Etretinate improves sclerotic skin of systemic sclerosis T Ikeda, 1 K Uede, 1 H Hasizume2 and F Furukawa1 1 Dermatology, Wakayama Medical University, Wakayama, Wakayama, Japan and 2 Dermatology, Hamamatu University School of Medicine, Hamamatu, Shizuoka, Japan There are few satisfactory effective treatments for skin sclerosis of systemic sclerosis SSc ; . Recently we reported SSc patients treated with vitamin A derivative etretinate, which is used for psoriasis with the effect to normalize the epidermic cell turn-over time. The aim of this study is to evaluate the advantage of etretinate for skin sclerosis of SSc by the modified Rodnan total skin thickness score. We enrolled 32 cases whose sclerotic changes from first visits had been followed up. Twelve cases were treated with etretinate, including 5 cases together with other treatments that have or had reported they improved skin sclerosis of SSc, that is, systemic steroids, immunosuppressants, D-penicillamine, and or bucillamine. Twenty cases were not treated with etretinate, including 13 cases together with other treatments. They were treated with 0.5mg kg day etretinate as the initial dose and it was tapered after skin sclerosis improved or when side effects appeared. It was considered as significant improvements that sustained score became less than 25% of the score when treatments had started. Sixty percent 3 5 ; of cases treated with both etretinate and other treatments and 85.7% 6 7 ; of cases treated with etretinate but not together with other treatments had definite significant improvements. Whereas, improvements did not occur in the cases who did not recieve both etretinate and other treatments. Only 7.7% 1 13 ; of cases treated with not etretinate but other treatments had improvements. In all the cases treated with etretinate, and in the cases with etretinate but not together with other treatments, the mean of the sustained score decreased significantly compared with that of the score when treatments was started P0.01 ; . It was suggested that etretinate was a useful treatments for sclerotic skin of SSc.
Table 2. The primary tuberculosis drug doses in adults, because use of tinidazole.
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TABLE 2. Characteristics of 10 patients treated with VRC.
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Lipids For Study AI424-043, changes from baseline in fasting LDL-cholesterol, HDL-cholesterol, total cholesterol, and fasting triglycerides are shown in Table 14. Table 14 Lipid Values, Mean Change from Baseline, Study AI424-043 REYATAZa Baseline Week 24 mg dL mg dL Changec n 143d ; n 123d ; n 123d ; LDL-Cholesterole, f HDL-Cholesterol Total Cholesterol Triglyceridesf.
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The health status of the callers was reported as excellent 46% ; , good 41% ; , fair 7% ; and poor 6% ; . Over one half of the health symptom reports 51% ; noted pre-existing conditions of allergy, asthma and or eczema. On average, callers reported three symptoms per report range 1-12 ; . Headache, shortness of breath, redness, itching, and burning of the eyes, stuffy or runny nose, sore throat, cough and upset stomach or nausea and a "metallic taste" were described. Self-care was the most frequent described planned action. Also, 37 reports planned to followup or had visited with a physician and four cases had visited or planned to visit a hospital emergency room. The symptoms self-reported to the provincial MOTH line and the CHR Health support line are the result of a passive survey in which the caller was sufficiently motivated to call and report symptoms. As the callers are not matched to a control group, it is not possible to make causeand-effect conclusions regarding the symptoms reported. The main goal of the health support line was to document what the community reported. The Committee relied upon the controlled study design of the General Population Survey and the review of the Physician Office Visits for an interpretation of possible health symptom increases related to the spray program. The objective of the General Population Survey was to determine if there were detectable short-term, self-reported physical and mental health effects in adults during the aerial spraying of Foray 48B. This analysis also examined relationships between people's attitude towards the spray program and other factors such as reported symptoms and demographics. A random sample of phone numbers and related addresses was drawn for households in the CHR. Postal codes were used to identify whether a household was inside or outside of the spray zone. Telephone interviews were conducted on people 19 years of age or older within this random sample. Five attempts at callbacks were attempted before a new number was selected. Respondents were asked questions about their mental and physical health using a standardized form. They were queried about specific symptoms and were asked to provide.
Krieger et al showed that spontaneous resolution can occur in men and this remains a possibility in the three contacts that responded , 15 whether all partners of patients with resistant trichomoniasis should receive high-dose tinidazole and a broad- spectrum antibiotic is not known and is an area for further investigation and urso.
