Workshop 8 Panel: Brave New LHINs Meeting Priority Needs of People Living With a SCI Moderator: Harley Nott, LLB, Board Director, Toronto Central Local Health Integration Network; Member of the Ontario Bar; Former Federal Crown Counsel Learning Objectives: 1. To understand the purpose, philosophy and process for establishing Ontario's new Local Health Integration Network and British Columbia's approach to meeting the health and long-term support needs of people living with a SCI 2. To describe real life barriers faced by people living with SCI in accessing timely, evidence-based health services and strategies to address their priority needs 3. To identify strategies for SCI consumers, service providers and researchers to influence the operation of LHINs to improve timely access to evidence-based services that meet the priority needs of people living with a SCI 15: 30 16: Plenary Presentation Research and the Consumer: How People Living with a SCI can Contribute to the Research Process and Drive Progress and Innovation Jaimie F. Borisoff, BSc in Engineering Physics, PhD in Neuroscience, Senior Researcher, Brain Interface Lab, Neil Squire Society and ICORD; President, Instinct Mobility Inc. Learning Objectives: 1. To inform consumers about the many ways they can become contributors to the research process and help drive progress and innovation 2. To illustrate how consumers themselves have become researchers and innovators 3. To inspire consumers to become engaged in the research process and illustrate how their contributions can make a difference 16: 30 17: 00 Closing Ceremonies.
The Baby Friendly Initiative UK The Baby Friendly Initiative UK continues to be a prime mover in relation to setting standards for maternity care - : babyfriendly UNICEF's Baby Friendly Initiative UK It's website lists the 42 hospitals which have achieved accreditation as Baby Friendly, either by the Global criteria 15 ; or by the UK standards 27 a further 52 maternity units hold a Certificate of Commitment. A seven-point plan covers the care provided by community health care facilities : babyfriendly commun #plan; 17 community healthcare facilities have either been designated as Baby Friendly 3 ; or have secured a Certificate of Commitment 14 ; . The Baby Friendly website also contains up-to-date information on the health benefits of breastfeeding and a list of past studies : babyfriendly health #allergic particularly in relation to atopic illness. Links to the following breastfeeding support organisations can also be made through their links page : babyfriendly links Breastfeeding Resources Department of Health The Department of Health website carries up-to-date information about the scheme planned to replace the Welfare Food Scheme : doh.gov healthystart . To be called `Healthy Start', it plans to reduce the possible disincentive to breastfeeding posed by milk tokens, to reduce the differential between tokens for formula relative to tokens for `doorstep' milk, and also make vegetables and cereals as alternative purchases under the welfare food token scheme. The Department has also issued new strategic objectives for the three year period 20032006 : doh.gov planning2003-2006 appb #8 ; , which includes those relating to reducing inequalities in health. The second of these relates to breastfeeding for which the target is to: * Deliver an increase of 2 percentage points per year in breastfeeding initiation rate, focussing especially on women from disadvantaged groups, for example, diuretics.
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January 2002 Dear Friends of Express Scripts: This is Express Scripts' third annual Top Developments on the Pharmaceutical Landscape report. Since our report of one year ago, we have again traveled some distance, and have experienced both imaginable and unimaginable events shaping the pharmaceutical landscape. One new component of this year's report is a "Perspectives" section, offering ideas on how developments of 2001 may impact the future. Once again, we have looked closely at the trends of the year past and identified those we believe most significantly define the path for managing the pharmacy benefit. Developments occurred throughout the year affected by the actions of the Food and Drug Administration FDA ; , the executive and legislative branches of the federal government and, most unexpectedly, terrorists determined to test the mettle of Americans. FDA approvals of new prescription drugs were down, but those drugs approved were increasingly sophisticated and came at a higher cost. The year passed without a Medicare prescription benefit, and President Bush's proposed prescription discount card has been stalled by a court injunction. Pharmaceutical companies, however, have begun offering their own discount cards. The withdrawal of several prominent drugs has taxed the FDA's drug-approval process. As envelopes bearing potentially deadly anthrax spores arrived on Capitol Hill, at office buildings and in postal facilities, people across the country turned to pharmaceuticals as an integral element of the nation's defense. I have mentioned only a few of the past year's most significant pharmaceutical developments, but in contemplating them all, one fact is overwhelmingly clear: enormous challenges lie ahead for pharmacy benefit sponsors, for those who hold responsibility for forging public policy and for consumers of prescription medications. In each case, awareness and knowledge provide the best tools for arriving at solutions. In that context, we invite you to explore with us the top pharmaceutical developments of 2001. Sincerely, for instance, altace.
