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S ernst & young llp palo alto, california august 3, 2005 quicklinks exhibit 2 1 consent of independent registered public accounting firm quicklinks - click here to rapidly navigate through this document exhibit 2 consent of independent registered public accounting firm we consent to the reference to our firm under the caption experts in amendment no 1 to the registration statement form s-3 no 333-123958 ; and related prospectus of protein design labs, inc for the registration of its 00% convertible senior notes due february 15, 2012 and 10, 554, 750 shares of its common stock and to the incorporation by reference therein of our report dated march 12, 2004 with respect to the consolidated financial statements of esp pharma holdings and subsidiary, included its current report form 8-k ; dated february 7, 2005 filed with the securities and exchange commission and our report dated february 25, 2005 with respect to the consolidated financial statements of esp pharma holdings and subsidiary, included in its amendment to current report form 8-k a ; dated june 2, 2005 filed with the securities and exchange commission, for example, vincent urso.
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190. BALASPIRI L., TOTH G., TOTH M., SIROKMN F., KOVACS K., LASZLO F.A.: Synthesis and biological activities of some known arginine-vasopresein AVP analoguse as precursors of tritiated derivatives. Acta Chim. Hung. 115. 223-229. 1984. LASZLO F.A.: Commemoration ot the tenth anniversary ot the death of professor Mikls Julesz. Acta Med. Hung. 41, 3-6, 1984. LASZLO F.A., CSATI S., BALASPIRI L., MANNING M.: Effect ot the vasopressin antagonist d CH2 5Tyr Et VAVP on diuresis in rat. Acta Med. Hung. 41. 65-73, 1984. JANAKY T., LASZLO F.A., MORGAT J-L.: Tritiation of vasopressin analogues and their metabolic fate afterintravenous injection in the rat. Acta Med. Hung. 41, 43-54, 1984. KARCSU S., LASZLO F., TOTH L., JANCSO G., BACSY E.: Mitokondrilis Ca2 + -akkumulci, mint a neuronalis hyperaktivits morfolgiai jele Brattleboro patkny neurohypophysisben. K. O. T. 36, 174-178, 1984. McCOMB D.J., HUDSON J., KOVACS K., DOMOKOS I., LASZLO F.A.: Effects ot Tamoxifen and estrone on estrone induced transplanted rat pituitary adenoma. Fed. Proc. 43, 912, 1984. LASZLO F.A., CSATI S., BALASPIRI L.: Effect of the vasopressin antagonist d CH2 5Tyr Et VAVP on the antidiuretic action of exogenous and endogenous vasopressin. Acta Endocr. 106, 52-55, 1984. LASZLO F.A., CSATI S., BALASPIRI L.: Prevention of hyponatraemia and cerebral oedema by the vasopressin antagonist d CH2 5Tyr Et VAVP in rats treated with pitressin tannate. Acta Endocr. 106, 56--60, 1984. DCZI T., LASZLO F. A., SZERDAHELYI P., JOO F.: Involvement of vasopressin in brain oedema formation: further evidence obtained from the Brattleboro diabetes insipidus rat with experimental subarachnoid hemorrhage. Neurosurgery 14, 436--441, 1984. KARCSU S., TOTH L., MESZAROS T., LASZLO F.: 24.
Tetrahidropirans, espirocetals, etc. ; sn precursors d'antibitics. El procs de formaci d'un cicle es pot produir per dos camins, endo i exo. La ciclaci de tipus endo t lloc quan l'enlla que es trenca s endocclic a l'anell ms petit en formaci; de la mateixa manera, la ciclaci de tipus exo t lloc si l'enlla que es trenca s exocclic Esquema 30 ; . Baldwin62 va sistematitzar els resultats de les ciclacions descrites en la bibliografia, i va deduir una srie de regles, que es basen en els requeriments geomtrics de l'estat de transici.
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However, owing to the renal toxicity of the drug, indinavir use should be monitored carefully.