Dr. Satyawati Mahendru, Jr. Consultant, Department of Nuclear Medicine, ACTC.
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The nitroimidazoles comprise the only class of drugs useful for the oral or parenteral therapy of trichomoniasis. Of these drugs, metronidazole and tinidazole are available in the United States and are cleared by the FDA for the treatment of trichomoniasis. In randomized clinical trials, the recommended metronidazole regimens have resulted in cure rates of approximately 90%95%, and the recommended tinidazole regimen has resulted in cure rates of approximately 86%100%. The appropriate treatment of sex partners might increase these reported rates. Randomized controlled trials comparing single 2 g doses of metronidazole and tinidazole suggest that tinidazole is equivalent to, or superior to, metronidazole in achieving parasitologic cure and resolution of symptoms 170 ; . Treatment of patients and sex partners results in relief of symptoms, microbiologic cure, and reduction of transmission. Metronidazole gel is considerably less efficacious for the treatment of trichomoniasis 50% ; than oral preparations of metronidazole. Topically applied antimicrobials e.g., metronidazole gel ; are unlikely to achieve therapeutic levels in the urethra or perivaginal glands; therefore, use of the gel is not recommended. Several other topically applied antimicrobials occasionally have been used for treatment of trichomoniasis; however, these preparations probably do not have greater efficacy than metronidazole gel. Follow-Up Follow-up is unnecessary for men and women who become asymptomatic after treatment or who are initially asymptomatic. Some strains of T. vaginalis can have diminished susceptibility to metronidazole; however, infections caused by the majority of these organisms respond to tinidazole or higher doses of metronidazole. Low-level metronidazole resistance has been identified in 2%5% of cases of vaginal trichomoniasis. High-level resistance is rare. Tiniidazole has a longer serum half-life and reaches higher levels in genitourinary tissues than metronidazole. In addition, many T. vaginalis isolates have lower minimum inhibitory concentrations MICs ; to tinidazole than metronidazole. If treatment failure occurs with metronidazole 2 g single dose and reinfection is excluded, the patient can be treated with metronidazole 500 mg orally twice daily for 7 days or tinidazole 2 g single dose. For patients failing either of these regimens, clinicians should consider treatment with tinidazole or metronidazole at 2 g orally for 5 days. If these therapies are not effective, further management should be discussed with a specialist. The consultation should ideally include determination of the susceptibility of T. vaginalis to metronidazole and tinidazole. Consultation and T. vaginalis susceptibility testing is available from CDC telephone: 770-488-4115; website: : cdc.gov std.
Tinidazole is not recommended during the first trimester of pregnancy and valproic.
Dientamoeba fragilis: doxycycline 2.5 mg kg to 100 mg orally 12 hourly for 3-7 d not 8 y ; , metronidazole 10 mg kg to 400 mg orally 8 hourly for 3-7 d Giardia intestinalis: tinidazole 50 mg kg to 2 g orally as single dose, metronidazole 30 mg kg to 2 g orally daily for 3 d Treatment Failure: metronidazole 10 mg kg to 400 mg orally 8 hourly for 7 d Blastocystis hominis: probably none required; metronidazole 10 mg kg to 400 mg orally 8 hourly for 7 d, metronidazole benzoate suspension 30 mg kg d to maximum 1.2 g d orally in 3 divided doses for 7 d, furazolidone 150 mg orally not for infants 1 mo; 1 mo - 1 y: 6.25-12.5 mg; 1-4 y: 25 mg; ? 