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Compounds are similar, the relatively long intracellular T112 of 2', ddATP ; allows ddl to be administered twice a day instead of the four to six times per day necessary for AZT and ddC. Dosing of d4T has been reduced from three to two times per day in phase I trials 25 ; . Differences in the dosing schedules would result in transpiacental gradients at least twice as frequently for AZT and ddC compared with ddl or d4T. The most complete developmental and antepartum kinetic information for the dideoxynucleosides has been gencrated for AZT. Table 2 summarizes the pharmacokinetics of AZT in a variety of species in pregnant and nonpregnant females as well as various neonatal ages. The only pararneters found to differ between the pregnant and nonpregnant state are area under the concentration time curve AUC ; and clearance in the study by Watts et al. 26 ; . However, the antepartum clearance in the study by O'Sullivan et al. 27 ; resembles the postpartum clearance in the Watts et al. 26 ; study indicating that a true difference may not exist. No differences in kinetic parameters are seen in the monkey antepartum and postpartum after AZT administration 28 ; . The elimination T112 of ddI in two pregnant women during the second trimester was 0.76 and 1.18 h 29 ; . Although not shown, the pharmacokinetics of ddl in these two women were not different from published values for nonpregnant subjects. Information regarding the pharma and xalatan.
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Calcium Calcium is a mineral that the body needs for various functions in the body, including building and maintaining bones and teeth, blood clotting, the transmission of nerve impulses and the regulation of the rhythm of the heart. Calcium is necessary for bone health and to prevent osteoporosis. The amount of calcium needed by the body at various ages is shown in Table 3 below. The best way to obtain needed calcium is from food. Foods that are high in calcium include dairy products, such as milk, yogurt and cheese, calcium-fortified juices and zestoretic.
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Current guidance from the National Institute for Clinical Excellence NICE ; states that "the use of paclitaxel Pt combination therapy in the treatment of recurrent or resistant ; ovarian cancer i.e. second-line or salvage therapy ; is recommended if the patient has not previously received this drug combination".22 If, however, the patient has already received both drugs, the combination of paclitaxel and Pt-based therapy in recurrent or resistant ; ovarian cancer is not recommended. The choice of an alternative drug is then very much dependent on those previously used. No detailed recommendations or guidance have been issued about the choice of alternative second-line salvage therapies for the treatment of ovarian cancer. The Trent Development and Evaluation Committee has evaluated the use of topotecan after the failure of first-line or subsequent therapy in ovarian cancer and found that "topotecan is moderately effective in palliation of ovarian cancer refractory to other drugs".23 The committee's report stated that "its usefulness in combination with other effective cytotoxic agents and or in first-line treatment of ovarian cancer remains to be determined.
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