Substantially raises the risk of morbidity from a variety of conditions, including hypertension, dyslipidemia, and diabetes. The relative risk of developing diabetes increases by 9% for every kilogram of body weight above the recommended range. In the last decade, the percentage of obese overweight people living in the U.S. has risen to 54.9% of adults 20 years or older. It is now known that intra-abdominal adiposity is a strong predictor of myocardial infarction. Abdominal fat content is positively correlated with waist circumference. Nearly half of adult Americans have a waist circumference that exceeds the at-risk level, which is defined as 40 inches for men and 35 inches for women. Abdominal obesity is also associated with dyslipidemia and insulin resistance that may lead to type 2 diabetes and cardiovascular disease. Diabetes During the 1990s, the worldwide incidence of diabetes increased by one third. The number of people in the world diagnosed with diabetes may rise from the current 194 million to 333 million by the year 2025 if nothing can be done to slow this epidemic. Conclusive evidence indicates that good control of blood glucose can substantially reduce the risk of complications and slow disease progression in all types of diabetes. Both management of high blood pressure and lipid control are equally important. Weight loss lowers blood glucose levels in overweight and obese people with or without diabetes. It decreases the chance of developing diabetes, and in some patients diagnosed with diabetes, it can reduce HbA1c and blood glucose levels.2 Metabolic Syndrome Metabolic syndrome is a constellation of risk factors that collectively increase the risk of cardiovascular disease. Some risk factors for metabolic syndrome include abdominal obesity, elevated fasting blood glucose, lipid disorders, and elevated blood pressure. Metabolic syndrome is a precursor to diabetes, and it is becoming increasingly common as a result of an increased prevalence of obesity. More than 22% of Americans meet the criteria for this syndrome. The goal of treatment is to reduce the likelihood of the development of diabetes and to decrease cardiac risk factors. Diet and exercise target the underlying causes of metabolic syndrome and are the cornerstone of any treatment plan. Statins and gemfibrozil are used successfully to normalize lipid profiles, thereby lowering the risk of cardiovascular events. Optimal goals for hypertensive therapy are needed, and emerging evidence suggests that angiotensin-converting enzyme inhibitors may have a role in reducing the incidence of new-onset diabetes. The RIO Program Over 6, 600 patients have participated in the four studies in the Rimonabant in Obesity RIO ; Program. These studies have shown rimonabant's efficacy in treating obesity, diabetes, and metabolic disorders. RIO-Lipids: This study enrolled 1, 036 overweight or obese patients with untreatn ed dyslipidemia. During the trial, subjects were put on a reduced calorie diet for one year and were randomized to take 5 or 20 mg of rimonabant daily or placebo. The complete set of results for this trial has not yet been and valproic.
16 ; Notes 1 ; The names of the hydrocarbons given in Table 1 imply the configuration at the chiral centres in the side chain as given in the second column. The conventions of the sequence rule, however, mean that R may change to S without a change at the relevant atom when there is a change in the substitution or unsaturation, e.g. compare 6 and 7. A 2 ; Some tetracyclic triterpenoids may be regarded as trimethyl steroids, the three additional methyl groups being numbered 28 attached to C-4 with a-configuration ; , 29 attached to C-4 with P-configuration ; and 30 attached to 2-14 this numbering corresponds to that used for the triterpenoids. This type of nomenclature is especially useful for the parent hydrocarbons of biogenetic precursors of steroids. For .example, lanostane 17 is 4, 14-trimethyl-5a-cholestane, former name implying the 5a, 8P, 9a, lOP, the 13B, 14a, 17P, The change of configuration at C-9in cycloartane 18 is implied in the name, although it must be specified if called.
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Type compounds is likely associated with a precursor, the furfural, which is a component of diesel emission and plant vapour.38 These furan derivatives may also originate from the oxidation of isoprene.38 Some keto-carboxylic acids were also detected e.g. 4-oxo-pimelic acid ; which may be produced photochemically from hydrocarbon precursors. Among the SOA products detected in samples from Pertouli, at levels close to 1 ng m-3, was the C9 dioxocarboxylic acids, which may result from the ozonolysis of limonene Figure 13 ; .33, 39 Adipic acid hexanedioic acid ; has been reported as a product of the ozonolysis of -pinene in smog chambers.40, 41 This compound was also identified in the Giesta and Pertouli samples at levels ranging from 0.01 to 10.93 ng m -3 . Glutaric acid pentanedoic acid ; was present in our samples at concentrations ranging from trace levels to maximum values of 8.84 ng m-3. This last alkanedioic acid was identified in a smog chamber investigation as a product of the ozonolysis of pinenes. 40 In other laboratory experiment, Wngberg et al.42 observed the formation of pinane epoxide from the -pinene NO3 reaction Figure 14 ; . This secondary compound was also present in some Greek samples not exceeding 0.73 ng m-3. Pinic acid constitutes another secondary compound detected in the particulate matter. Laboratory experiments have revealed that its formation may be explained by two different mechanisms: i ; -pinene ozonolysis Figure 15 ; , 13, 40, 41, ii ; oxidation of -pinene by O3 NOx Figure 16 ; .47, 52-54 Pinonaldehyde and pinonic acid were detected in many samples from Portugal and Greece. In laboratory experiments with -pinene and OH radicals, ozone, or NO x the formation of these products was observed. 13, 33, 38, Mechanisms leading to the formation of these products are shown in Figures 15 and 17. The aldehyde may also take place in the particulate phase by oxidation of -pinene through reaction with other oxidising species such as NO3 and N2O5.30 Recently, Lee et al.61 have detected pinonaldehyde and pinonic acid, in smog chamber experiments, as particulate products from the photo-oxidation of -pinene in the presence of NOx and diesel soot.