5 y: 50 mg ; 6 hourly for several months Balantidium coli: tetracycline 500 mg orally 6 hourly for 10 d, metronidazole 800 mg child: 10-15 mg kg ; orally for 5 d, paromomycin 1 g child: 11 mg kg ; every 15 minutes for 4 doses Schistosoma: praziquantel, niridazole or sodium stibogluconate + dexamethasone Fasciolopsis buski: hexylresorcinol Nanophyetus salmincola: niclosamide 2 g orally on alternate days for 3 doses, bithionol 50 mg kg as a single dose on alternate days for 2 doses Other Flukes: praziquantel 25 mg kg orally 8 hourly for 1 d, tetrachloroethylene 0.1 mL kg to orally Taenia: praziquantel 10 mg kg orally as a single dose, niclosamide 2 g child 11-34 kg: 1 g; 34 kg: 1.5 g ; in single dose chewed thoroughly then purgative 3-4 h later, paromomycin 1 g child: 11 mg kg ; every 15 minutes for 4 doses Hymenolepis: praziquantel 25 mg kg orally as a single dose, niclosamide 2 g dose chewed thoroughly daily for 7 d child: 11-34 kg: 1 g as single dose then 500 mg daily for 6 days; 34 kg: 1.5 g as a single dose then 500 mg daily for 6 d ; , paromomycin 45 mg kg orally daily for 7 d Diphyllobothrium: niclosamide 2 g chewed thoroughly child 11-34 kg: 1 g; 34 kg: 1.5 g ; given once as a single dose, praziquantel 10-20 mg kg orally as a single dose, paromomycin 1 g child: 11 mg kg ; every 15 minutes for 4 doses Other Tapeworms: niclosamide, dichlorophen, mepacrine Trichuris trichuria: mebendazole 100 mg 10 kg: 50 mg ; twice daily orally for 3 d not in first trimester or 6 mo ; , albendazole 400 mg ? 10 kg: 200 mg ; orally daily for 3 d not in pregnancy, lactation or 6 mo precede with loperamide initial dose 4 mg, then 2 mg after each unformed stool to maximum daily dose 16 mg ; if diarrhoea Strongyloides stercoralis: ivermectin 200 ? g kg orally with fatty food not children 5 y ; on day 1 and repeat after 7-14 d days 1, 2, 15 and 16 in immunocompromised ; , albendazole 400 mg ? 10 kg: 200 mg ; orally with fatty food once daily for 3 d and repeat after 7-14 days not in pregnancy, lactation or 6 mo; repeat after 1 w in complicated or disseminated infections ; , thiabendazole 25 mg kg to 1.5 g orally 12 hourly for 3 d not in first trimester or 6 mo ; , mebendazole Hookworms, Ascaris: pyrantel embonate 20 mg kg to 750 mg orally as a single dose repeat after 1 w if heavy infection ; , mebendazole 100 mg ? 10 kg: 50 mg ; orally twice daily for 3 d not in first trimester or 6 mo ; , albendazole 400 mg ? 10 kg: 200 mg ; orally as single dose not in pregnancy, lactation or 6 mo ; Enterobius vermicularis: pyrantel embonate 10 mg kg to 750 mg orally single dose, mebendazole 100 mg child 10 kg: 50 mg ; orally single dose not in first trimester or 10 kg ; , albendazole 400 mg child 10 kg: 200 mg ; orally single dose not in pregnancy, lactation or 6 mo ; Anisakis, Phocanema, Pseudoterranova: thiabendazole 25 mg kg to maximum 3 g orally twice daily for 3 d; surgery usually required Trichinella spiralis: mebendazole Other Helminths: thiabendazole Prophylaxis: Communities with Heavy Intestinal Helminth Exposure: albendazole 10 kg: 200 mg; 10 kg: 400 mg ; orally single dose every 4-6 mo to children 6 mo-12 y.
DBS Group has implemented policies and procedures to identify, measure, analyse and control risk across the firm. A governance framework has been established to provide a disciplined, consistent and tiered approach in the approval of the various risk frameworks policies procedures throughout the DBS organisation. The framework comprises four levels: Level 1 policies are Board-level approved firmwide risk frameworks; Level 2 policies are minimum corporate-level and subject-specific risk principles and standards; Level 3 policies are business or location-specific in nature; and Level 4 procedures underlie and support the policy implementation. These policies and procedures rely on constant communication, judgment, knowledge of products and markets, and controls by business and support units and valacyclovir.
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V. SEUTIN, L. MASSOTTE, J. SCUVEE-MOREAU, AND A. DRESSE SATIN, L. S. AND ADAMS, P. R. Spontaneous miniature outward currents in cultured bullfrog neurons. Brain Res. 401: 331339, 1987. SEUTIN, V., SCUVEE-MOREAU, J., AND DRESSE, A. Evidence for a nonGABAergic action of quaternary salts of bicuculline on dopaminergic neurones. Neuropharmacology 36: 16531657, 1997. TEPPER, J. M., TRENT, F., AND NAKAMURA, S. Postnatal development of the electrical activity of rat nigrostriatal dopaminergic neurons. Dev. Brain Res. 54: 2133, 1990. YUNG, W. H., H AUSSER, M. A., AND JACK, J. J. B. Electrophysiology of dopaminergic and non-dopaminergic neurones of the guinea-pig substantia nigra pars compacta in vitro. J. Physiol. Lond. ; 436: 643 667 and bextra.
