Homas Starzl was born in Le Mars, Iowa, on March 11, 1926. His father was editor and publisher of the Globe Post and was a science fiction writer of some prominence. One of four children, Starzl became a newspaper carrier at age 12 and worked many jobs at the newspaper during his childhood years. Starzl was an excellent high school student and athlete. Upon graduation in 1944, he entered the naval officer's training school in Westminster College, Missouri. Upon discharge from the navy, he returned to the college and graduated from the premedical program with a degree in biology in 1947. Starzl entered Northwestern University Medical School that year and graduated in 1952 with both an MD and a Ph.D. degree. His work in developing a recording technique to track deep brain responses to sensory stimuli allowed him to earn the Ph.D. degree. For surgical training, Starzl was selected to the general surgery program at Johns Hopkins University Hospital. After completion, he became a staff surgeon at Jackson Memorial Hospital in Miami, Florida. In addition to his busy practice, Starzl set up a research laboratory in a garage in the hospital and began developing surgical techniques by which to remove livers from dogs. He returned to Northwestern in 1958 where he completed a thoracic surgery fellowship and subsequently joined the faculty. He received a National Institute of Health award funding experimental research into the techniques of liver.
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Marked contrast to activity of the hypaxial muscles during lung ventilation in these animals, in which only portions of four hypaxial muscles displayed activity Carrier, 1989 ; . Thus, the hypaxial muscles are locomotor muscles. Although the results support the hypothesis that the hypaxial muscles contribute to lateral bending of the trunk, the pattern of activity is not consistent with this function alone. The most obvious means of accomplishing lateral bending would be for one or more of the hypaxial muscles with longitudinal components to their orientation to be active on one side of the body while all those with longitudinal components on the other side are silent. However, in actuality, there is simultaneous activity on the two sides of the body, but in different muscles on either side. This suggests that the hypaxial muscles do more during locomotion than simply bend the body from side to side. Stabilization of the trunk during locomotion During walking and running, the propulsive force produced by the limbs can be divided into three components: vertical, horizontal and lateral Gray, 1968 ; . These three components also act in the opposite direction on the trunk, at the joint between the limb and girdle. The horizontal component is responsible for the forward motion of the animal and induces a rotational torque on the girdles Fig. 6A, B ; . The lateral component tends to bend the trunk at 90 to the desired direction of trayel, and also exerts a rotational torque on the girdles Fig. 6A ; . The vertical component, acting against gravity, induces long-axis torsion in the trunk Fig. 6C ; . If the animal is to move forward in an efficient manner, the trunk must be stabilized against these torques in a manner that allows transmission of the supportive and horizontal components to the centre of gravity. Stabilization of the girdles and vertebrae during locomotion could be accomplished solely by compressive elements i.e. bone ; or by tensile elements i.e. ligament ; . However, compressive or passive tensile struts would work only if they fixed the trunk in a rigid or almost rigid state, as in terrestrial arthropods. Alternatively, because muscles can act as tensile elements of variable length, they could stabilize the trunk and provide flexibility of movement as well. To accomplish this, the hypaxial muscles with longitudinal and oblique fibre orientations would have to be active in a predictable pattern Fig. 6 ; . The activity patterns of the hypaxial muscles of Iguana iguana are consistent with the hypothesis that they function to stabilize the trunk against the propulsive force. First, stabilization of the girdles against the horizontal and lateral components of the propulsive force requires that hypaxial muscles with fibres oriented longitudinally be active on the side of the trunk contralateral to hind support Fig. 6A ; . Activity of the rectus abdominis, the deep portion of the external oblique and the ventral portion of the internal intercostal match this prediction. Second, stabilization of the trunk against the vertical forces inducing long-axis torsion requires that hypaxial muscles with fibres oriented obliquely in ahe anterio-dorsal direction be active on the side of the trunk contralateral to hind "support Fig. 6C ; . The superficial portion of the external oblique and the external.
