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Sung JH, et al. Protective effect of glutathione in HIV-1 lytic peptide 1induced cell death in human neuronal cells. J Neurovirol. 2001 Oct; 7 5 ; : 45465. Pouillart P, et al. Therapeutic effects of GSH Cysteine Anthocyan administered by mouth in the treatment of polymetastic colon cancer. Curie Institute, Dept. of Medical Oncology, Paris, France. 1999. Bonnerstag B, et al. Reduced glutathione and S-aceylglutathione as apoptosisinducing agents in cancer therapy. Cancer Letters. 1996; 110: 63-70. Kamei H, et al. Suppression of tumor cell growth by anthocyanins in vitro. Cancer Invest. 1995; 13 6 ; : 590-4, for example, obesity.
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PROFESSOR OF MEDICINE THE CARMEN L. BUCK PROFESSOR OF CANCER RESEARCH UNIVERSITY OF KENTUCKY MEDICAL CENTER I. Office Address: Thyroid Oncology Program, Div. of Hematology & Oncology, Rm. CC455 Department of Internal Medicine, Univ. of Kentucky Medical Center 800 Rose Street, Lexington, KY 40536-0093 Telephone: 859 ; 323-3778 FAX: 859 ; 257-7715 Email: kbain1 uky Spouse: M. Sara Rosenthal, Ph.D., Assist. Prof., UK.
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Investigation of children with suspected abuse: To prepare a clinical guideline on the identification of children who have been subject to physical, sexual or emotional abuse or who have a fabricated or induced illness. Chronic kidney disease: To prepare a clinical guideline for the NHS in England on the early identification, early management and timely referral of adult patients with chronic kidney disease in primary and secondary care. Spinal cord compression: To prepare a clinical guideline on the diagnosis and management of patients with metastatic spinal cord compression. Clinical management of borderline personality disorder: To develop a guideline for the evidence-based primary and secondary care treatment of adults diagnosed with borderline personality disorder and to consider which settings are most appropriate for which interventions. Where appropriate evidence related to those with learning disability should be included. Clinical management of antisocial dissocial ; personality disorder: To consider preventative and treatment interventions for antisocial personality disorder in education, in primary health care and in specialist services including prisons for adults and children and adolescents and to consider which treatment settings are most appropriate for which intervention. 5. The technology appraisal topics referred to NICE are: Autologous tumour vaccine for stage i-iii renal cell carcinoma: To appraise the clinical and cost effectiveness of ATL autologous tumour vaccine ; within its licensed indications for stage i-iii renal cell carcinoma. Idaraparinux sodium for the prevention of stroke in patients with atrial fibrillation: To appraise the clinical and cost effectiveness of idraparinux sodium for the prevention of stroke in patients with established non-reversible atrial fibrillation. Idaraparinux sodium for the prevention of recurrent venous thromboembolism: To appraise the clinical and cost-effectiveness of idraparinux sodium for the prevention of recurrent venous thromboembolism. Neuro-imaging in the first onset atypical psychosis: To appraise the clinical and cost effectiveness of structural neuroimaging MRI and CT ; to identify organic causes of first episode psychosis. Cochlear implants: To appraise the clinical and cost effectiveness of cochlear implants in severe to profound deafness in children and adults. Recombinant factor VIIa for traumatic bleeding: To appraise the clinical and costeffectiveness of the use of recombinant factor VIIa for the treatment of traumatic bleeding. Rimonabant for smoking cessation, weight loss and reduction of cardiovascular risk factors of overweight obesity: To appraise the clinical and cost effectiveness of rimonobant Acompia ; as part of cardiovascular risk modification by reduction of visceral obesity and accompanying benefits on other risk factors. Certolizumab pegol and natalizumab for the treatment of moderate to severe Crohn's disease: To appraise the clinical and cost effectiveness of the use of certolizumab pegol within its licensed indications for Crohn's disease: and to appraise the clinical and cost effectiveness of the use of natalizumab within its licensed indications for Crohn's disease. Varenicline for smoking cessation: To appraise the clinical and cost effectiveness of varenicline for smoking cessation. Alteplase for acute ischaemic stroke: To appraise the clinical and costeffectiveness of alteplase for the treatment of acute ischaemic stroke. Rituximab and abatacept for the treatment of refractory rheumatoid arthritis: To appraise the clinical and cost effectiveness of abatacept for the treatment of and advair.
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12 In early 2006, the GDF announced that it would converge with the GLC. Procurement functions of the GDF and GLC already have been combined. Plans to combine their application, review, monitoring, and evaluation functions are currently underway. For more information about the GDF GLC convergence, see section 2.3 of this report. 13 Stop TB Partnership. : stoptb gdf whatis what is . Accessed 2 28 07. As per "Global Drug Facility: An Introduction" Available in PDF format: . stoptb gdf documents FS%20GDF%20An%20Introduction June06 . Compendium and alendronate.