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There is a lack of correlation between dose and risk of toxicity. Host-dependent factors seem to be important in predisposition to these reactions, and they are thought to have both metabolic and immunological components, which may determine individual susceptibility. These reactions tend to be serious and account for many drug-induced deaths. From a chemical i.e. structural ; point of view, ADRs may comprise type C and type D reactions. Type C, or chemical, reactions are those reactions whose biological characteristics can be either rationalised or even predicted based on the chemical structure of the parent drug, or of reactive intermediates and metabolites thereof. Type D, or delayed, reactions may occur many years after treatment such as, for example, second tumours years after treatment with chemotherapeutic agents. Also included in this category of ADRs are teratogenic effects seen in children after drug intake by the mother during pregnancy. Serious but rare ADRs including idiosyncratic reactions ; are usually only detected once a given drug has been used widely in large patient population and is in the post-marketing phase of the drug's lifecycle. Serious ADRs do occur despite extensive preclinical evaluation of a given new chemical entity i.e. drug candidate ; in laboratory animals and large numbers of patients enrolled in clinical trials in order to evaluate the efficacy and the safety of this drug candidate in humans. Several reasons for this phenomenon may exist, including the fact that large clinical trials, exposing perhaps up to 10, 000 patients to the new drug prior to registration, may not suffice to reliably detect rare ADRs.
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Fixed dose combination [FDC] are highly popular in the Indian pharmaceutical market and are particularly flourishing in the last few years. The rationality of FDCs should be based on certain aspects like: The drugs in the combination should act by different mechanisms. The FDC should have enhanced action compared to the additive effect of the individual ingredients synergy ; . The pharmacokinetics must not be widely different. Also important is that the combination should not have supra-additive toxicity of the ingredients. The World Health Organization's [WHO] Model List of Essential Drugs provides examples of some rational FDCs such as: Sulfamethoxazole + Trimethoprim. Antitubercular FDCs like Rifampicin + Isoniazid, Isoniazid + Ethambutol, etc. Antiparkinsonism FDCs like Levodopa + Carbidopa. Unfortunately, FDCs being introduced in India are usually irrational. The most pressing concern with irrational FDCs is that they expose patients to unnecessary risk of adverse drug reactions. For instance, pediatric formulations of Nimesulide + Paracetamol can induce severe hypothermia in small children and lead to shock. FDCs of Diclofenac + Serrapeptase do not offer any particular advantage over the individual drugs despite vigorous claims that Serrapeptase promotes more rapid resolution of inflammation. On the other hand, the patient is exposed to greater risk of gastrointestinal [GI] irritation and serious bleeding from unsuspected peptic ulceration. FDCs of quinolones and nitroimidazoles e.g. Norfloxacin + Metronidazole, Ciprofloxacin + Tinidazole, Ofloxacin + Ornidazole ; have not been recommended in any standard books, but continue to be heavily prescribed drugs in GI infections, pelvic inflammatory disease, dental infections, etc., to cover up for diagnostic imprecision and the lack of access to laboratory facilities. Such injudicious use of antibiotic FDCs can rapidly give rise to resistant strains of organisms, which is a matter of serious concern to the health care situation in our resource-poor country. A glaring example is the emergence of Ciprofloxacinresistant Salmonella typhi strains which have made treatment of typhoid fever a difficult and expensive proposition in India today. Over the years the Indian drug control authority has issued banned notifications on many FDCs like Analgin + Pitofenone, Vitamins B1 + B6 B12, Cyproheptadine + Lysine, etc. But are these measures sufficient? Obviously not, since these notifications have not deterred manufacturers from coming out with new irrational FDCs. At this crucial juncture, when the global community represented by WHO is making an all out effort to propagate the concept of essential drugs amongst consumers throughout the world, our official stance could be viewed as too meager. India being the world's second most populous country we should expect much more of ourselves and not pay mere lip service to the global campaign. Irrational FDCs also impose unnecessary financial burden on consumers. Medical practitioners who patronize such combinations could be the center of controversy when subjected to litigation in consumer forums, as these combinations do not find mention in standard text or reference books and reputed medical journals. Pharmaceutical manufacturers, however, continue to reap the benefits of huge sales, and therefore continue promoting them with vigor. Time has come for all of us, as practitioners and consumers, to raise this matter vociferously through all possible avenues. The campaign against meaningless FDCs must be carried on to every nook and corner of the country. The power vested in state-level drug regulatory authorities is often taken advantage of by pharmaceutical companies who push through irrational combinations without proper scrutiny. Therefore, in making this campaign a success we earnestly hope that our drug regulatory bodies would take urgent and stringent measures in mitigating such free flow of irrational FDCs. Amitava Sen.