O-3: BIOSYNTHESIS OF THE HALLUCINOGENIC DITERPENOID SALVINORIN A PROCEEDS VIA THE DEOXYXYLULOSE PHOSPHATE PATHWAY Lukasz Kutrzeba1, Franck E. Dayan2, Jos-Luis Giner3, Jordan K. Zjawiony1, 4 1 Department of Pharmacognosy, School of Pharmacy, University of Mississippi, 2Natural Products Utilization Research Unit, University, MS 38677-1848, Agricultural Research Service, U.S. Department of Agriculture, University, MS 38677-8048, 3Department of Chemistry, State University of New York-ESF, Syracuse, NY 13210, 4National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677-1848 Salvinorin A, a neoclerodane diterpenoid, isolated from the Mexican hallucinogenic plant, Salvia divinorum is a potent kappa opioid receptor agonist. Its biosynthetic route was studied by NMR and HR-ESI-MS analysis of the products of the incorporation of [1-13C]-glucose, [Me-13C]-methionine, and [1-13C; 3, 4-2H2]-1-deoxy-D-xylulose into its structure. The use of cuttings and direct stem injection were unsuccessful, however, incorporation of 13C into salvinorin A was achieved using in vitro sterile culture of microshoots. NMR analysis of salvinorin A 2.7 mg ; isolated from 200 microshoots grown in the presence of [1-13C]-glucose established that this pharmacologically important diterpene is biosynthesized via the 1-deoxy-D-xylulose-5-phosphate pathway, instead of the classic mevalonic acid pathway. This was confirmed in plants grown in the presence of [1-13C; 3, 42 H2]-1-deoxy-D-xylulose. In addition, analysis of salvinorin A produced by plants grown in the presence of [Me13 C]-methionine indicates that the methylation of the C-4 carboxyl group is catalyzed by a type III S-adenosyl-Lmethionine-dependent O-methyltransferase, because hyzaar blood pressure.
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Merck' s 2q profit rises 1 8 percent - jul 23, 2007 forbes, sales of the company' s top seller, asthma treatment singulair, rose 15 percent to $ 1 billion, but osteoporosis treatment fosamax saw sales dip 4 percent merck mrk ; beats earnings expectations on strong sales - jul 23, 2007 schaeffers research, digging deeper into the company' s report, we find that singulair sales jumped 15% to $ 1 billion, and sales of blood-pressure drugs cozaar and hyzaar rose codexis expands portfolio with biocatalytics buyout - jul 24, 2007 us-pharmatechnologist.
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Appendix Q: HHSC Selected Non-Medicaid Rate Methodologies TEXAS DEPARTMENT ON AGING TDoA ; No te: W hile the unit of service that is reimb ursed is consisten t across the state, the procurement me thodolo gy required b y the federal regula tions results in reimb ursemen t rate s being set a t the lo cal lev el. Type of Rate: Adult Day Care Agency: TDoA Program Description: An array of services provided in a congregate, non-residential setting to depende nt older persons who need supervision but do not need institutionalization. These services may include any combination of social or recreational activities, health maintenance, transportation, meals and other suppo rtive services. M ethodology: Unit of Service: A Half-Day. Three hours but less than six hours of service provided by the facility shall constitute one unit of service. Six hours or more of service shall constitute two units of service. Time spent for transportation to and from day care, if provided by the facility, is included in calculating the amount of service provided. Less than three hours of service at any one time is not considered to be a unit of service Rate Cycle: Septemb er 1 o each year. Type of Rate: Caregiver Resp ite Care In-Home Agency: TDoA Program Description: Tempo rary relief for care givers tha t include s an array of services p rovid ed to dependent older persons who need supervision. Services are provided in the client's home environment on a short-term, temporary basis while the prima ry caregiver is unavailab le or ne eds relief. In add ition to supervision, services may include meal preparation, housekeeping, assistance with personal care and or social and rec reational activities. M ethodology: Unit of Service: One Hour. Rate Cycle: Septemb er 1 o each year. Type of Rate: Congregate M eals and Home Delivered Meals Agency: TDoA Program Description: A hot or other appropriate meat served to an eligible person which meets one-third 1 3 ; of the recommended dietary allowances RDA ; as established by the Food and Nutrition Board of the National Academy of Sciences - National Research Council. There are two types of congregate and home delivered m eals as follows: Standard meal - the regular meal from the standard menu that is served to the majority or all of the participants. Therapeutic meal or liquid sup plement - a special meal or liquid sup plement that has been prescribed by a physician and is planned sp ecifically for the pa rticipant by a dietician, i.e., diabetic d iet, renal diet, pureed diet, tube feeding. Utilization: Approximately 4 million congregate meals and 4 million home delivered m eals pe r year. Provider Base: No statewid e databa se of providers. Area Agencies on Aging contract with local providers for service. Utilization: Approximately 33, 000 units per year. Provider Base: No statewid e databa se of providers. Area Agencies on Aging contract with local providers for service. Utilization: Approximately 20, 000 units per year. Provider Base: No statewid e databa se of providers. Area Agencies on Aging contract with local providers for service.
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