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Kate's story Kate is a 41-year-old working mother. She recently visited her family doctor and had this to say: "I have a lot of trouble relaxing when I get in bed at night. I feel like there's an electric current running through my legs, and I can't fall asleep. I have to move my legs around in bed or get up and walk around. This helps a little, but sometimes the urge to move comes back. I fall asleep eventually, but I still feel tired the next day." Kate's doctor asks her more questions about her symptoms. He finds out that the same thing happened when she was pregnant, but it cleared up after she had her daughter. Kate has talked to her father about it, and he has the same problem with jittery legs at night. Kate's father told her that it's just a sleep problem that they both have to live with. Kate's father is right about one thing--he and his daughter probably have a sleep problem called restless legs syndrome, or RLS. He's wrong about something else, though. Kate and her father do not "have to live with" these symptoms. Their family doctor can help. What is RLS? RLS is a disorder of sensation and movement that affects both men and women. It can occur at any age, including during childhood, but often worsens with age and becomes a problem for older adults. RLS affects the quality of sleep, which in turn can interfere with daytime activities. Some cases of RLS are related to other conditions, such as pregnancy, iron-deficiency anemia or kidney failure. Other cases of RLS have no known cause. RLS may be hereditary run in your family ; . What does it feel like to have RLS? People who have RLS sometimes say it's difficult to describe their symptoms. If you have RLS, you may have a "creepy-crawly" feeling in your legs that makes you want to move around. Because this feeling tends to start when you're lying still, you may have trouble sleeping at night. Or, you may find that you have the sensation any time you sit still, such as when you're working at a desk, watching a movie or reading. Moving your legs makes the feeling go away for a few minutes, but it comes back after you sit or lie still again. How does my doctor know I have RLS? Tell your doctor about the restless sensations. He or she will ask you questions about your symptoms, such as when they start and whether you're able to do anything to make them go away. He or she may also ask you if other people in your family have the same problems. Tell your doctor about any medicines--including over-the-counter OTC ; medicines--that you're taking. Certain medicines can make RLS symptoms worse. Your doctor can recommend or prescribe another medicine if this seems to be happening to you. What can I do to feel better? See the box below for a list of things that you can do at home to help relieve your symptoms. Your doctor may decide that medicine can help. Although RLS is not Parkinson's disease, medicines used to treat Parkinson's may be taken in lower doses by people who have RLS. If your iron levels are low, you may be helped by an iron supplement. Sleep aids called benzodiazepines and pain medications called opioids may also relieve symptoms. In some cases, an anticonvulsant medicine usually used to stop seizures ; can be helpful. You may worry about becoming addicted to these medicines, but because they are taken in low doses, the risk of addiction is fairly low. Your doctor can work with you to keep your risk of addiction low.
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The median number of days from baseline to achieve a sustained response was also the same in the two treatment groups 43 days ; and the difference was not statistically significant p .05; Table 6 ; . The time to sustained response was defined as the number of days from baseline to the first visit at which a sustained response was initiated.
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