La segona pregunta, dividida en tres apartats, se centrava prpiament en el treball terminolgic, i demanava quin s el tipus de tasques que es duen a terme normalment tamb valorant-les segons la freqncia 1 major freqncia, 5 menor freqncia ; . El primer apartat es referia a la recerca sistemtica. Un dels serveis ens va respondre que, amb molt poca freqncia, acomplia la tasca d'elaborar glossaris plurilinges; un altre va marcar amb una creu sense indicar amb quina freqncia ; que elabora vocabularis plurilinges especificant que entenem per vocabularis repertoris terminolgics amb equivalncies i sense definicions, que tamb s'han denominat glossaris segons referncies terminolgiques ms recents i el tercer i quart serveis lingstics no ens aporten cap dada al respecte, per la qual cosa podem deduir que no realitzen cap tipus de recerca sistemtica en terminologia. L'aparentment molt baixa dedicaci dels serveis lingstics fins i tot del que t una rea de terminologia definida a les tasques de recerca sistemtica bsicament, elaboraci d'obres terminolgiques ; pot estar causada per la gran inversi en recursos humans, materials i de temps que es necessita per dur a terme treballs d'aquest estil. La segona part de la pregunta 2 demanava que, en el cas que es realitze alguna tasca de recerca sistemtica, s'indique quin s l'mbit majoritari juridicoadministratiu, tecnicocientfic, audiovisual o literari ; dels termes amb qu es treballa. Ja hem vist que, segons la pregunta anterior, noms dos dels quatre serveis lingstics enquestats realitzen tasques de recerca sistemtica; i segons han respost, l'un treballa predominantment amb termes juridicoadministratius, i l'altre amb termes tecnicocientfics. Aquestes dades coincideixen amb les respostes de la primera pregunta, que posaven de manifest que es treballa amb molta freqncia amb textos juridicoadministratius i en algun cas tamb amb tecnicocientfics. Cal destacar que aquests dos mbits s'inclouen dins els que Hurtado 2001, p. 59 ; considera marcats pel camp i qualifica com textos especialitzats. Aquesta idea, juntament amb la constataci de l'existncia d'un treball terminolgic sistemtic centrat especficament en els mbits juridicoadministratiu i tecnicocientfic, pot servir com a orientaci per millorar els programes formatius dels nostres llicenciats i llicenciades en Traducci i Interpretaci en forma d'intensificacions en aquestes rees. La tercera part de la pregunta 2 plantejava tot un seguit de tasques relacionades amb la recerca puntual en terminologia per tal de determinar quines eren les que realitzen habitualment les persones que treballen en els SLU. Les persones enquestades havien de contestar valorant la freqncia amb qu duien a terme aquestes tasques, per en un parell de casos, a causa de la gran freqncia general amb qu s'executen aquests treballs, les persones que van contestar van decidir marcar noms amb una X les tasques que realitzen sense qualificar-les. Per aquest motiu, hem optat per reflectir quantitativament quines sn les tasques de recerca puntual que realitzen els SLU sense fer cap altra valoraci. Hem pogut comprovar que la majoria tres de quatre ; dels serveis lingstics resolen consultes terminolgiques a travs del correu electrnic i que aquesta via s la 67.
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This drug decreases weight, reduces waist circumference and increases adiponectin, a protective substance. The benefit was sustained after two years of follow-up". "Current greatest challenge is to attempt a comprehensive approach of cardiometabolic risk. The central point is intraabdominal or visceral fat, which has demonstrated to be a true endocrine organ producing substances that increase risk. This fat easily measured by means of the waist circumference, a marker that makes risk tangible". "The fact that one every four persons have abdominal obesity causes concern. Those with abdominal obesity and other clinical forms of cardiometabolic risk factors insulin-resistance, dislipidemia, type 2 diabetes or metabolic syndrome ; will obtain the maximum benefit from this drug". About ACOMPLIA ACOMPLIA works by selectively blocking CB1 receptors found in the brain and in peripheral organs important in glucose and lipid or fat ; metabolism, including adipose tissue, the liver, gastrointestinal tract and muscle. CB1 receptor blockade with ACOMPLIA acts to decrease the overactivity of the endocannabinoid system EC system ; .The EC system is a recently characterised physiological system that includes receptors such as the CB1 receptor, and it is believed to play an important role in regulating body weight and in controlling energy balance, as well as glucose and lipid metabolism. About sanofi-aventis Sanofi-aventis is the world's third largest pharmaceutical company, ranking number one in Europe. Backed by a world-class R&D organisation, sanofi-aventis is developing leading positions in seven major therapeutic areas: cardiovascular, thrombosis, oncology, metabolic diseases, central nervous system, internal medicine and vaccines. Sanofi-aventis is listed in Paris EURONEXT: SAN ; and in New York NYSE: SNY and clavulanate.
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Rimonabant AcompliaTM ; is now available in the UK for the treatment of obese patients BMI 30 kg m2 ; , overweight patients BMI 27 kg m2 ; with associated risk factor s ; , as an adjunct to diet and exercise. NICE has already produced guidance on the other anti-obesity drugs orlistat and are due to publish a guideline on the treatment of obesity in November 2006. Summary of Product Characteristics for rimonabant link ; NICE guidance on orlistat link.
