Detected. The following material weaknesses have been identified and included in management's assessment. As of December 31, 2004 management concluded that the Company did not maintain effective internal control over i ; sales and sales returns and ii ; the financial statement close process. These material weaknesses were considered in determining the nature, timing, and extent of audit tests applied in our audit of the 2004 financial statements, and this report does not affect our report dated February 14, 2005 on those financial statements. In our opinion, management's assessment that the Company did not maintain effective internal control over financial reporting as of December 31, 2004, is fairly stated, in all material respects, based on criteria established in Internal Control--Integrated Framework issued by the Committee of Sponsoring Organizations of the Treadway Commission COSO ; . Also, in our opinion, because of the effect of the material weakness described above on the achievement of the objectives of the control criteria, the Company has not maintained effective internal control over financial reporting as of December 31, 2004, based on criteria established in Internal Control--Integrated Framework issued by the Committee of Sponsoring Organizations of the Treadway Commission COSO ; . We have also audited, in accordance with the standards of the Public Company Accounting Oversight Board United States ; , the consolidated balance sheets of Columbia Laboratories, Inc. as of December 31, 2004 and 2003 and the related consolidated statements of operations, comprehensive operations, stockholders' equity deficiency ; and cash flows for each of the three years in the period ended December 31, 2004 of Columbia Laboratories, Inc. and our report dated February 14, 2005 expressed an unqualified opinion on these financial statements. GOLDSTEIN GOLUB KESSLER LLP New York, New York April 26, 2005 Item 15. Exhibits and Financial Statement Schedules a ; 1 ; 2 ; Financial Statements and Financial Statement Schedules Indexes to financial statements and financial statement schedules appear on F-1 and F-26, respectively. b ; Exhibits 3.1 3.2 4.1 --Restated Certificate of Incorporation of the Company, as amended1 Amended and Restated By-laws of Company10 Certificate of Designations, Preferences and Rights of Series C Convertible Preferred Stock of the Company, dated as of January 7, 199910 Securities Purchase Agreement, dated as of January 7, 1999, between the Company and each of the purchasers named on the signature pages thereto10 Securities Purchase Agreement, dated as of January 19, 1999, among the Company, David M. Knott and Knott Partners, L.P.10 Securities Purchase Agreement, dated as of February 1, 1999, between the Company and Windsor Partners, L.P.10 Registration Rights Agreement, dated as of January 7, 1999, between the Company and each of the purchasers named on the signature pages thereto10 Form of Warrant to Purchase Common Stock10 Warrant to Purchase Common Stock granted to James J. Apostolakis on September 23, 1999 Employment Agreement dated as of January 1, 1996, between the Company and Norman M. Meier6 * Employment Agreement dated as of January 1, 1996, between the Company and William J. Bologna6 * 1988 Stock Option Plan, as amended, of the Company4 1996 Long-term Performance Plan, as amended, of the Company7 License and Supply Agreement between Warner-Lambert Company and the Company dated December 5, 19913 Asset Purchase, License and Option Agreement, dated November 22, 19891 Employment Agreement dated as of April 15, 1997, between the Company and Nicholas A. Buoniconti8 * License and Supply Agreement for Crinone between Columbia Laboratories, Inc. Bermuda ; Ltd. and American Home Products dated as of May 21, 19955.
Fig. 10. Effect of C48 80 on degranulation of mast cells under histological examination. A: high-magnification photomicrograph of a portion of the cranial part CM ; of ME level i ii in Fig. 9 ; in a C48 80-treated animal. Black arrow, intact mast cell; open arrow, degranulated mast cell; black arrowheads, capillaries of the hypophysial portal system. B: populations of activated and inactivated mast cells in and around the median eminence in dogs treated with n 4 ; or without n 4 ; C48 80. MM, medial part of ME level iii iv in Fig. 9 VM, ventral part of ME level v in Fig. 9 ; . Values are means SE. * P 0.05 vs. corresponding animals without C48 80. AJP-Regul Integr Comp Physiol VOL, because ultram.