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A set of 16 aligned influenza neuraminidase inhibitors117 in Table 4.10 exhibited a very poor correlation to activity log 1 C ; , with an average q2 value of -0.06593 for the combined set of local property descriptors. The values of q2 for all of the individual local property PLS analyses were observed to vary greatly among the rotated grids. The electronic density models, which gave the overall best scores, yielded a maximum q2 value of 0.682 and a minimum value of -0.012, with a range of 0.694 q2 units. The other local properties varied similarly, as shown in Figure 4.17. Local ionization potential IEL ; and local electronegativity ENEG ; periodically exhibit some measure of correlation to.
The density of healthy human liver is approximately 1.05 g mL ICRP, 2002 ; , and the specific gravity of water is 1.0 mg L. It was assumed that the density of healthy beef liver is approximately equal to the density of healthy human liver. The specific gravity of the artificial foodstuff, determined by the volume of water displaced using a piece of artificial foodstuff of known weight, was approximately 0.98 mg L n 1 ; . Therefore, for the purposes of this research project, the specific density of the artificial foodstuff was approximated to be 1.0 g L.
Scene of injury Endpoint: Dual superiority and non-inferiority test of day 30 mortality in the modified intent to treat MITT ; population; multiple organ failure and avoidance of allogeneic blood Status: Preliminary Phase III data Milestone: Final Phase III data early 2007 submit BLA mid-2007 ; Preliminary data from an open-label, U.S. Phase III trial in 722 patients showed that PolyHeme missed the primary endpoint of dual superiority and non-inferiority to standard treatment of salt water plus blood. In the MITT population 712 patients ; , the mortality rate was 13.2% vs. 9.6% for control with an upper limit confidence interval CI ; of 7.3%. The trial required an upper limit CI of 0% for superiority and 7% for non-inferiority. In the per protocol PP ; population 586 patients ; , PolyHeme met the non-inferiority endpoint with a mortality rate of 10.8% vs. 9.1% for control, and the upper limit CI was 5.8%. The safety endpoints of mortality at day 1 and 30 were not significantly different between the 2 groups. The day 1 mortality rate was 9.5% for PolyHeme vs. 7.4% for control in the MITT population, and 6.8% for both groups in the PP population. A re-analysis of the data will be required after 2 discrepancies in the dates of death were identified in the initial data. NFLD expects to have these final data in 4-6 weeks, which the company said might have an impact on its expected mid-2007 BLA submission to FDA. OxiGene Inc. OXGN; SSE: OXGN ; , Waltham, Mass. Product: Combretastatin A4P CA4P ; Business: Cancer Molecular target: Tubulin Description: A4 prodrug phosphatase-activated tumor vascular targeting agent Indication: Treat solid tumors Endpoint: Safety, recommend dose for Phase II III and anti-cancer activity; changes in tumor blood flow Status: Preliminary Phase II data Milestone: NA Preliminary data from an open-label, U.S. Phase II trial in 13 patients showed that 45 or 63 mg m2 of IV CA4P plus paclitaxel and carboplatin shut down blood flow in a advanced malignancies. Panacos Pharmaceuticals Inc. PANC ; , Watertown, Mass. Product: Bevirimat PA-457 ; Business: Infectious Molecular target: HIV capsid protein Description: Compound that binds to an immature form of the capsid protein and blocks the production of infectious particles Indication: Treat HIV infection Endpoint: Viral load reduction after 14 days; safety over 12 weeks Status: Preliminary Phase IIb data Milestone: NA Preliminary data from the first dose group 400 mg ; in a dose ranging Phase IIb trial of bevirimat did not show the viral load reduction necessary to continue the trial. Based on an analysis of plasma concentrations, the company believes the tablet formulation used in the study did not deliver the drug as expected. The company noted that a previous bioavailability study suggested the 400 mg tablet would be comparable to 200 mg of oral liquid bevirimat, which was the highest dose of that formulation used in a Phase IIa study. Instead, PANC said, the 400 mg tablet was equivalent to 100 mg of oral solution. PANC said it submitted a proposal to FDA to continue the trial while the company continues to develop an optimized formulation for commercialization. PANC.