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The various phenothiazines and other antipsychotic drugs differ from chlorpromazine, the ype drug, in potency, profile of action and incidence of side effects. Their relative efficacy atment of psychological disorder is not easy to assess. Studies have shown that no comis on the whole more effective than chlorpromazine and some are less so.
Your children are covered by your BCN Blue Elect SRO contract and also have coverage through their other parent's health care plan. Your spouse is employed and has coverage through his or her employer in addition to your BCN Blue Elect SRO coverage. Be sure to tell Blue Care Network if you or your family members are covered by more than one health care plan so that you get maximum coverage. If you receive a coordination of benefits questionnaire from Blue Care Network, please complete it and return it to us quickly as possible. If we don't receive your coordination of benefits information, we may not be able to process your claim. Whenever your other health insurance information changes, you can update our records by completing the form at the back of this book. The form is also available on our Web site. Fax the completed form to the attention of COB at 616 ; 285-5205. See Appendix B for a Coordination of Benefits form and isoflavone.
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On February 1, 2002 McFarland EMS became the first EMT Basic-IV Provider licensed by the State of Wisconsin. Congratulations to Jeff Dostalek, EMS Director and all of the McFarland Emergency Medical Technicians on providing their community with a higher level of emergency medical care.
The following inhibitors were purchased from Sigma St. Louis, MO ; and tested for inhibition of U. maydis growth: acriflavine Acr ; , benomyl Ben ; , chloramphenicol Chl ; , colchicine Col ; , cupric sulfate Cup ; , cycloheximide Cyc ; , ethidium bromide Eth ; , miconazole Mic ; , oligomycin Oli ; , valinomycin Val ; , and vinblastine Vib ; . Chloroneb Chb ; and vinclozolin Vin ; were purchased from Chem Service West Chester, PA ; . Cadmium chloride Cad ; was purchased from Fluka Chemika. Hygromycin Hyg ; was purchased from Calbiochem La Jolla, CA ; . Fenarimol Fen ; was a gift from Dow AgroSciences Indianapolis, IN ; . Chemicals were dissolved in the appropriate solvent Acr, Cad, Cup, Eth in dH 2O; Ben, Chb, Chl, Col, Cyc, Fen, Mic, Vib, Vin in dimethyl sulfoxide DMSO Val in chloroform; Oli in ethanol ; . The range of concentrations tested was as follows: 5, 10, 20 g Acr ml; 5, 10, 20, g Ben ml; 0.1, 0.5, 1, mM Cad; 25, 100, 200, g Chl ml; 1, 5, 10, g Chb ml; 5, 10, 25, g Col ml; 1, 5, 10, mM Cup; 0.1, 0.5, 1, g Cyc ml; 5, 10, 25, g Eth ml; 2, 4, 6, g Fen ml; 200, 300, 400 g Hyg ml; 1, 5, 10, g Mic ml; 1, 5, 25, g Oli ml; 100, 200 g Val ml; 1, 5, 10, g Vib ml; 2.5, 5, 10, g Vin ml. The different concentrations of each chemical were added to aliquots 3 ml ; of maydis cells prepared as described above. Each analysis included an untreated control that contained the solvent used to dissolve the inhibitor. Cells were incubated at 30C on a rotary shaker at 200 rpm and growth was evaluated by visual comparison over a period of 3 days. Sensitivity to high osmolarity was evaluated after growth for 3 days at 30C on PDA medium containing 1 M sorbitol or 1 M NaCl and vasodilan.