PRWEB ; September 12, 2007 -- Technologies for the management of obesity span surgical approaches, medical supervised severely restricted diets, drug therapies, OTC treatments, biopharmaceuticals, non-pharmacologic approaches and weight maintenance approaches. MedMarket Diligence maintains a focus on ongoing developments with it coverage of obesity and has completed a 2007 analysis on the worldwide market for products in the management of obesity. "The recent decision by Sanofi-Aventis to withdraw its FDA application for the anti-obesity drug rimonabant, marketed as Acomplia, highlights the need for an effective pharmaceutical treatment for obesity, " says Patrick Driscoll, President of MedMarket Diligence. "While developers in the market for device and other products to treat clinical obesity are working aggressively, it is clear that an effective pharmaceutical treatment will hold tremendous potential to compete with all treatment types." The obesity treatment market worldwide is set to grow enormously, and will reach 6.4 billion by 2015. This includes prescription drugs for weight loss and maintenance; devices used in bariatric surgery and follow-up; and the predicted sales of drugs and devices with anticipated launch dates through 2015 The MedMarket Diligence report on the "Worldwide Market for the Clinical Management of Obesity" describes the clinical trends in the management of the obese, the products on the market and the status of those in development for bariatric surgery, drug therapy, gastric stimulation devices, brain stimulation devices, combination therapies and genetic therapy. The report provides a current and forecast market for these products in the U.S., Europe and Rest of World, and profiles key companies in the market, detailing the current products, products in development, market position and overall businesses in obesity management. The report is described, with preliminary table of contents, at : mediligence rpt rpt-s825 . The report can be purchased direclty at s: mediligence store page22 . For additional information, contact Patrick Driscoll, at 949 ; 859-3401, or patrick mediligence com. About MedMarket Diligence MedMarket Diligence provides tactical decision-making solutions on medical technology to the medical products and investment industries. The company publishes the MedMarkets newsletter, a monthly analysis of the market implications of new medical technologies, dedicated Reports on technology markets and the Medtech Startups Database.
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INTRODUCTION : At present CEA is one of the popular surgical treatment in Europe and America Walter Grand but not still in Japan. Our clinical impression on CEA is that the character of CEA in Japanese is somewhat different from CEA in Caucasians. For example; 1 ; The location of Japanese carotid The major morbidity in aneurysm surgery is post-operative ischemic phenomena. The author bifurcation are higher than Caucasians. 2 ; Japanese plaques are tight and fibrous, therefore reviews 45 consecutive surgical cases of unruptured intracranial aneurysms in 40 patients. sometimes it is difficult to remove the plaque during CEA. Those differences might be based There is still controversy as to the indications and necessity of surgical treatment of unruptured on the racial difference. intracranial aneurysms. Many of the series in the literature relate to group studies on the METHODS : We have performed over 170 CEAs in past 15 years. All cases were operated safely surgical treatment of unruptured aneurysms or multiple center collaborative studies. The with T-tube shunt devised our original shunt tube ; and serial monitoring such as ICA blood flow current series is limited to one neurosurgeon and therefore may approximate the individual by an electromagnetic flow meter, stump pressure and SEP. To clarify the characteristics of results that an aneurysm surgeon may experience. Japanese CEA, we compared angiographical findings, clinical symptoms, risk factors and The size of the aneurysms varied from 3mm to over 25mm in diameter. The majority of the histopathological findings of plaques between in Japanese and in Hungarian patients. Using this aneurysms were in the 510mm range. As in other series, females predominated at about 31 new shunt system, total mortality and morbidity rate were 0% and 2.4% respectively. and the age range was from 10 68. Temporary morbidity included third nerve palsy, deep vein RESULTS : The location of Japanese carotid bifurcation and the lesion are higher about one thrombosis, aphasia, CSF leaks and in rare instances vasospasm. The predominant presenvertebrae level than Hungarian fs and the diameter of catotid are also narrow. Japanese tation was headache and incidental findings from investigation for other entities. Serious patients was mainly distributed around the C3 level. The lesions of stenosis distributed to C2 morbidity and post-operative infarction were encountered in two of the five giant aneurysms. level in many cases. Among clinical symptomes, amaurosis fugax and bruit are very few, There was one instance of blindness in one eye after a carotid ophthalmic aneurysm. moreover the number of hyperlipidemia as a risk factor are also few in Japan. The conclusion from this series is that the morbidity after surgery for unruptured intracranial CONCLUSION : The operative procedure will be difficult in Japanese patients and CEA for Asian aneurysms is relatively low for non-giant aneurysms and compares favorably with the natural patients might be taken longer operation time than Caucasian because the level of bifurcation history, morbidity and mortality in most of the series in the literature. At the same time the is high, carotid diameter is narrow and plaques are composed high grade of fibrous tissue in morbidity for surgery on unruptured giant aneurysms remains high and this is also confirmed Asian patients. That the reason why we have devised suitable shunt tube and use for Asian by the literature. With more and more MRI's and MRA's for many different entities, the problem patients. We have demonstrated CEA can be safely and easily performed with a routine of approaching unruptured intracranial aneurysms will continue to cause debate and concern. application of this shunt system and intraoperative Downloaded from stroke.ahajournals by on September 21, 2007 monitorings, for example, endocannabinoid.
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