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Virtual Reality Virtual Reality and Mastering of Complex Systems Computer graphics, systems of geographical information and virtual reality Foundations of the computer graphics Research on treatments based on virtual reality Doctoral Program on Basic Processes and Intervention in Clinical and Health Psychology. Representation of 3D objects in animation and virtual reality Image Synthesis and Virtual Reality Doctoral Program on Advanced Computing Systems Doctoral Program on Software.
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EXECUTIVE SUMMARY METHODOLOGY 1.0 AD OVERVIEW 1.1 Definition of AD 1.1.1 Symptoms 1.1.2 Diagnosis 1.2 Segmentation of AD 1.3 Prevalence of AD 1.4 Unmet Needs in AD 1.5 Market Analyses Assumptions 1.5.1 Generic Competition 1.5.2 UK Forecasts 1.5.3 Mild to Moderate Market Assumptions 1.5.4 Moderate to Severe Market Assumptions 1.6 Market Analysis 1.6.1 US Market Forecast 1.6.2 European Market Forecast 1.6.3 Japanese Market Forecast 1.7 Competitive Analysis 1.8 Drugs That Address Associated Conditions 1.9 AD Research and Development 1.9.1 ACh Modulators 1.9.2 Neuroprotective and Neurotrophic Drugs 1.9.3 Beta-Amyloid Modulators.
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Foreword Abstract Acronym List I. Introduction 1 Jeongim Park 1. Research Background and Rationale1 2. Review of Recent Research in Korea 4 3. Scope and Objectives 11 PART I. Prioritization of Pharmaceuticals of Concern in Korean Environment II. Are the Existing Ranking Systems for Chemicals Applicable to Pharmaceuticals, too? 17 MyungHyun Kim, Jeongim Park 1. Introduction17 2. Overview of Prioritization Methodologies for Chemicals18 A. CHEMS1 21 B. EURAM27 3. Conclusion31.
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GSK's ability in 2006 to deliver continued pharmaceutical turnover growth was primarily due to an exceptionally broad product portfolio of high-value growth products coupled with sales and marketing excellence. These growth products include Seretide Advair, the Avandia product group, Vaccines, Lamictal, Valtrex, Coreg, Requip, Avodart and Boniva.
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Inconclusive A series of study results are inconclusive when the evidence of different studies do not conflict with each other, but nonetheless lack the strength to be able to reach a definite conclusion. Incremental cost per QALY The additional cost incurred for each additional QALY. See also `incremental cost-effectiveness ratio'. Incremental cost-effectiveness ratio ICER ; A ratio obtained by dividing the incremental costs cost difference ; by the incremental benefits outcome differences ; for two interventions. This depicts the extra cost per unit of outcome. A decision will be made as to whether the additional cost per unit of outcome is worth paying for based on the decision-maker's willingness to pay. Independent predictor A variable whose value predicts the occurrence of an event independent of the values of other variables. Infarction An ischaemic lesion. Cerebral infarctions can result in stroke, and myocardial infarctions can result in a heart attack. See also `myocardial infarction'. Informed dissent The situation whereby a patient elects to abstain from receiving the optimal therapeutic intervention in the knowledge that this could cause them harm. Inotropic Drugs that can stimulate the contraction of the heart. Intention-to-treat analysis ITT analysis ; An analysis of the results of a clinical study in which the data are analysed for all study participants as if they had remained in the group to which they were randomised, regardless of whether or not they remained in the study until the end, crossed over to another treatment or received an alternative intervention. Intermittent atrial fibrillation AF that is not sustained, but interrupted by periods of sinus rhythm. Intermittent AF is normally considered to apply to more patients than paroxysmal AF, since the periods of sinus rhythm in the former may be very brief and otherwise insignificant. International normalised ratio INR ; A measure of the clotting ability of blood, usually following use of anticoagulant drugs. It is calculated as the ratio of the length of time it takes blood to clot over the time it would take the blood of a normal subject to clot. Intracardiac Occurring within the chambers of the heart. Intracranial haemorrhage A bleeding event within the brain, which may result in a haemorrhagic stroke. Intubation Being intubated with a transoesophageal breathing tube connected to a mechanical ventilator. Ischaemic heart disease Heart disease characterised by a reduced supply of blood to the heart. See also `coronary artery disease'. Ischaemic stroke Stroke caused by cerebral infarction. Lacunar infarction Stroke secondary to blockage of the small vessels especially at the border of zones supplied by different arteries. Left atrial appendage velocity A measurement of the blood flow within the left atrial appendage, usually on TEE, because valtrrx cost.