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Once hydrolyzed, it competes with hmg-coa for hmg-coa reductase, a hepatic microsomal enzyme, thus reducing the quantity of mevalonic acid, a precursor of cholesterol.
Earnings before income taxes for the other healthcare segment increased to $86 million in 2002 from $42 million in 2001 primarily as a result of the addition of the medical imaging business from the dupont acquisition and strong growth in the convatec business and bextra.
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I: How come there are only a few medicines ; that you take? S: 'Cause I really like to limit it, I like to keep it to a minimum what I putting in my body. I: Why is that? S: It makes me nervous. I don't like mixing, I don't like trying to make myself, I, I know I don't think I can become dependant on anything, especially like, cause I don't take it that often, but I don't think it's really necessary to put stuff in my body when it is not necessary." [73] and cialis.
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What controls are in place at the Spokane Waste-to-Energy facility to keep contaminants from entering the environment? The goal of the Waste-to-Energy facility in Spokane is to properly dispose of solid wastes by high temperature combustion. High temperature combustion destroys hazardous products within the solid wastes and as a byproduct generates electricity and an inert ash. The following is a description of how controls at the permitted municipal Waste-to-Energy facility in Spokane keep contaminants from entering the environment, provided by Damon Taam at the Spokane Regional Solid Waste System: Solid wastes brought to the Waste-to-Energy facility are combusted in the boilers at 2500 degrees F and are kept at this temperature for about 45 minutes. The combustion chamber has very sophisticated combustion control systems that distribute the solid waste evenly to ensure that combustion is complete. The volume of solid waste combusted is reduced by 90 percent, leaving only ferrous metal scrap, glass and ash. The majority of problematic constituents in expired or unusable pharmaceuticals are organic in nature, which are destroyed almost completely through combustion. The combustion in this facility also destroys other hazardous products in the solid wastes, such as PCBs, dioxins and furans. The Thermal deNOx system injects anhydrous ammonia into the boiler where nitrous oxide NO ; and dioxides NO2 ; , thought to be precursors to acid rain and components of smog, are broken down into the elements nitrogen and oxygen.
Example 13 Drugs commonly considered to fall under the category of hormonal antineoplastics include leuprolide acetate and goserelin acetate. If a patient receives one of these subcutaneous, then receives a different chemotherapy agent IV push, how is this billed? CAH CPT coding 96409 1 unit Service Medicare OPPS coding Chemotherapy administration, C8953 1 unit intravenous, push technique, single or initial substance drug Chemotherapy administration, subcutaneous or intramuscular; hormonal anti-neoplastic 96402 1 unit and danazol.
If stearic acid were a precursor of oleic, stearic wx ould accumiulate at pH-I 7.3 to 7.6 where oleic synthesis is slow, at miiaximiiumii oleic acid svnthesis, stearic aci d accunmutlation would exhibit a miiinimumii value. These relationiships do inot hold with these data and ulsl ; uort earlier work in wN-hich it is suggested that stearic is niot a precuirsor of oleic 29.
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P4902 Symptoms of asthma and allergy in children in Sri Lanka: prevalence and association with sleep disturbance Stijn L. Verhulst 1 , Karolien Vekemans 1 , Erwin Ho 1 , Liselotte Aerts 1 , Sarah Jacobs 1 , Hiroshi Dhanapala 2 , Wilfried A. De Backer 3 , Kristine N. Desager 1 . 1 Pediatrics, University of Antwerp, Wilrijk, Belgium; 2 Pediatrics, University of Peradeniya, Peradeniya, Sri Lanka; 3 Respiratory Medicine, University of Antwerp, Wilrijk, Belgium The objective of this study was to determine the prevalence of asthma in 6 to year old children in an urban region of Sri Lanka and to investigate the association between asthma and allergy related symptoms and disturbed sleep and daytime symptoms. The ISAAC questionnaire and a validated sleep questionnaire were distributed among children of 2 schools in the city of Kandy, Sri Lanka. Of 800 questionnaires, 653 81.6% ; were returned. Mean age was 8.9 1.7 y; 45.5% were boys. Wheezing at any given time was reported by 89 children 13.7% 59 89% ; of these children reported wheezing in the last 12 months. The frequencies of symptoms which were significantly different between wheezing and non-wheezing children are presented in table 1. After adjusting for possible confounders, a positive association was found between wheezing and: daytime tiredness odds ratio [OR] 3.6 ; , restless sleep OR 2.5 ; and nocturnal awakenings OR 1.8 ; . Chronic rhinitis was related to restless sleep OR 2.0 ; . A strong association was found between hayfever and daytime tiredness OR 4.5 ; . Snoring was associated with daytime tiredness OR 2.5 ; , restless sleep OR 3.4 ; , apneas OR 1.6 ; and nocturnal awakenings OR 1.7.