34. Regulations for the accountability or recordkeeping of controlled substances differ from the regulations for non-controlled medications. A. True B. False.
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How can it be that it is demonstrably far longer than seventeen years in some instances and significantly shorter in others? Regulatory review is not the exclusive answer to these questions. There are a multitude of patent and economic factors, largely under the discretion and control of the patent owner, which can dramatically affect the answer. The patent application filing date, patent issue date, and scope of a patent application are factors which may have an important effect on the length and scope of a commercial monopoly. This can be readily demonstrated by considering the following patent rules and practices: The patent law contains no requirement that a patentable idea be at any particular stage of development before a patent application may be filed. Obviously, if no patent application is filed until the invention is reasonably well along in the development process, it is likely that the inventor will enjoy a longer period of commercial exploitation. By waiting, the inventor runs a risk that others will file earlier patent applications on the same invention with the possible result that all patent protection will be denied and, worse yet, that someone else will possess a monopoly which will prevent the commercial practice of the invention. Not surprisingly, many patent applications are filed long before it is known if the inventions are commerically practical, solely as a defensive measure and without regard to any possible impact on the life of any subsequent commercial monopoly. It is perfectly permissible to file a patent application on a concept which has never been tested or which is far broader that the limited concept which has actually been tested. In pharmaceutical composition cases, for example, it is quite common to define the invention by a broad hypothetical chemical formula which encompasses hundreds or thousands of possible compounds having certain structural similarities, even though, at the time the original patent application is filed, only a small handful of compounds have actually been made and tested. The seventeen-year patent monopoly runs from the date on which the patent is actually granted, after it is examined by the United States Patent and Trademark Office, and does not run from the filing date of the patent application. How long a patent application remains pending in the Patent Office is highly variable and, to a significant extent, can be controlled by the inventor. It is entirely permissible to keep a patent application pending for a long time by abandoning the original patent application in favor of so-called continuation or continuation-in-part applications which supplement or expand upon the original invention disclosure, and which are based on work carried out by the inventor subsequent to the original application filing date. The use of this practice is widespread and has been common in pharmaceutical industry patents. By law, each patent must be limited to a single invention and, in many and ketorolac.
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Found less frequent use of sedatives in both genders and inhalants in girls 3 ; . The immediate risks connected with substance use include accidents, violence, risky sexual behavior, and exposure to human immunodeficiency virus HIV ; . The age when boys have their first contact with particular substances is constantly decreasing and is lower in the Primorsko goranska County than on the national level. The literature shows that the proportion of adolescents who smoke increases with age 3-6 ; . Also, adolescents who started smoking early are more likely to continue to smoke as adults. Even experimental smoking during adolescence increases the risk of adult smoking 2 ; . Addictive behavior is a major medical, psychological, and social problem, especially if we take into consideration the increasing consumption and availability of drugs 4 ; . The causation of substance use disorder is probably multifactorial but there has been increasing evidence suggesting that it has a neurological basis 7 ; . A number of factors has been consistently related to alcohol abuse among adolescents. They include gender, age, school grade, religious behavior, socioeconomic status, and involvement in extracurricular activities 8, 9 ; . Recent research has also addressed the connection between the likelihood of psychoactive substances abuse and certain psychological characteristics, psychopathological dimensions, motivation for illicit drug abuse and personal hierarchy of value 4 ; . Substance use, on the other hand, is more related to peer influence 10, 11 ; , relationship with parents 12-15 ; , and way of spending leisure time 16 ; . Another possible approach to assessing risk factors is the ecological perspective, which is concerned with contexts of daily life environments, influenced by the variation and interactions of personal and situational variables, which afford either risk or opportunity 17-21 ; . Although there are numerous studies describing the predictors of adolescent smoking 22-25 ; , only a few explored causation and tried to explain the nature of addictive behavior or possible predictive factors alone or together with other substances 3, 4, 26 ; . Development, implementation, and maintenance of accurate and reliable health riskbehavior information are essential for the effectiveness of prevention programs 27 ; . In our study and ketotifen.