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Ja 26 ; En 04807490.0 22 ; 15.12.2004 AT BE BG 2004 019133 15.12.2004 WO 2005 056092 2005 JP 2003416308 24.12.2003 JP 2003426457 BEFEUCHTUNGSVORRICHTUNG UND SAUERSTOFFKONZENTRATIONSSYSTEM HUMIDIFYING DEVICE AND OXYGEN CONCENTRATING SYSTEM DISPOSITIF D'HUMIDIFICATION ET SYSTEME DE CONCENTRATION D'OXYGENE Teijin Pharma Limited, 1-1, Uchisaiwaicho 2-chome, Chiyoda-ku, Tokyo 100-0011, JP TAKEDA, Toshihiro, c o TEIJIN PHARMA LIMITED, Tokyo 100-0011, JP NISHIHIRA, Morihiko, 2720144, JP TANIHARA, Nozomu, c o Ube Chemical Factory, Ube-shi, Yamaguchi 755-8633, JP HOFFMANN EITLE, Patent- und Rechtsanwalte Arabellastrasse 4, 81925 Munchen, DE, because prescription drugs.
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The results of these mutagenicity tests in vitro and in vivo suggest that valaciclovir and aciclovir are unlikely to pose a genetic threat to man at therapeutic dose levels. Carcinogenic Potential The data presented below include references to the steady-state aciclovir AUC observed in humans treated with 1 gram Valt5ex given orally three times a day to treat herpes zoster HZV ; or with 2 gram Avltrex given orally four times a day to treat cytomegalovirus CMV ; . Plasma drug concentrations in animal studies are expressed as multiples of human exposure to aciclovir. Valaciclovir was noncarcinogenic in lifetime carcinogenicity bioassays at oral doses of up to 120 mg kg day for mice and 100 mg kg day for rats. There was no significant difference in the incidence of tumours between treated and control animals, nor did valaciclovir shorten the latency of tumours. Plasma concentrations AUC ; of aciclovir were equivalent to 1.1 HZV ; and 0.1 times CMV ; human levels in the mouse bioassay and 1.3 HZV ; and 0.1 CMV ; times human concentrations in the rat bioassay. Effects on Fertility Valaciclovir did not impair fertility or reproduction in rats at 200mg kg per day, corresponding to plasma levels 2.8 HZV ; and 0.3 CMV ; times human plasma concentrations AUC.
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Extension Activities Science: Investigate genetic factors that influence risk of addiction. Science: Research why pain sufferers who use opiate analgesics are at a low risk for addiction. Language Arts: Interview a physician or mental health care worker involved in treating persons with substance abuse problems. History: Research the history of drug treatment.
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Match was found for wet and air-dry specimens with curves for partly segregated interstratification at S 0.4 and the percentage content o f 10.1-]k c o m p 0.7 and 0.6, respectively. For an almost dehydrated specimen a good match was established with a partially ordered curve D 0.5 ; for 0.2 o f 10.1-, A, layers. When a rigorous, quantitative approach is desirable, an accurate modeling o f diffraction m a x should be attempted. This modeling involves dealing with several problems, including the best form o f LP, the n u m ber o f layers in the interstratified assemblage, the correct atomic scattering factors, and the contribution o f interlamellar material to SFL.
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