prolonged dosing 29, 30 ; . This effect is suggested by the results of the open-label phase in which relatively few patients benefited from the additional "maximum" treatment with 10 days of high-dose oral corticosteroid and 4 weeks of salmeterol fluticasone 50 500 g twice a day. Those who showed a response in this phase were predominantly patients who had not previously received salmeterol fluticasone. This finding suggests that the treatments and dosing approach had achieved as much as, or close to maximum benefit, at least as far as clinical total control is concerned. However, it must be recognized that some of the reasons for.
Laing R, Waning B, Gray A, Ford N, `t Hoen E. 25 years of the WHO essential medicines lists: progress and challenges. Lancet 2003; 361: 1723-1729. WHO Expert Committee on the Selection and Use of Essential Medicines. The Selection and Use of Essential Medicines. Geneva: World Health Organisation; 2002. WHO Technical Report Series 914. 6 WHO Expert Committee on the Selection and Use of Essential Medicines. The Selection and Use of Essential Medicines. Geneva: World Health Organisation; 2003. WHO Technical Report Series 920. p. 28. 7 Ibid. p. 26-30.
Generation of Allergen Specific T cell lines For Th2 lines, CD4 + T cells plus APC were cultured with 10g ml allergen and 10ng ml IL-4 plus neutralising antibodies to human IFN and IL-12 BD-Pharmingen, Abingdon, UK ; . For regulatory T cell lines, CD4 + T cells plus APC were cultured with 10g ml allergen, 10ng ml IL-4, 10-9M fluticasone proprionate and 10-6M salmeterol TFlut Sal ; . Both lines were cultured for 7 days, then restimulated at a 1: ratio with irradiated autologous APC under identical conditions as the original culture. The lines underwent 2 rounds of stimulation and then supernatants were harvested for cytokine analysis. To assay regulatory suppressive activity, cells were harvested at 14 days. Cultures contained the indicated combinations of 105 Th2 cells, 2.5x104 TFlut Sal line cells, 10g ml specific allergen, 5g ml anti-IL-10 receptor 3F9-2, DNAX, CA, USA ; or 5g ml control antibody R35-9S, BD-Pharmingen ; . All wells contained 105 irradiated autologous APC. On day 3 100l supernatant was removed for cytokine measurement.
In rare cases, inhaled steroids such as fluticasone have caused cataracts or increased pressure in the eye.
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Capabilities and products. Business The Company develops, manufactures and markets generic topical prescription pharmaceuticals at its New York and Yeruham, Israel facilities and non-topicals at its Michigan facilities. The Company focuses on topical generics, suppositories and unit dosages. The topical generics include creams, ointments, lotions, gels and solutions. The Company's current development areas include other delivery systems such as nasal sprays, foams and transdermal devices. Other areas of expertise include the production capabilities for various dosage forms such as tablets, capsules and semi-solid products. Pharmaceuticals are manufactured, labeled and packaged in facilities that comply with strict regulatory standards while also meeting customers' stringent requirements. The Company currently markets approximately 35 generic prescription products of various dosages. The Company holds the ANDA or NDA for the drugs that it manufactures. Listed below are the major products that the Company manufactures and or distributes: Generic Name Ammonium lactate cream and lotion Clindamycin phosphate solution Econazole nitrate cream Luticasone ointment and cream Halobetasol ointment and cream Ibuprofen oral suspension Ketoconazole shampoo Mesalamine rectal suspension enema Mometasone cream, ointment and lotion Mupirocin ointment Permethrin cream Selenium sulfide shampoo Competitive Brand Name Drug Lac Hydrin CleocinT Spectazole Cutivate Ultravate Motrin Nizoral Rowasa Elocon Bactroban Elimite Selsun.
To isolate patient populations that respond favorably to both medications, to one medication but not the other, and poorly to both medications. To examine whether the patient's asthma phenotype and genotype for selected markers can be linked to the response to inhaled fluticasone propionate and montelukast in this carefully characterized patient population.
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