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The complex microflora colonizing the human gut changes with age and may play a role in the observed increase in both infectious and chronic disease in the elderly. Within Europe, there appears to be regional differences in incidence of disease as well as differences in life span and degree of independence in later years. The gut microflora is amenable to modulation using probiotics, prebiotics and synbiotics, and the elderly represent a population group for which such strategies may be particularly suitable. CROWNALIFE has confirmed that the gut microflora within elderly people differs from younger adults, showing a much greater degree of species diversity. Through generation of 16S rRNA based phylogenetic inventories of the faecal microflora of healthy elderly individuals 65 years ; the elderly 80% of cloned 16S rDNA sequences corresponded to previously uncultured bacteria while 1 3 of these represented novel phylogenetic lineages. In a pilot study examining microflora composition within different age groups in two different countries, the increased microflora diversity has been confirmed quantitatively using a set of 16 phylogenetic probes. To affect beneficial modulation within the gut microflora CROWNALIFE has employed a synbiotic formulation, and is determining the suitability and efficacy of this approach by monitoring changes within relative bacterial numbers and microbial biomarkers important in gastrointestinal health and disease. Using a holistic approach, microflora modulation has been analysed with respect to regional dietary differences within Europe. In parallel, novel synbiotic products, employing probiotic strains selected for anti-pathogenic activity from the elderly gut and efficacious prebiotics both existing and novel ; have been formulated to constitute second generation functional foods specifically designed to affect beneficial modulation of the elderly gut microflora towards improved gut health.
Scheme 4. Synthesis of several compounds 7, by reduction of their carbonyl precursors. The products are denoted as before, as if they were obtained from the hypothetical corresponding ketones. Reagents and conditions: i ; AlCl3, ClCH2CH2Cl, reux, 34% yield for 7nz; ii ; NaBH4, MeOH, rt, 12 h, 89, 85, and 87% yield for 7oy, 7oz, and 7py, respectively, as chromatographed bases and desyrel.
Please note: this information does not constitute health or medical advice.
Ursodiol ursofalk ; has been expanded to include all members of the departments of gastroenterology and hematology.
975-981 110 Feigelson J, Anagnostopoulos C, Poquet M, Pecau Y, Munck A, Navarro J. Liver cirrhosis in cystic fibrosis--therapeutic implications and long term follow up. Arch Dis Child 1993; 68: 653-657 Colombo C, Castellani MR, Balistreri WF, Seregni E, Assaisso ML, Giunta A. Scintigraphic documentation of an improvement in hepatobiliary excretory function after treatment with ursodeoxycholic acid in patients with cystic fibrosis and associated liver disease. Hepatology 1992; 15: 677-684 Colombo C, Crosignani A, Assaisso M, Battezzati PM, Podda M, Giunta A, Zimmer-Nechemias L, Setchell KD. Ursodeoxycholic acid therapy in cystic fibrosis-associated liver disease: a dose-response study. Hepatology 1992; 16: 924-930 Cotting J, Lentze MJ, Reichen J. Effects of ursodeoxycholic acid treatment on nutrition and liver function in patients with cystic fibrosis and longstanding cholestasis. Gut 1990; 31: 918-921 Colombo C, Battezzati PM, Podda M, Bettinardi N, Giunta A. Ursodeoxycholic acid for liver disease associated with cystic fibrosis: a double-blind multicenter trial. The Italian Group for the Study of Ursodeoxycholic Acid in Cystic Fibrosis. Hepatology 1996; 23: 1484-1490 Lindblad A, Glaumann H, Strandvik B. A two-year prospective study of the effect of ursodeoxycholic acid on urinary bile acid excretion and liver morphology in cystic fibrosis-associated liver disease. Hepatology 1998; 27: 166-174 van de Meeberg PC, Houwen RH, Sinaasappel M, Heijerman HG, Bijleveld CM, Vanberge-Henegouwen GP. Low-dose versus high-dose ursodeoxycholic acid in cystic fibrosis-related cholestatic liver disease. Results of a randomized study with 1-year follow-up. Scand J Gastroenterol 1997; 32: 369-373 Nathanson MH, Burgstahler AD, Masyuk A, Larusso NF. Stimulation of ATP secretion in the liver by therapeutic bile acids. Biochem J 2001; 358: 1-5 S- Editor Pan BR E- Editor Bai SH.