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CUTANEOUS T-CELL LYMPHOMA CTCL ; The agents in development to treat CTCL that appear the most exciting are: BIOCRYST'S BCX-1777 a PNP inhibitor ; . Data from the Phase I dose escalation study were not presented at ASCO 2004, but an abstract has been accepted at American Society of Hematology ASH ; 2004. Dr. Madeleine Duvic of MD Anderson, probably the leading authority on cutaneous T-cell lymphoma CTCL ; , described this as "a small study, and the response rate was very tentative was mostly a PK study." She said the design of that Phase I study was: Patients got 9 infusions at the hospital, and then went home. "Response impact on the skin was measured not when it was happening in the hospital but when they came back to the doctor which was too late.The design was unfortunate.there was a clinical benefit, but the timing of the measurement was off.We did find that patients got enough drug to lower DGUO levels to a dose that was able to kill T-cells is and lamictal.
Carboximide fungicides Vinclozolin together with iprodione, chlozolinate, procymidone are dicarboximide fungicides with a different structure and mechanism of fungicidal action from the azolecontaining ergosterol biosynthesis inhibitors. They have been reported to have more or less potent anti-androgenic effects Gray et al. 1994; Gray et al. 1999; Kelce et al. 1997; Kelce et al. 1994; Ostby et al. 1999 ; , . Perinatal exposure to vinclozolin with doses ranging from 100 to as high as 400 mg kg day from gestational day 14 to postnatal day 3 ; induced nipple retention, cleft phallus, hypospadias, cleft phallus, occurrence of vaginal pouch, and atrophy of seminal vesicles and ventral prostate gland Gray et al. 1994; Wolf et al. 2000 ; . These effects are typical of that caused by flutamide, a known antiandrogen Imperato-McGinley et al. 1992 ; . Although several of the above effects could also be explained by inhibition of testosterone or dihydrotestosterone synthesis, the suite of effects caused by vinclozolin, differs from that of the known 5 -reductase inhibitor finasteride Imperato-McGinley et al. 1992 ; . Furthermore, inhibition of 5 -reductase was experimentally ruled out in a study by Kelce and coworkers Kelce et al. 1994 ; . In a recent study Sanderson et al. 2002 ; vinclozolin was identified as an inducer of aromatase activity and mRNA expression in H295R human adrenocortical cells. It is possible that vinclozolin may exert additional antiandrogenicity via aromatase induction if this mechanism were to occur in vivo. However, no studies with vinclozolin have so far been performed to examine this. Vinclozolin is not known to interact with the estrogen receptor or cause CYP17 inhibition, indicating that antagonism of the androgen receptor is its main mechanism of endocrine disruption.
Some patients receiving troglitazone. Despite cessation of therapy with the drug, a certain number of patients progress to liver failure because of acute hepatic necrosis. It is recommended that liver enzyme levels be monitored monthly during the first year of therapy and at least quarterly thereafter; if the alanine aminotransferase level exceeds 1.5 to 2 times normal, studies should be repeated in 1 week. Given the risks and benefits of the drug, troglitazone is no longer indicated as initial single-agent therapy. It should therefore be used only for insulin-dependent patients with type 2 diabetes whose condition is poorly controlled by other therapies and lamotrigine.
Synopsis A consultation is underway on extending the existing legislation on supplementary prescribing to chiropodists, physiotherapists, radiographers and optometrists. The deadline for comments is 9 August 2004. Over 1400 nurses have already qualified and registered as nurse supplementary prescribers. The first pharmacist supplementary prescribers qualified in February 2004, and around 100 pharmacists are registered as supplementary prescribers.