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AMENDMENT NO. 8 On page 2, line 6, change " 2 ; " AMENDMENT NO. 9 On page 2, line 9, delete "individual" and insert "athlete" AMENDMENT NO. 10 On page 2, line 16, change " 3 ; " AMENDMENT NO. 11 On page 2, line 22, change " 4 ; " AMENDMENT NO. 12 On page 2, line 24, change " 5 ; " AMENDMENT NO. 13 On page 2, line 28, change " 6 ; " and delete "immediate" AMENDMENT NO. 14 On page 2, line 29, change "athlete" to "athlete" and delete "individual" AMENDMENT NO. 15 On page 3, delete line 5 and insert the following: " 7 ; 8 ; "Medical physician" means a person licensed to practice medicine by the board in the state. AMENDMENT NO. 16 On page 3, line 6, change " 8 ; " and change "athletes" to "athletes" and delete "individuals" AMENDMENT NO. 17 On page 3, delete line 12 and insert the following: " a ; Reconditioning procedures. b ; Operation of therapeutic devices and equipment. c ; Fitting of braces, guards, and other protective devices. d ; Referrals to other physicians, auxiliary health services, and institutions. 9 ; "Practice of prevention" shall include but is not limited to the following: a ; Working cooperatively with supervisors and coaches in establishing and implementing a program of physical conditioning for athletes. b ; Applying protective or injury-preventive devices such as taping, padding, bandaging, strapping, wrapping, or bracing. c ; Working cooperatively with supervisors, coaches, and a team physician or consulting physician in the selection and fitting of protective athletic equipment for each athlete and constantly monitoring that equipment for safety. d ; Counseling and advising supervisors, coaches, and athletes on physical conditioning and training such as diet, flexibility, rest, and reconditioning." AMENDMENT NO. 18 On page 3, line 13, change " 9 ; " AMENDMENT NO. 19 On page 3, delete line 16 and insert the following: " b ; Applying protective or injury-preventive devices such as taping, padding, bandaging, strapping, wrapping, or bracing." AMENDMENT NO. 20 On page 3, line 20, change "athletes" to "athletes" and delete "individuals" AMENDMENT NO. 21 On page 4, deletes lines 13 through 19 and insert the following: "C. The board, under its authority established in R.S. 37: 1281, shall fix fees for the purpose of administering the provisions of this Chapter in a manner established by its rules." AMENDMENT NO. 22 On page 4, line 27, delete "certificate or license" and insert "license or certificate.
Ask your doctor and or pharmacist for more information on the medications prescribed for you and your unique health care needs.
Projected Comments Launch New FDA-Approved Indications Anti-infective Treatment of 05 21 Available Tindamax was approved in Tindamax tinidazple ; agent bacterial vaginosis May 2004 for the treatment tablets Mission BV ; of trichomoniasis, Pharmacal giardiasis, and amebiasis. New First-Time Generic Drug Approvals None to report * Note: If FDA approved, agents are under P&T review and reside on the 3rd tier. Pipeline Analysis Drug Manufacturer FluMist Influenza Virus Vaccine Live, Intranasal ; spray MedImmune Therapeutic Class Flu vaccine Indication s ; Active immunization of healthy children and adolescents 5 to 17 years of age and healthy adults 18 to 49 years of age against influenza disease caused by influenza types A and B contained in the vaccine Treatment of patients with phenylketonuria PKU ; Status A complete response letter received to the supplemental biologics license application sBLA ; NDA filed Comments.
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Lowenstein DH, Alldredge BK. N Engl J Med. 1998; 338: 970-976. Greenblatt DJ, et al. J Pharmacol Exp Ther. 1989; 250: 134-140.
Oral dose 500 mg ; b Tinidazple Metronidazole 10.1 0.6 1.6 * 1.9 0.2 122.2 * 8.9 0.6 * 3.4 0.9 169.2.
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