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Primary biliary cirrhosis PBC ; is characterized by a continuous T-lymphocyte mediated attack on small intralobular bile ducts, with their gradual destruction. Patients with PBC often exhibit concomitant autoimmune conditions, and autoimmune hemolytic anemia AIHA ; , that is idiopathic in 50% of cases, has rarely been associated to PBC. Ursodeoxycholic acid UDCA ; has been considered the main treatment to PBC patients through a decrease in the detergent effect of endogenous bile acids, concomitantly reducing the hemolytic process. We report the case of a female patient with AIHA complicating PBC, treated with short course prednisone and UDCA, with good response. Key Words: Primary biliary cirrhosis, Anemia, Hemolytic, Autoimmune, Ursodeoxycholic acid.
In May 2002, EpiCept announced it had initiated two multi-center phase II clinical trials in Canada and the U.S. following IND approval by Health Canada and the FDA. The trials aim to establish clinical dose, safety, and efficacy in the treatment of neuropathic pain. In March 2003, phase II trials in Canada were completed.
The insights of modern psychohistorians and psychiatrists to track the symptoms of post-traumatic stress syndrome. It is only by understanding that trauma experienced on a massive collective scale such as this could create the psychological and physiological conditions in which the emotional and intellectual characteristics we see as marking off So Tom as a unique Portuguese topical slave-society begin to make sense. It makes a kind of midrashic sense but it does not form logically-coherent narratives, since, as Robbins points out, "If no major elements of the story are suppressed, repressed, dissociated, or discarded in a reductionistic manner, coherence and clarity may be attained at the cost of psychic and objective reality." 21 According to Elias Lipiner, in his review of the events leading up to the mass forced conversion of Jews in Portugal in 1497, on the order of King Dom Joo these approximately two thousand young children "were seized and sent to settle the inhospitable island of So Tom, where they were educated in the Catholic religion. According to the chroniclers, many of these children were devoured by wild animals." 22 In his notes, Lipiner cites for these two assertions--the education of the Jewish children and their being devoured by wild animals--one Portuguese, Rui de Pina's Chronica d'elrey D. Joo II, and two Jewish sources, Immanuel Aboab's Nomologia o Discursos Legales Amsterdam 1629 ; and Samuel Usque's Consolao s tribulaes de Israel Ferrara 1553 ; .23 On the face of it, there are two different kinds of historical discourses here, one, the official Christian chronicler making an attempt to rationalize the abusive treatment of the Jewish children by claiming they were handled as such minor converts normally were in Portugal, i.e., fostered to families or monasteries for religious instruction and upbringing. However, there is no documentary evidence to back up such positive treatment of these child slaves sold to the Portuguese captains who were attempting to establish So Tom as a viable economic venture.24 On the other, the face less easy to pinpoint in a normal historical approach, there is a mythic account of the terrible loss to the Jewish community of so many children to the brutality and cruelty of kidnapping, isolation, and exploitation, the devouring by wild animals standing metonymically for other forms of death, such as disease, overwork, and beatings by task-masters. These midrashic sources--poetic, mythic, allegorical, etc.--focus on the most dramatic of images of what actually happened to these young victims. These dramatic images serve as triggers to emotional states by releasing suppressed memories, somatic tensions in the very muscles, as it were, of the bodies in question. These are chemical hormonal ; changes in the physiology of the persons involved and can be traced in the bizarre behaviours and attitudes they display, although, of course, we can neither measure them with scientific accuracy nor interpret private and confessional statements. They are also midrashic triggers that pull together disparate image-complexes, break open words and phrases locked into conventional iconographic models, and reconfigure new imagery by radical reading-in.25 What is dredged up and put together by these individRobbins, "Oedipus" p. 23. Elias Lipiner, Two Portuguese Exiles in Castile: Dom David Negro and Dom Isaac Abravanel Jerusalem: The Magnes Press, Hebrew University, 1970, p. 22. 23 Lipiner, Two Portuguese Exiles, p. 22, n. 26. 24 That they were slaves is proved by the testament of Alvaro de Caminha whicxh grants them manumission upon his death on 24 April 1499; see Joo Martins da Silva Marques, "Descobrimentos portuguses: Documentos para a sua historia", N. 331, 1499 Abril 24, in Liba and Simms, Jewish Child Slaves, pp. 212-218. 25 On "reading-in, " see David Weiss Halivni, Peshat and Derash: Plain and Applied Meaning in Rabbinical Exegesis New York and Oxford: Oxford University Press, 1991 ; , pp. 6-8.