Bonnie Kimmel, MD, is a senior resident in general internal medicine at the Yale Primary Care Residency Program in Waterbury and New Haven, Conn. Silvio E. Inzucchi, MD, is a professor of medicine and clinical director of the Section of Endocrinology at Yale University School of Medicine and director of the Yale Diabetes Center at Yale-New Haven Hospital in New Haven, Conn. Note of disclosure: Dr. Inzucchi has served on advisory boards for Takeda, Pfizer, and Novartis. He has received honoraria for speaking engagements from Takeda, GlaxoSmithKline, and Bristol-Myers Squibb. These companies market oral pharmaceutical products for the treatment of diabetes and levothyroxine.
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Should I individualize workouts for an asthmatic? If so, how do I do this? No. It's okay to tailor the warm-up, but don't individualize the workout. Not only is it not practical you do not have the time ; , but the swimmer doesn't want special treatment either. The goal is to manage the asthma by managing the INTENSITY of the set. In fact, you can allow the swimmer to manage this intensity. He she still does the same set, but perhaps a little less intensely on days when triggers are prevalent. The best thing you can to do is OBSERVE, be aware, and know your athlete. Keep it simple. Eliminate the fear factor. What should I do if swimmer has an asthma attack? Should we have an Action Plan? Should the lifeguards be involved? First of all, do your homework. Talk to the parents of asthmatic swimmers in your group and find out what they do when it happens. In the event of an attack, know the general set of guidelines to follow. Keep calm, get the swimmer out of the water, and administer the rescue inhaler use the spacer! ; . When in doubt, call 911. Remove the swimmer from the "chaos, " monitor him her, and note improvements. * If your swimmer needs the rescue inhaler frequently, make sure he she meets with the healthcare provider and gets a written action plan for dealing with these attacks. Become familiar with it. What if my swimmer has an attack but doesn't have her medication with her? Don't let this happen. Ever. Let swimmers and parents know that the team rule is that asthmatics are responsible for having meds on hand at every practice. NO MEDS.NO SWIM. Consider including this announcement with registration materials. Run a reminder note in the team newsletter or on the team website. Also consider a policy that requires a minimum of a verbal release from the swimmer's legal guardian prior to returning to practice following an emergency episode.
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Ramesh, M. A., Laidlaw, R. D., Durrenberger, F., Orth, A. B., and Kronstad, J. W. 2001. The cAMP signal transduction pathway mediates resistance to dicarboximide and aromatic hydrocarbon fungicides in Ustilago maydis. Fungal Genetics and Biology 32, 183193. The cAMP signal transduction pathway mediates the switch between yeast-like and filamentous growth and influences both sexual development and pathogenicity in the smut fungus Ustilago maydis. Signaling via cAMP may also play a role in fungicide resistance in U. maydis. In particular, the adr1 gene, which encodes the catalytic subunit of the U. maydis cAMP-dependent protein kinase PKA ; , is implicated in resistance to the dicarboximide and aromatic hydrocarbon fungicides. In this study, we examined the sensitivity of PKA to vinclozolin and could not demonstrate direct inhibition of protein kinase activity. However, we did find that mutants with disruptions in the ubc1 gene, which encodes the regulatory subunit of PKA, were resistant to both vinclozolin and chloroneb. We also found that these fungicides altered the morphology of both wildtype and ubc1 mutant cells. In addition, strains that are defective in ubc1 display osmotic sensitivity, a propPresent address: Department of Biology, Emory University, 1510 Clifton Road, Atlanta, GA 30322. 2 Present address: Discovery Technologies Ltd., Allschwil, Switzerland. 3 Present address: BASF Agro Research, Princeton, NJ 08543-0400. 4 To whom correspondence should be addressed. Fax: 604 ; 822-6097. E-mail: kronstad interchange.ubc.
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