Achieving continuous growth by advancing a transformation from a business structure centered on products for the Japanese market for apparel through expansion of overseas business and development of business in non-apparel, industrial-use materials. R&D is focused on driving the growth of business in industrial-use materials to develop as a new core field of operation. For greater earnings in established businesses: Expansion in global markets. Development of RoicaTM as a leading global spandex brand, with production in six countries. Full utilization of available resources to expand earnings. Concerted forward-looking execution of investment for expansion. Intensive development of high value-added products. Establishment of pricing structure to reflect added value. For expansion of new businesses: Expansion of SolotexTM polytrimethylene terephthalate PTT ; fiber business in new application fields.
All experiments were performed with the approval of the local animal ethics committee. The experimental protocol was divided into four parts I-IV ; , as illustrated in Table 1. Male Sprague-Dawley rats ALAB, Sollentuna, Sweden ; weighing 250-280 g were used for Parts I-III. In Part IV, a similar but not identical strain of male rats SD, also from ALAB ; was used, for example, michael urso.
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The ovaries from each rat treated with eCGhCG were removed at 0, 4, 10 or after hCG administration, trimmed of visible fat and the oviduct was weighed and homogenized using a tissue homogenizer with Teflon pestle Eberbach ; in 500 l cold PBS, pH 7.4, containing a mixture of protease inhibitors 2 mmol EDTA l-1 , 20 mmol N -ethylmaleimide l-1 , 1 mmol phenylsulphonylfluoride l-1 and 1 mmol dithiothreitol l-1 ; . The homogenates were heated for 10 min at 100 C and centrifuged for 30 min at 10 000 g at 4 The supernatants were purified using Sep-Pak C18 cartridges, lyophilized and reconstituted before being assayed. -Endorphin was quantified by radioimmunoassay as in previous studies Faletti et al ., 1999b; Lomniczi et al ., 2000 ; using a highly specific antiserum kindly provided by G. Chrousos National Institute of Child Health and Human Development, Bethesda, MD ; . The sensitivity of the assay was 20 pg per tube and the curve was linear up to 1000 pg -endorphin. The antibody crossreacted on an equimolar basis with rat -endorphin and its immediate precursor, -lipotropin. Thus, the activity measured in this assay represents the combined concentrations of -endorphin and -lipotropin, and is referred to as -endorphin-like immunoreactivity. Methionine-enkephalin, -endorphin and other opioid peptides did not crossreact 0.1% crossreactivity ; . Human -endorphin 127 fraction ; from Peninsula Laboratories San Carlos, CA ; was used for iodination by chloramine T method, because this fraction has two tyrosine residues. Rat -endorphin has only one tyrosine.
Thomas P. Laughren, M.D., Director, Division of Psychiatry Products. Letter to Gerald R. L. Limp, Regulatory Affairs Director, AstraZeneca Pharmaceuticals, LP. October 10, 2006. 9 Agency for Healthcare Research Quality AHRQ ; . Efficacy and Comparative Effectiveness of OffLabel Use of Atypical Antipsychotics. AHRQ Publication No. 07-EHC003-EF, January 2007. 10 Carlson FA, Jensen PS, Findling RS, Meyer RE, Calabrese J, DelBello MP, Emslie G, Flynn L, Goodwin F, Hellander M, Kowatch R, Kusumakar V, Laughren T, Leibenluft E, McCracken J, Nottelmann E, Pine D, Sachs G, Shaffer D, Simar R, Strober M, Weller EB, Wozniak J, MD, and Youngstrom EA. Methodological Issues and Controversies in Clinical Trials with Child and Adolescent Patients with Bipolar Disorder: Report of a Consensus Conference. J Child Adolescent Psychopharmacology, 2003; 13 1 ; : 13-27. 11 Cooper WO, Arbogast PG, Ding H, Hickson GB, Fuchs DC, Ray WA. Trends in Prescribing of Antipsychotic Medications for US Children, Ambulatory Pediatrics, 2006; 6: 7983.
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Ical health and functioning in the elderly. J Epidemiol 1986; 124: 372 Himmelfarb S, Murrell SA. Reliability and validity of five mental health scales in older persons. J Gerontol 1983; 38: 3339. Ying YW. Nonresponse on the Center for Epidemiological StudiesDepression scale in Chinese Americans. Int J Soc Psychiatry 1989; 35: 156 Callahan CM, Wolinsky FD. The effect of gender and race on the measurement properties of the CES-D in older adults. Med Care 1994; 32: 34156. Robins LN, Helzer JE, Croughan J, Ratcliff KS. National Institute of Mental Health Diagnostic Interview Schedule: its history, characteristics, and validity. Arch Gen Psychiatry 1981; 38: 3819. Cohen HW, Madhavan S, Alderman MH. History of treatment for depression: risk factor for myocardial infarction in hypertensive patients. Psychosom Med 2001; 63: 2039. Statistical Package for the Social Sciences, version 10.0.5R. Chicago: SPSS Inc; 1999. Gerstmann BB, Jolson HM, Bauer M, Cho P, Livingston JM, Platt R. The incidence of depression in new users of beta-blockers and selected antihypertensives. J Clin Epidemiol 1996; 49: 809 Carney RM, Rich MW, teVelde A, Saini J, Clark K, Freedland KE. Prevalence of major depressive disorder in patients receiving betablocker therapy versus other medications. J Med 1987; 83: 223 Ried LD, Johnson RE, McFarland BH, Brody KK. Antihypertensive drug use and the risk of depression among older hypertensives in an HMO. J Pharmacoepidemiol 2000; 8: 128. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, Jones DW, Materson BJ, Oparil S, Wright JT Jr, Roccella EJ, Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure, National Heart, Lung, and Blood Institute, National High Blood Pressure Education Program Coordinating Committee. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. JAMA 2003; 289: 2560 Jorge RE, Robinson RG, Arndt S, Starkstein S. Mortality and poststroke depression: a placebo-controlled trial of antidepressants. J Psychiatry 2003; 160: 18239. Schulz R, Beach SR, Ives DG, Martire LM, Ariyo AA, Kop WJ. Association between depression and mortality in older adults: the Cardiovascular Health Study. Arch Intern Med 2000; 160: 1761 Wulsin LR, Vaillant GE, Wells VE. A systematic review of the mortality of depression. Psychosom Med 1999; 61: 6 Lyness JM, Caine ED, King DA, Conwell Y, Cox C, Duberstein PR. Cerebrovascular risk factors and depression in older primary care patients: testing a vascular brain disease model of depression. J Geriatr Psychiatry 1999; 7: 252 Mast BT, Neufeld S, MacNeill SE, Lichtenberg PA. Longitudinal support for the relationship between vascular risk factors and late-life depressive symptoms. J Geriatr Psychiatry 2004; 12: 93101. Alexopoulos GS, Meyers BS, Young RC, Campbell S, Silbersweig D, Charlson M. `Vascular depression' hypothesis. Arch Gen Psychiatry 1997; 54: 91522. Hollister LE, Trevino ES. Calcium channel blockers in psychiatric disorders: a review of the literature. Can J Psychiatry 1999; 44: 658 Hjalmarson AC. Use of beta blockers in postinfarct prophylaxis: aspects on quality of life. Heart J 1987; 114: 24550. Davis BR, Furberg CD, Williams CB. Survival analysis of adverse effects data in the Beta-Blocker Heart Attack Trial. Clin Pharmacol Ther 1987; 41: 6115. Wassertheil-Smoller S, Applegate WB, Berge K, Chang CJ, Davis BR, Grimm R, Kostis J, Pressel S, Schron E. Change in depression as a precursor of cardiovascular events. Arch Intern Med 1996; 156: 553 Gowans SE, deHueck A, Abbey SE. Measuring exercise-induced mood changes in fibromyalgia: a comparison of several measures. Arthritis Rheum 2002; 47: 6039.
Enterolith formation associated with Crohn's disease is a very uncommon clinical entity. Plain film radiography and computed tomography play a central role in establishing the diagnosis of this rare condition and assist in planning surgical intervention.
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Pression Fig. 4A and B ; . Expression of spliced TNF- mRNA, by contrast, was strongly inhibited at 24 h and beyond Fig. 4C ; . In the presence of 2-AP levels of precursor transcripts had increased by 7.6-fold at 24 h, relative to that of the untreated control Fig. 4E ; , while levels of mRNA had decreased by 7.7-fold Fig. 4F ; . These representative kinetic data demonstrate a significant decline in the flow of precursors into TNFmRNA. They show that the accumulation of precursor transcripts occurs promptly and in the same cells in which the accumulation of TNF- mRNA is inhibited. In agreement with an earlier report 32 ; , expression of mRNA from a cotransfected CAT gene was not noticeably affected by 2-AP Fig. 4D and G ; , showing that efficiency of transfection was constant. The 2-AP-sensitive mechanism that supports splicing of TNFprecursor RNA in PBMC thus is also present in BHK-21 cells. 2-AP elicits accumulation of unstable, functional TNFprecursor transcripts. The accumulation of unspliced TNFprecursor transcripts occurred when 2-AP was present from the outset of induction Fig. 2A ; . In the experiment shown in Fig. 5, 2-AP was introduced later, at 3 h, a time at which precursor levels were still rising. Within 1 h, an extensive increase in the level of precursor transcripts was observed. Their level became maximal within 3 h before declining gradually, with large amounts of precursors still present 4 h later Fig. 5 ; . However, this increase in the level of precursor transcripts was not matched by a decrease in the level of TNF- mRNA. Indeed, when added after 3 h of induction, 2-AP failed to affect the subsequent expression of mRNA perceptibly, including the rise between 4 and 6 h, showing that splicing was no longer blocked by that time and that the presence of 2-AP did not affect TNF- mRNA stability. Because mRNA could still be generated, the 2-AP-induced rise in the precursor transcript level apparently involves functional TNF- RNA molecules.
SALES Two key factors affected reported Group sales during the January-June period. Acquisition of Cibacen, Cibadrex, and Cyklokapron for cardiovascular disorders ; generated about SEK 275 million in sales, while sale of the parallel trading operation reduced sales as per IFRS 5 ; by SEK 123 million. The changed product structure had positive effects on profitability. Among other products in the Pharma operation, these demonstrated more than 20% sales growth: Relifex inflammation ; , Ursofalk liver diseases ; , Lederspan osteoarthritis and rheumatoid arthritis ; , Zanidip high blood pressure ; , Colazid ulcerative colitis ; Period sales, in SEK million, for the two remaining operations: Jan-June 2005 Pharma Medical Device 651 61 Jan-June 2004 309 54 Index.
Copenhagen, Denmark ; and a confocal laser-scanning microscope LSM510, Zeiss, Gttingen, Germany ; . Statistics Data are expressed as mean SE. The Wilcoxon-matched pairs and Mann-Whitney tests were used for comparison of data within and between groups, respectively. P-values 0.05 were considered statistically significant. RESULTS Surgical reduction of the blood flow to the anterior left ventricular wall lead to slight discoloration of the affected myocardium Fig. 1A ; and a decrease of the oxygen tension in the affected region from 46 4 to mmHg after 15 min Fig. 1B ; . To see whether the reduced oxygen tension resulted in stimulation of HIF-1 regulated gene transcription, we quantified VEGF mRNA. After 2.2 0.2 h, the expression of VEGF mRNA was increased 1.8-fold in the hypoxic region compared with normoxic myocardium P 0.001, Fig. 1C ; . The content of BNP mRNA in the hypoxic myocardium was increased 3.5-fold compared with that in normoxic myocardium P 0.005, Fig. 2A ; . A positive correlation was found between the increase in VEGF and BNP mRNA contents in the hypoxic myocardium r 0.66, P 0.05, data not shown ; . The porcine myocardium contains significant amounts of immature BNP pre-mRNA 37 ; . Quantification with a BNP pre-mRNA specific real-time PCR assay revealed that the BNP premRNA content was 4.8-fold higher in the hypoxic compared with the normoxic myocardium P 0.005, Fig. 2B ; . The VEGF mRNA, BNP mRNA, and BNP pre-mRNA contents were similar in the normoxic anterior and inferior left ventricular walls in control pigs Figs. 1C, 2A, B ; . To assess whether the increased BNP gene expression in hypoxic ventricular myocardium was accompanied by increased BNP peptide production, we analyzed BNP and proBNP peptides in myocardial tissue with radioimmunoassays and immunohistochemistry. However, neither hypoxic nor normoxic left ventricular myocardium contained detectable proBNP concentrations by RIA Fig. 3A ; or on immunohistochemistry Fig. 3B ; . In contrast, left atrial tissue contained both BNP and proBNP peptides, with a markedly lower BNP than proBNP concentration Fig. 3C ; . Confocal laser-scanning microscopy of immunostained atrial sections showed a granularlike appearance of proBNP extending along the contractile apparatus in the myocytes Fig. 3D ; . Gel chromatography of medium from freshly harvested atrial cells kept revealed two forms of proBNP-derived peptides, i.e., the intact precursor and a smaller N-terminal fragment Fig. 3E ; , and a small amount of BNP. The plasma proBNP concentrations in hypoxic pigs increased 2 h after induction of myocardial hypoxia P 0.028, Fig. 4A ; . In control pigs without surgical reduction of the blood flow, the proBNP plasma concentration was not significantly different from baseline values 9510.2%, P 0.62 ; . The absence of BNP and proBNP peptides in the ventricular myocardium may reflect rapid release of newly synthesized peptide from the myocytes. To examine this possibility, we kept freshly harvested ventricular cells for 3 h in serum-free culture medium. Although the cells did not contain detectable amounts of BNP or proBNP peptides before or after incubation, we found proBNP accumulation in the culture medium P 0.0001, Fig. 4B ; . The oxygen tension and pH did not change in the culture medium during the experiments data not shown.
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